| Title |
Chromatin accessibility profiling dataset of HCC |
| Description |
Alpha-fetoprotein (AFP) is a widely used canonical biomarker for the incidence or recurrence of hepatocellular carcinoma (HCC). AFP-positive HCC has been intensively investigated; however, the microenvironmental characteristics of AFP-negative HCC remain to be deciphered. We not only uncovered a previously unrecognized AR-mediated hyperactive arachidonic acid microenvironment in AFP-negative HCC, but also revealed AR-11,12-EET-EGFR axis-induced angiogenesis, providing a strategy for combined androgen receptor inhibitor with anti-angiogenic blockade for AFP-negative HCC intervention. |
| Organism |
Homo sapiens |
| Data Type |
Chromatin Accessibility Profiling |
| Data Accessibility |
Controlled-access |
| BioProject |
PRJCA028990 |
| Release Date |
2025-06-07 |
| Submitter |
Ming Kuang (kuangm@mail.sysu.edu.cn) |
| Organization |
The First Affiliated Hospital, Sun Yat-sen University |
| Submission Date |
2024-12-11 |