Introduction

Hydrogen/deuterium exchange mass spectrometry (HDX-MS) is an established method for the interrogation of protein conformation and dynamics. While the data analysis challenge of HDX-MS has been addressed by a number of software packages, new computational tools are needed to keep pace with the improved methods and throughput of this technique. To address these needs, we report an integrated desktop program titled HDX Workbench, which facilitates automation, management, visualization, and statistical cross-comparison of large HDX data sets. Using the software, validated data analysis can be achieved at the rate of generation. The application is available at the project home page http://hdx.florida.scripps.edu .

Publications

  1. HDX workbench: software for the analysis of H/D exchange MS data.
    Cite this
    Pascal BD, Willis S, Lauer JL, Landgraf RR, West GM, Marciano D, Novick S, Goswami D, Chalmers MJ, Griffin PR, 2012-09-01 - Journal of the American Society for Mass Spectrometry

Credits

  1. Bruce D Pascal
    Developer

    Department of Molecular Therapeutics, The Scripps Research Institute-Scripps Florida, United States of America

  2. Scooter Willis
    Developer

  3. Janelle L Lauer
    Developer

  4. Rachelle R Landgraf
    Developer

  5. Graham M West
    Developer

  6. David Marciano
    Developer

  7. Scott Novick
    Developer

  8. Devrishi Goswami
    Developer

  9. Michael J Chalmers
    Developer

  10. Patrick R Griffin
    Investigator

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Summary
AccessionBT002316
Tool TypeApplication
Category
PlatformsWindows
Technologies
User InterfaceTerminal Command Line
Download Count0
Submitted ByPatrick R Griffin