| Title | Methylome dataset of HCC |
|---|---|
| Description | Alpha-fetoprotein (AFP) is a widely used canonical biomarker for the incidence or recurrence of hepatocellular carcinoma (HCC). AFP-positive HCC has been intensively investigated; however, the microenvironmental characteristics of AFP-negative HCC remain to be deciphered. We not only uncovered a previously unrecognized AR-mediated hyperactive arachidonic acid microenvironment in AFP-negative HCC, but also revealed AR-11,12-EET-EGFR axis-induced angiogenesis, providing a strategy for combined androgen receptor inhibitor with anti-angiogenic blockade for AFP-negative HCC intervention. |
| Organism | Homo sapiens |
| Data Type | Methylation Profiling |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA028990 |
| Release Date | 2025-06-07 |
| Submitter | Ming Kuang (kuangm@mail.sysu.edu.cn) |
| Organization | The First Affiliated Hospital, Sun Yat-sen University |
| Submission Date | 2024-12-11 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX008236-01 | HCC102-Methylation | 1 | Methylation Profiling | 192.93 MB | bismark.cov | Controlled |
| OMIX008236-02 | HCC920-Methylation | 1 | Methylation Profiling | 145.42 MB | bismark.cov | Controlled |
| OMIX008236-03 | HCC453-Methylation | 1 | Methylation Profiling | 181.91 MB | bismark.cov | Controlled |
| OMIX008236-04 | HCC405-Methylation | 1 | Methylation Profiling | 182.09 MB | bismark.cov | Controlled |
| OMIX008236-05 | HCC519-Methylation | 1 | Methylation Profiling | 178.47 MB | bismark.cov | Controlled |
| OMIX008236-06 | HCC757-Methylation | 1 | Methylation Profiling | 191.44 MB | bismark.cov | Controlled |
| OMIX008236-07 | HCC196-Methylation | 1 | Methylation Profiling | 180.87 MB | bismark.cov | Controlled |
| OMIX008236-08 | HCC428-Methylation | 1 | Methylation Profiling | 156.35 MB | bismark.cov | Controlled |
| OMIX008236-09 | HCC599-Methylation | 1 | Methylation Profiling | 186.53 MB | bismark.cov | Controlled |
| OMIX008236-10 | HCC403-Methylation | 1 | Methylation Profiling | 178.55 MB | bismark.cov | Controlled |
| OMIX008236-11 | HCC632-Methylation | 1 | Methylation Profiling | 189.97 MB | bismark.cov | Controlled |
| OMIX008236-12 | HCC452-Methylation | 1 | Methylation Profiling | 176.9 MB | bismark.cov | Controlled |
| OMIX008236-13 | HCC703-Methylation | 1 | Methylation Profiling | 188.89 MB | bismark.cov | Controlled |
| OMIX008236-14 | HCC344-Methylation | 1 | Methylation Profiling | 169.31 MB | bismark.cov | Controlled |
| OMIX008236-15 | HCC311-Methylation | 1 | Methylation Profiling | 174.51 MB | bismark.cov | Controlled |
| OMIX008236-16 | HCC849-Methylation | 1 | Methylation Profiling | 183.36 MB | bismark.cov | Controlled |
| OMIX008236-17 | HCC431-Methylation | 1 | Methylation Profiling | 198.59 MB | bismark.cov | Controlled |
| OMIX008236-18 | HCC541-Methylation | 1 | Methylation Profiling | 187.45 MB | bismark.cov | Controlled |
| OMIX008236-19 | HCC238-Methylation | 1 | Methylation Profiling | 195.5 MB | bismark.cov | Controlled |
| OMIX008236-20 | HCC446-Methylation | 1 | Methylation Profiling | 174.83 MB | bismark.cov | Controlled |
| OMIX008236-21 | HCC515-Methylation | 1 | Methylation Profiling | 174.87 MB | bismark.cov | Controlled |
| OMIX008236-22 | HCC483-Methylation | 1 | Methylation Profiling | 177.53 MB | bismark.cov | Controlled |
| OMIX008236-23 | HCC884-Methylation | 1 | Methylation Profiling | 181.3 MB | bismark.cov | Controlled |
| OMIX008236-24 | HCC422-Methylation | 1 | Methylation Profiling | 185.19 MB | bismark.cov | Controlled |
| OMIX008236-25 | HCC826-Methylation | 1 | Methylation Profiling | 192.96 MB | bismark.cov | Controlled |
| OMIX008236-26 | HCC841-Methylation | 1 | Methylation Profiling | 194.43 MB | bismark.cov | Controlled |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Androgen receptor promotes arachidonic acid metabolism and angiogenic microenvironment in AFP-negative hepatocellular carcinoma | Nature Communications | 2025-07 | OMIX008237 OMIX008236 OMIX008235 OMIX008234 OMIX008233 | Deposit |