Introduction

Modern population genetics studies typically involve genome-wide genotyping of individuals from a diverse network of ancestries. An important problem is how to formulate and estimate probabilistic models of observed genotypes that account for complex population structure. The most prominent work on this problem has focused on estimating a model of admixture proportions of ancestral populations for each individual. Here, we instead focus on modeling variation of the genotypes without requiring a higher-level admixture interpretation.We formulate two general probabilistic models, and we propose computationally efficient algorithms to estimate them. First, we show how principal component analysis can be utilized to estimate a general model that includes the well-known Pritchard-Stephens-Donnelly admixture model as a special case. Noting some drawbacks of this approach, we introduce a new 'logistic factor analysis' framework that seeks to directly model the logit transformation of probabilities underlying observed genotypes in terms of latent variables that capture population structure. We demonstrate these advances on data from the Human Genome Diversity Panel and 1000 Genomes Project, where we are able to identify SNPs that are highly differentiated with respect to structure while making minimal modeling assumptions.A Bioconductor R package called lfa is available at http://www.bioconductor.org/packages/release/bioc/html/lfa.htmljstorey@princeton.eduSupplementary data are available at Bioinformatics online.

Publications

  1. Probabilistic models of genetic variation in structured populations applied to global human studies.
    Cite this
    Hao W, Song M, Storey JD, 2016-03-01 - Bioinformatics (Oxford, England)

Credits

  1. Wei Hao
    Developer

  2. Minsun Song
    Developer

  3. John D Storey
    Investigator

    Lewis-Sigler Institute for Integrative Genomics and Center for Statistics and Machine Learning, Princeton University, United States of America

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Summary
AccessionBT001947
Tool TypeApplication
Category
PlatformsLinux/Unix
TechnologiesR
User InterfaceTerminal Command Line
Download Count0
Country/RegionUnited States of America
Submitted ByJohn D Storey