Disease - EDK - BIG Data Center

Disease name	Spinal Cord Injury
Classfication	Nervous system disease
Related Enzyme(s)
EFO	-
DOID	-
OMIM	-
NCI	-
Definition	A spinal cord injury is damage to the spinal cord that causes temporary or permanent changes in its function.

Gene symbol	Species	Enzyme	Editing site(s)	Editing Type	PMID	RADAR	REDIportal	Description
GRIA3	Rat	ADAR2	1	A-to-I	20456005			The molecular changes set in motion by SCI that affect the channel properties of AMPA receptors. SCI strongly reduced the level of AMPA receptor R/G editing, the reduced editing at the R/G site of glutamate receptor subunits (GluRs) is likely to reduce post-synaptic excitatory responses to glutamate, thus limiting the progression of cell death; however, prolonged suppression of GluR function in later stages may hinder synaptic plasticity.
GRIA4	Rat	ADAR2	1	A-to-I	20456005			The molecular changes set in motion by SCI that affect the channel properties of AMPA receptors. SCI strongly reduced the level of AMPA receptor R/G editing, the reduced editing at the R/G site of glutamate receptor subunits (GluRs) is likely to reduce post-synaptic excitatory responses to glutamate, thus limiting the progression of cell death; however, prolonged suppression of GluR function in later stages may hinder synaptic plasticity.