Introduction

Antibody amino-acid sequences can be numbered to identify equivalent positions. Such annotations are valuable for antibody sequence comparison, protein structure modelling and engineering. Multiple different numbering schemes exist, they vary in the nomenclature they use to annotate residue positions, their definitions of position equivalence and their popularity within different scientific disciplines. However, currently no publicly available software exists that can apply all the most widely used schemes or for which an executable can be obtained under an open license.ANARCI is a tool to classify and number antibody and T-cell receptor amino-acid variable domain sequences. It can annotate sequences with the five most popular numbering schemes: Kabat, Chothia, Enhanced Chothia, IMGT and AHo.ANARCI is available for download under GPLv3 license at opig.stats.ox.ac.uk/webapps/anarci. A web-interface to the program is available at the same address.deane@stats.ox.ac.uk.

Publications

  1. ANARCI: antigen receptor numbering and receptor classification.
    Cite this
    Dunbar J, Deane CM, 2016-01-01 - Bioinformatics (Oxford, England)

Credits

  1. James Dunbar
    Developer

    Department of Statistics, Oxford University

  2. Charlotte M Deane
    Investigator

    Department of Statistics, Oxford University

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Summary
AccessionBT006336
Tool TypeApplication
Category
PlatformsLinux/Unix
Technologies
User InterfaceTerminal Command Line
Download Count0
Submitted ByCharlotte M Deane