| Title | Post-translational Switch of DHCR24 Acetylation Sustains Sterol Synthesis and Promotes HCC via 7-Ketocholesterol/p62 Axis |
|---|---|
| Description | Dysregulated cholesterol synthesis links to cancer, but its HCC role is unclear. We find DHCR24 Lys254 acetylation (an HCC hallmark) predicts poor survival. It stabilizes DHCR24, boosts 7-ketocholesterol to upregulate p62, driving HCC growth. FDA-approved irbesartan inhibits DHCR24/its acetylation, suppressing HCC. This defines DHCR24 acetylation as a metabolic switch and the axis as an HCC target. |
| Organism | Mus |
| Data Type | Expression Profiling |
| Data Accessibility | Open-access |
| BioProject | PRJCA050350 |
| Release Date | 2025-11-07 |
| Submitter | Dabin Liu (liudb526@126.com) |
| Organization | NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy |
| Submission Date | 2025-11-05 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX012783-01 | DHCR24 KO RNA-seq | 8 | Expression Profiling | 17.6 MB | xls |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Post-translational switch of DHCR24 acetylation sustains sterol synthesis and promotes HCC via the 7-ketocholesterol/p62 axis | Cell Reports | 2025-12 | OMIX012782 OMIX012783 | Deposit |