Introduction

A combination of bisulfite treatment of DNA and high-throughput sequencing (BS-Seq) can capture a snapshot of a cell's epigenomic state by revealing its genome-wide cytosine methylation at single base resolution. Bismark is a flexible tool for the time-efficient analysis of BS-Seq data which performs both read mapping and methylation calling in a single convenient step. Its output discriminates between cytosines in CpG, CHG and CHH context and enables bench scientists to visualize and interpret their methylation data soon after the sequencing run is completed.Bismark is released under the GNU GPLv3+ licence. The source code is freely available from www.bioinformatics.bbsrc.ac.uk/projects/bismark/.

Publications

  1. Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications.
    Cite this
    Krueger F, Andrews SR, 2011-06-01 - Bioinformatics (Oxford, England)

Credits

  1. Felix Krueger
    Developer

    Bioinformatics Group, The Babraham Institute

  2. Simon R Andrews
    Investigator

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Summary
AccessionBT001685
Tool TypeApplication
Category
PlatformsLinux/Unix
TechnologiesPerl
User InterfaceTerminal Command Line
Download Count0
Submitted BySimon R Andrews