Introduction

The identification of protein post-translational modifications (PTMs) is an increasingly important component of proteomics and biomarker discovery, but very few tools exist for performing fast and easy characterization of global PTM changes and differential comparison of PTMs across groups of data obtained from liquid chromatography-tandem mass spectrometry experiments. STRAP PTM (Software Tool for Rapid Annotation of Proteins: Post-Translational Modification edition) is a program that was developed to facilitate the characterization of PTMs using spectral counting and a novel scoring algorithm to accelerate the identification of differential PTMs from complex data sets. The software facilitates multi-sample comparison by collating, scoring, and ranking PTMs and by summarizing data visually. The freely available software (beta release) installs on a PC and processes data in protXML format obtained from files parsed through the Trans-Proteomic Pipeline. The easy-to-use interface allows examination of results at protein, peptide, and PTM levels, and the overall design offers tremendous flexibility that provides proteomics insight beyond simple assignment and counting.

Publications

  1. STRAP PTM: Software Tool for Rapid Annotation and Differential Comparison of Protein Post-Translational Modifications.
    Cite this
    Spencer JL, Bhatia VN, Whelan SA, Costello CE, McComb ME, 2013-12-01 - Current protocols in bioinformatics

Credits

  1. Jean L Spencer
    Developer

    Cardiovascular Proteomics Center, Boston University School of Medicine, United States of America

  2. Vivek N Bhatia
    Developer

    Cardiovascular Proteomics Center, Boston University School of Medicine, United States of America

  3. Stephen A Whelan
    Developer

    Cardiovascular Proteomics Center, Boston University School of Medicine, United States of America

  4. Catherine E Costello
    Developer

    Cardiovascular Proteomics Center, Boston University School of Medicine, United States of America

  5. Mark E McComb
    Investigator

    Cardiovascular Proteomics Center, Boston University School of Medicine, United States of America

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Summary
AccessionBT005435
Tool TypeApplication
Category
PlatformsWindows
Technologies
User InterfaceTerminal Command Line
Download Count0
Country/RegionUnited States of America
Submitted ByMark E McComb