Introduction

: The public availability of high throughput molecular data provides new opportunities for researchers to advance discovery, replication and validation efforts. One common challenge in leveraging such data is the diversity of measurement approaches and platforms and a lack of utilities enabling cross-platform comparisons among data sources for analysis. We present a method to map DNA methylation data from bisulfite sequencing approaches to CpG sites measured with the widely used Illumina methylation bead-array platforms. Correlations and median absolute deviations support the validity of using bisulfite sequencing data in combination with Illumina bead-array methylation data.https://github.com/Christensen-Lab-Dartmouth/methyLiftover includes source, documentation and data references.brock.c.christensen@dartmouth.eduSupplementary data are available at Bioinformatics online.

Publications

  1. methyLiftover: cross-platform DNA methylation data integration.
    Cite this
    Titus AJ, Houseman EA, Johnson KC, Christensen BC, 2016-08-01 - Bioinformatics (Oxford, England)

Credits

  1. Alexander J Titus
    Developer

    Department of Epidemiology, Geisel School of Medicine at Dartmouth, United States of America

  2. E Andrés Houseman
    Developer

    Department of Biostatistics, Oregon State University College of Public Health and Human Sciences, United States of America

  3. Kevin C Johnson
    Developer

    Department of Epidemiology, Geisel School of Medicine at Dartmouth, United States of America

  4. Brock C Christensen
    Investigator

    Department of Epidemiology, Geisel School of Medicine at Dartmouth, United States of America

Community Ratings

UsabilityEfficiencyReliabilityRated By
0 user
Sign in to rate
Summary
AccessionBT002225
Tool TypeApplication
Category
PlatformsLinux/Unix
TechnologiesR
User InterfaceTerminal Command Line
Download Count0
Country/RegionUnited States of America
Submitted ByBrock C Christensen