Dr. Sim Dr.Sim is a general learning-based framework that automatically infers similarity measurement, and can be used to characterize transcriptional profiles for drug discovery with generalized good performance.

Introduction

Dr.Sim is a general learning-based framework that automatically infers similarity measurement, and can be used to characterize transcriptional profiles for drug discovery with generalized good performance. Traditionally, such similarity measurements have been defined in an unsupervised way, and due to the high dimensionality and the existence of high noise in these high-throughput data, they lack robustness with limited performance. We evaluated Dr.Sim on comprehensively publicly available in vitro and in vivo datasets in drug annotation and repositioning using high-throughput transcriptional perturbation data, and indicated that Dr.Sim significantly outperforms the existing methods, and is proven to be a conceptual improvement by learning transcriptional similarity to facilitate the broad utility of high-throughput transcriptional perturbation data for phenotypic drug discovery.

Publications

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Credits

  1. Wei Zhiting 1810546@tongji.edu.cn
    Investigator

    School of Life Sciences Technology, Tongji University, China

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181***6@tongji.edu.cn (September 20, 2021)
Summary
AccessionBT007273
Tool TypeApplication
CategoryDrug repositioning
PlatformsLinux/Unix
TechnologiesPython2, Python3
User InterfaceTerminal Command Line
Input DataFASTQ
Latest Release1.0.0 (September 20, 2021)
Download Count354
Country/RegionChina
Submitted ByWei Zhiting