Introduction

Most of the published quantitative models in biology are lost for the community because they are either not made available or they are insufficiently characterized to allow them to be reused. The lack of a standard description format, lack of stringent reviewing and authors' carelessness are the main causes for incomplete model descriptions. With today's increased interest in detailed biochemical models, it is necessary to define a minimum quality standard for the encoding of those models. We propose a set of rules for curating quantitative models of biological systems. These rules define procedures for encoding and annotating models represented in machine-readable form. We believe their application will enable users to (i) have confidence that curated models are an accurate reflection of their associated reference descriptions, (ii) search collections of curated models with precision, (iii) quickly identify the biological phenomena that a given curated model or model constituent represents and (iv) facilitate model reuse and composition into large subcellular models.

Publications

  1. Minimum information requested in the annotation of biochemical models (MIRIAM).
    Cite this
    Le Novère N, Finney A, Hucka M, Bhalla US, Campagne F, Collado-Vides J, Crampin EJ, Halstead M, Klipp E, Mendes P, Nielsen P, Sauro H, Shapiro B, Snoep JL, Spence HD, Wanner BL, 2005-12-01 - Nature biotechnology

Credits

  1. Nicolas Le Novère
    Developer

  2. Andrew Finney
    Developer

  3. Michael Hucka
    Developer

  4. Upinder S Bhalla
    Developer

  5. Fabien Campagne
    Developer

  6. Julio Collado-Vides
    Developer

  7. Edmund J Crampin
    Developer

  8. Matt Halstead
    Developer

  9. Edda Klipp
    Developer

  10. Pedro Mendes
    Developer

  11. Poul Nielsen
    Developer

  12. Herbert Sauro
    Developer

  13. Bruce Shapiro
    Developer

  14. Jacky L Snoep
    Developer

  15. Hugh D Spence
    Developer

  16. Barry L Wanner
    Investigator

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Summary
AccessionBT006335
Tool TypeApplication
Category
PlatformsLinux/Unix
TechnologiesC++
User InterfaceTerminal Command Line
Download Count0
Submitted ByBarry L Wanner