Introduction

The alignment of sequencing reads against a protein reference database is a major computational bottleneck in metagenomics and data-intensive evolutionary projects. Although recent tools offer improved performance over the gold standard BLASTX, they exhibit only a modest speedup or low sensitivity. We introduce DIAMOND, an open-source algorithm based on double indexing that is 20,000 times faster than BLASTX on short reads and has a similar degree of sensitivity.

Publications

  1. Fast and sensitive protein alignment using DIAMOND.
    Cite this
    Buchfink B, Xie C, Huson DH, 2015-01-01 - Nature methods

Credits

  1. Benjamin Buchfink
    Developer

    Department of Computer Science and Center for Bioinformatics, University of Tübingen, Germany

  2. Chao Xie
    Developer

    1] Singapore Centre on Environmental Life Sciences Engineering, School of Biological Sciences, Singapore

  3. Daniel H Huson
    Investigator

    1] Department of Computer Science and Center for Bioinformatics, University of Tübingen, Singapore

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Summary
AccessionBT006655
Tool TypeApplication
Category
PlatformsLinux/Unix
Technologies
User InterfaceTerminal Command Line
Download Count0
Country/RegionSingapore
Submitted ByDaniel H Huson