Introduction

UNLABELLED: Mass spectrometry (MS) is widely used for isotopic labeling studies of metabolism and other biological processes. Quantitative applications-e.g. metabolic flux analysis-require tools to correct the raw MS data for the contribution of all naturally abundant isotopes. IsoCor is a software that allows such correction to be applied to any chemical species. Hence it can be used to exploit any isotopic tracer, from well-known ((13)C, (15)N, (18)O, etc) to unusual ((57)Fe, (77)Se, etc) isotopes. It also provides new features-e.g. correction for the isotopic purity of the tracer-to improve the accuracy of quantitative isotopic studies, and implements an efficient algorithm to process large datasets. Its user-friendly interface makes isotope labeling experiments more accessible to a wider biological community. AVAILABILITY: IsoCor is distributed under OpenSource license at http://metasys.insa-toulouse.fr/software/isocor/

Publications

  1. IsoCor: correcting MS data in isotope labeling experiments.
    Cite this
    Millard P, Letisse F, Sokol S, Portais JC, 2012-05-01 - Bioinformatics (Oxford, England)

Credits

  1. Pierre Millard
    Developer

  2. Fabien Letisse
    Developer

  3. Serguei Sokol
    Developer

  4. Jean-Charles Portais
    Investigator

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Summary
AccessionBT006457
Tool TypeApplication
Category
PlatformsLinux/Unix
Technologies
User InterfaceTerminal Command Line
Download Count0
Submitted ByJean-Charles Portais