EDK
Editome Disease Knowledgebase
Hepatocellular Carcinoma
| Disease name | Hepatocellular Carcinoma |
|---|---|
| Classfication | Cancer |
| Related Enzyme(s) | |
| EFO | EFO:0000182 |
| DOID | 684 |
| OMIM | |
| NCI | |
| Definition | A liver carcinoma that has material basis in undifferentiated hepatocytes. |
| Gene symbol | Species | Enzyme | Editing site(s) | Editing Type | PMID | RADAR | REDIportal | Description |
|---|---|---|---|---|---|---|---|---|
| AZIN1 | Human | ADAR1;ADAR2 | 2 | A-to-I | The edited AZIN1 promotes cell proliferation and possibly the Hepatocellular Carcinoma onset and progression. The wild-type AZIN1 could promote the tumorigenicity, the edited AZIN1 conferred gain-of-function phenotypes that were manifested by more aggressive behaviors during Esophageal Squamous Cell Carcinoma progression. | |||
| FLNB | Human | ADAR1;ADAR2 | 1 | A-to-I | In the Hepatocellular Carcinoma samples and Esophageal Squamous Cell Carcinoma samples, FLNB demonstrate a higher editing level compare to the normal sample. | |||
| COPA | Human | ADAR1;ADAR2 | 1 | A-to-I | The hyper-editing of COPA are closely associated with hepatocellular carcinoma pathogenesis. And in the hepatocellular carcinoma samples, COPA editing level is significantly lower than normal samples. The previous study has identified two RNA-editing sites at codon 164 (Ile-Val) of the COPA gene. | |||
| CDK13 | Human | ADAR1 | 2 | A-to-I | The K96R editing site of CDK13 and Q103R, which were specifically modified by ADAR1，were more abundant in HCC tumor tissues and closely associated with poor prognosis of HCC patients. |
| Gene symbol | Disease | Enzyme | Editing Sites | Editing Type | miRBase | PMID | Description |
|---|---|---|---|---|---|---|---|
| hsa-mir-214 | ADAR2 | 2 | U-to-C | MI0000290 | miR-214 frequently deregulate in Hepatocellular Carcinoma. ADAR2-mediate editing event caused a decrease of the RNA transcript complementary to pri-miR-214, which led to the decrease of pri-miR-214 and miR-214 and resulted in the increased protein level of its novel target gene Rab15. RNA editing is a novel mechanism for regulating the biogenesis of specific miRNAs during hepatocarcinogenesis. | ||
| hsa-mir-122 | ADAR2 | 1 | A-to-I | MI0000442 | miR-122 frequently deregulate in HCC. These specific nucleotide changes mainly occurred in the hepatocarcinogenesis tumors but little in the adjacent nontumorous tissues of these patients. |
| Enzyme | Full Name | Location | Ensembl | Targets | Related Diseases | Aliases |
|---|---|---|---|---|---|---|
| APOBEC1 | Apolipoprotein B mRNA editing enzyme catalytic subunit 1 | Chr12:8602166..8612970 |
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| APOBEC3 | Apolipoprotein B mRNA Editing Enzyme Catalytic Subunit 3 | Chr22:38957522..39087743 |
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