Introduction

MicroRNAs (miRNAs) are a class of small RNAs that post-transcriptionally regulate gene expression in animals and plants. The recent rapid advancement in miRNA biology, including high-throughput sequencing of small RNA libraries, inspired the development of a bioinformatics software, miRAuto, which predicts putative miRNAs in model plant genomes computationally. Furthermore, miRAuto enables users to identify miRNAs in non-model plant species whose genomes have yet to be fully sequenced. miRAuto analyzes the expression of the 5'-end position of mapped small RNAs in reference sequences to prevent the possibility of mRNA fragments being included as candidate miRNAs. We validated the utility of miRAuto on a small RNA dataset, and the results were compared to other publicly available miRNA prediction programs. In conclusion, miRAuto is a fully automated user-friendly tool for predicting miRNAs from small RNA sequencing data in both model and non-model plant species. miRAuto is available at http://nature.snu.ac.kr/software/miRAuto.htm.

Publications

  1. MiRAuto: an automated user-friendly microRNA prediction tool utilizing plant small RNA sequencing data.
    Cite this
    Lee J, Kim DI, Park JH, Choi IY, Shin C, 2013-04-01 - Molecules and cells

Credits

  1. Jeongsoo Lee
    Developer

    National Instrumentation Center for Environmental Management, College of Agriculture and Life Sciences

  2. Dong-In Kim
    Developer

  3. June Hyun Park
    Developer

  4. Ik-Young Choi
    Developer

  5. Chanseok Shin
    Investigator

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Summary
AccessionBT001649
Tool TypeApplication
Category
PlatformsLinux/Unix
TechnologiesPerl
User InterfaceTerminal Command Line
Download Count0
Submitted ByChanseok Shin