| Title |
Post-translational Switch of DHCR24 Acetylation Sustains Sterol Synthesis and Promotes HCC via 7-Ketocholesterol/p62 Axis |
| Description |
Dysregulated cholesterol synthesis links to cancer, but its HCC role is unclear. We find DHCR24 Lys254 acetylation (an HCC hallmark) predicts poor survival. It stabilizes DHCR24, boosts 7-ketocholesterol to upregulate p62, driving HCC growth. FDA-approved irbesartan inhibits DHCR24/its acetylation, suppressing HCC. This defines DHCR24 acetylation as a metabolic switch and the axis as an HCC target. |
| Organism |
Mus |
| Data Type |
Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility |
Open-access |
| BioProject |
PRJCA050350 |
| Release Date |
2025-11-07 |
| Submitter |
Dabin Liu (liudb526@126.com) |
| Organization |
NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy |
| Submission Date |
2025-11-05 |