Cardiovascular Disease Atlas
Data release 1.0
| Disease | Atherosclerosis |
|---|---|
| CVD Atlas ID | CVDD000028 |
| MeSH ID | D050197 |
| Ontology ID | NCIT:C35768 |
| Description [MeSH] | A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA. |
| Dataset | Reported disease | Tissue/cell type | Omics | Data accession |
|---|---|---|---|---|
| CVDS000295 | Atherosclerosis of the extremities (PheCode 440.2) | - | Genomics | GCST90044005 |
| CVDS000296 | Atherosclerosis (PheCode 440) | - | Genomics | GCST90044006 |
| CVDS000506 | Atherosclerosis | Artery | Epigenomics | GSE149759 |
| CVDS000529 | Atherosclerosis | Peripheral blood mononuclear cell | Transcriptomics | GSE230214 |
| CVDS000531 | Atherosclerosis | Macrophage | Transcriptomics | GSE9874 |
| Variant | Gene | Beta | Standard error | P value | Odds ratio | Study | Ancestry | Link |
|---|
| Gene | Tissue | Best coloc SNP | GWAS risk SNP | SNP.PP.H4 | PP.H4.abf | Ancestry | Dataset |
|---|
| Variant | Gene | Description | PMID |
|---|
| Variant | Pre miRNA | Region | Mature miRNA |
ΔG
|
Predict
|
PMID |
|---|
| SNP | Reported disease | Gene | Description | PMID |
|---|
| Reported disease | Gene | Category | Description | Publication |
|---|
| Tissue/cell type | Gene | Reported disease | Alteration | log2FC | P value | Adjusted P value | Method | PMID |
|---|---|---|---|---|---|---|---|---|
| Aorta | COL15A1 | Atherosclerosis | Up | 0.00 | - | - | qRT-PCR | 23912340 |
| Carotid artery segment | SNHG12 | Atherosclerosis | Down | 0.00 | - | - | qPCR | 32075942 |
| Peripheral blood mononuclear cell | CCR7 | Atherosclerosis | Down | 0.00 | - | - | qPCR | 32178422 |
| Peripheral blood mononuclear cell | FOXO1 | Atherosclerosis | Down | 0.00 | - | - | qPCR | 32178422 |
| Tissue/cell type | Gene | Reported disease | Mapped disease | log2FC | P value | Adjusted P value | Method | Dataset |
|---|---|---|---|---|---|---|---|---|
| Macrophage | MT2A | Atherosclerosis | Atherosclerosis | 1.25e+3 | 4.04e-5 | 1.17e-3 | Microarray | CVDS000531 |
| Macrophage | TALDO1 | Atherosclerosis | Atherosclerosis | 1.23e+3 | 1.52e-13 | 4.67e-11 | Microarray | CVDS000531 |
| Macrophage | PLIN2 | Atherosclerosis | Atherosclerosis | 1.09e+3 | 1.07e-17 | 8.88e-15 | Microarray | CVDS000531 |
| Macrophage | PRDX1 | Atherosclerosis | Atherosclerosis | 1.09e+3 | 1.46e-9 | 1.56e-7 | Microarray | CVDS000531 |
| Macrophage | APOC1 | Atherosclerosis | Atherosclerosis | 1.05e+3 | 6.51e-6 | 2.57e-4 | Microarray | CVDS000531 |
| Macrophage | MT1H | Atherosclerosis | Atherosclerosis | 926 | 3.91e-5 | 1.15e-3 | Microarray | CVDS000531 |
| Macrophage | TXNRD1 | Atherosclerosis | Atherosclerosis | 730 | 4.04e-13 | 1.09e-10 | Microarray | CVDS000531 |
| Macrophage | AKR1B1 | Atherosclerosis | Atherosclerosis | 636 | 1.75e-7 | 1.17e-5 | Microarray | CVDS000531 |
| Macrophage | ANXA1 | Atherosclerosis | Atherosclerosis | 630 | 1.18e-5 | 4.33e-4 | Microarray | CVDS000531 |
| Macrophage | UBB | Atherosclerosis | Atherosclerosis | 620 | 1.76e-3 | 2.50e-2 | Microarray | CVDS000531 |
| Gene | Gene type | Species | Reported disease | Score | PMID | Gene link |
|---|
| Reported disease | Tissue | Gene | Effect size | P value | Method | Publication | PMID | Gene link |
|---|
| Reported disease | Gene | Category | Description | Publication |
|---|
| Reported disease | Gene | Species | Description | Publication |
|---|
| Name | Gene | Relation to gene | Tissue | Reported disease | Delta beta | P value | Adjusted P value | Dataset | GEO accession |
|---|
| Name | Gene | Relation to gene | Reported disease | Delta beta | P value | Adjusted P value | Tissue | PMID |
|---|
| Reported disease | Gene | Category | Description | Publication |
|---|
| Reported disease | Gene | Species | Description | Publication |
|---|
| Gene | Protein | Average log2FC | P value | Dataset |
|---|
| Metabolite | VIP | Dataset |
|---|
| Chemical name | Chemical ID | Direct evidence | Reported disease | Inference gene | Inference score | #PMIDs | Gene link |
|---|