Introduction

Genetic screens by CRISPR/Cas9-mediated genome engineering have become a powerful tool for functional genomics. However, there is currently a lack of end-to-end software pipelines to analyze CRISPR/Cas9 screens based on next generation sequencing.The CRISPR-AnalyzeR for pooled screens (caRpools) is an R package for exploratory data analysis that provides a complete workflow to analyze CRISPR/Cas9 screens. To further support the analysis of large-scale screens, caRpools integrates screening documentation and generation of standardized analysis reports.caRpools, manuals and an open virtual appliance are available at http://github.com/boutroslab/caRpools.

Publications

  1. caRpools: an R package for exploratory data analysis and documentation of pooled CRISPR/Cas9 screens.
    Cite this
    Winter J, Breinig M, Heigwer F, Brügemann D, Leible S, Pelz O, Zhan T, Boutros M, 2016-02-01 - Bioinformatics (Oxford, England)

Credits

  1. Jan Winter
    Developer

    German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Heidelberg University, Germany

  2. Marco Breinig
    Developer

    German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Heidelberg University, Germany

  3. Florian Heigwer
    Developer

    German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Heidelberg University, Germany

  4. Dirk Brügemann
    Developer

    German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Heidelberg University, Germany

  5. Svenja Leible
    Developer

    German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Heidelberg University, Germany

  6. Oliver Pelz
    Developer

    German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Heidelberg University, Germany

  7. Tianzuo Zhan
    Developer

    German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Heidelberg University, Germany

  8. Michael Boutros
    Investigator

    German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Heidelberg University, Germany

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Summary
AccessionBT006836
Tool TypeApplication
Category
PlatformsLinux/Unix
TechnologiesR
User InterfaceTerminal Command Line
Download Count0
Country/RegionGermany
Submitted ByMichael Boutros