Introduction

Shared-usage high throughput screening (HTS) facilities are becoming more common in academe as large-scale small molecule and genome-scale RNAi screening strategies are adopted for basic research purposes. These shared facilities require a unique informatics infrastructure that must not only provide access to and analysis of screening data, but must also manage the administrative and technical challenges associated with conducting numerous, interleaved screening efforts run by multiple independent research groups.We have developed Screensaver, a free, open source, web-based lab information management system (LIMS), to address the informatics needs of our small molecule and RNAi screening facility. Screensaver supports the storage and comparison of screening data sets, as well as the management of information about screens, screeners, libraries, and laboratory work requests. To our knowledge, Screensaver is one of the first applications to support the storage and analysis of data from both genome-scale RNAi screening projects and small molecule screening projects.The informatics and administrative needs of an HTS facility may be best managed by a single, integrated, web-accessible application such as Screensaver. Screensaver has proven useful in meeting the requirements of the ICCB-Longwood/NSRB Screening Facility at Harvard Medical School, and has provided similar benefits to other HTS facilities.

Publications

  1. Screensaver: an open source lab information management system (LIMS) for high throughput screening facilities.
    Cite this
    Tolopko AN, Sullivan JP, Erickson SD, Wrobel D, Chiang SL, Rudnicki K, Rudnicki S, Nale J, Selfors LM, Greenhouse D, Muhlich JL, Shamu CE, 2010-05-01 - BMC bioinformatics

Credits

  1. Andrew N Tolopko
    Developer

    ICCB-Longwood/NSRB Screening Facility, Harvard Medical School

  2. John P Sullivan
    Developer

  3. Sean D Erickson
    Developer

  4. David Wrobel
    Developer

  5. Su L Chiang
    Developer

  6. Katrina Rudnicki
    Developer

  7. Stewart Rudnicki
    Developer

  8. Jennifer Nale
    Developer

  9. Laura M Selfors
    Developer

  10. Dara Greenhouse
    Developer

  11. Jeremy L Muhlich
    Developer

  12. Caroline E Shamu
    Investigator

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Summary
AccessionBT006394
Tool TypeApplication
Category
PlatformsLinux/Unix
Technologies
User InterfaceTerminal Command Line
Download Count0
Submitted ByCaroline E Shamu