Introduction

Computational diagnosis of amino acid variants in the human exome is the first step in assessing the disruptive impacts of non-synonymous single nucleotide variants (nsSNVs) on human health and disease. The Molecular Evolutionary Genetics Analysis software with mutational diagnosis (MEGA-MD) is a suite of tools developed to forecast the deleteriousness of nsSNVs using multiple methods and to explore nsSNVs in the context of the variability permitted in the long-term evolution of the affected position. In its graphical interface for use on desktops, it enables interactive computational diagnosis and evolutionary exploration of nsSNVs. As a web service, MEGA-MD is suitable for diagnosing variants on an exome scale. The MEGA-MD suite intends to serve the needs for conducting low- and high-throughput analysis of nsSNVs in diverse applications.

Publications

  1. MEGA-MD: molecular evolutionary genetics analysis software with mutational diagnosis of amino acid variation.
    Cite this
    Stecher G, Liu L, Sanderford M, Peterson D, Tamura K, Kumar S, 2014-05-01 - Bioinformatics (Oxford, England)

Credits

  1. Glen Stecher
    Developer

    Center for Evolutionary Medicine and Informatics, Biodesign Institute, Saudi Arabia

  2. Li Liu
    Developer

  3. Maxwell Sanderford
    Developer

  4. Daniel Peterson
    Developer

  5. Koichiro Tamura
    Developer

  6. Sudhir Kumar
    Investigator

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Summary
AccessionBT002781
Tool TypeApplication
Category
PlatformsWindows
Technologies
User InterfaceTerminal Command Line
Download Count0
Submitted BySudhir Kumar