Introduction

Protein structures are frequently related by spectacular and often surprising similarities. Structural correlations among protein chains are routinely detected by various structure-matching techniques, but the comparison of oligomers and molecular complexes is largely uncharted territory. Here we solve the structure-matching problem for oligomers and large molecular aggregates, including the largest molecular complexes known today. We provide several challenging examples that cannot be handled by conventional structure-matching techniques and we report on a number of remarkable correlations. The examples cover the cell-puncturing device of bacteriophage T4, the secretion system of P. aeruginosa, members of the dehydrogenase family, DNA clamps, ferredoxin iron-storage cages, and virus capsids.

Publications

  1. Detection of spatial correlations in protein structures and molecular complexes.
    Cite this
    Sippl MJ, Wiederstein M, 2012-04-01 - Structure (London, England : 1993)

Credits

  1. Manfred J Sippl
    Developer

    Division of Bioinformatics, Department of Molecular Biology

  2. Markus Wiederstein
    Investigator

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Summary
AccessionBT006498
Tool TypeApplication
Category
PlatformsLinux/Unix
Technologies
User InterfaceTerminal Command Line
Download Count0
Submitted ByMarkus Wiederstein