Introduction

The relative ease and low cost of current generation sequencing technologies has led to a dramatic increase in the number of sequenced genomes for species across the tree of life. This increasing volume of data requires tools that can quickly compare multiple whole-genome sequences, millions of base pairs in length, to aid in the study of populations, pan-genomes, and genome evolution.We present a new multiple alignment tool for whole genomes named Mugsy. Mugsy is computationally efficient and can align 31 Streptococcus pneumoniae genomes in less than 2 hours producing alignments that compare favorably to other tools. Mugsy is also the fastest program evaluated for the multiple alignment of assembled human chromosome sequences from four individuals. Mugsy does not require a reference sequence, can align mixtures of assembled draft and completed genome data, and is robust in identifying a rich complement of genetic variation including duplications, rearrangements, and large-scale gain and loss of sequence.Mugsy is free, open-source software available from http://mugsy.sf.net.

Publications

  1. Mugsy: fast multiple alignment of closely related whole genomes.
    Cite this
    Angiuoli SV, Salzberg SL, 2011-02-01 - Bioinformatics (Oxford, England)

Credits

  1. Samuel V Angiuoli
    Developer

    Center for Bioinformatics and Computational Biology, University of Maryland, United States of America

  2. Steven L Salzberg
    Investigator

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Summary
AccessionBT006320
Tool TypeApplication
Category
PlatformsLinux/Unix
Technologies
User InterfaceTerminal Command Line
Download Count0
Submitted BySteven L Salzberg