Introduction

Sequencing glycan structures is a difficult problem that requires the use of multiple experimental approaches. One powerful approach to glycan sequencing is the combination of liquid chromatography with sequential exoglycosidase digestions; however, interpreting this can be difficult and time-consuming. To aid this process, we introduce GlycoProfileAssigner, software for automated structural assignment of glycan profile data from liquid chromatography experiments.GlycoProfileAssigner has been tested on human IgG data, and can retrieve the correct structure in 14 out of 16 peaks tested.The programme and its source code is available at https://bitbucket.org/fergaljd/glycoprofileassigner: pauline.rudd@nibrt.ieSupplementary data are available at Bioinformatics online.

Publications

  1. GlycoProfileAssigner: automated structural assignment with error estimation for glycan LC data.
    Cite this
    Duffy FJ, Rudd PM, 2015-07-01 - Bioinformatics (Oxford, England)

Credits

  1. Fergal J Duffy
    Developer

    National Institute for Bioprocessing Research and Training, Fosters Avenue, Ireland

  2. Pauline M Rudd
    Investigator

    National Institute for Bioprocessing Research and Training, Fosters Avenue, Ireland

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Summary
AccessionBT006634
Tool TypeApplication
Category
PlatformsLinux/Unix
Technologies
User InterfaceTerminal Command Line
Download Count0
Country/RegionIreland
Submitted ByPauline M Rudd