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MethBank 3.4 scMethBank EWAS Open Platform
Release 4.0 (2022-09)
MethBank
A database of DNA methylation across a variety of species

MethBank

A database of DNA methylation across a variety of species
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cfDNA Module
The cfDNA module integrates WGBS-based cfDNA methylation, fragmentomics, and cancer-associated DMC profiles to support non-invasive cancer biomarker discovery and clinical translational research.

Cancer Cohort Overview

Cancer Types
--
Excluding normal samples
Total Samples
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Collected from Excel metadata
Total DMCs
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Summarized from 7 cancer DMC lists
Projects
--
Unique study IDs

Cancer Type Selection

Cancer-specific Differential Methylation Landscape

DMCs
--
Cancer-specific differential methylation cytosines
Hyper DMCs
--
Hypermethylated DMCs
Hypo DMCs
--
Hypomethylated DMCs
Related genes
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Genes associated with cancer-specific DMCs
Breast cancer DMC density
Breast cancer DMC chromosome density

Gene Annotation of DMCs

Chromosome Distribution

Genomic Location

GO

KEGG

Gene ID Gene Symbol Chromosome Start Position End Position Length Annotation Differential Methylation Value Sample1 Methylation Level Sample2 Methylation Level JBrowse

Enhancer Annotation of DMCs

Enhancer information
Enhancer Super Enhancer Disease Enhancer Cancer Enhancer Active Enhancer
Tips: we collected 9,447,227 enhancers from ENdb(430), EnhancerAtlas 2.0(7,272,472), SEA(2,174,325), FANTOM5, and VISTA database.
Tips: we collected 106,907 super enhancers from ENdb(50) and SEA(106,857) database.
Tips: we collected 1,397 disease enhancers from diseaseEnhancer database.
Tips: we collected 168,269 cancer enhancers from CancerEND database.
Tips: we collected 1,549,063 active enhancers from HACER database.

Silencer Annotation of DMCs

Silencer information
Tips: we collected 3,559,938 silencers from SilencerDB database.

TFBS Annotation of DMCs

Transcription factor information
Tips: we collected 182,416,820 transcriptional factors from ReMap2022 and JASPAR database.