A Single-Cell Transcriptomic Landscape of Mouse Testicular Aging
| Title | A Single-Cell Transcriptomic Landscape of Mouse Testicular Aging |
|---|---|
| Description | Advanced paternal age of reproduction is an increasing trend, especially in the developed countries and areas. Yet, a systematic profiling of aging associated testicular molecular and cellular alterations is still missing. Here, we constructed the first single-cell transcriptomic atlases of testes of young and old mice. Further aging-related differentially expressed genes analysis uncovered the disrupted balance of undifferentiated and differentiated spermatogonia stem cells in spermatogonia, indicative of a potential role of spermatogonia stem cells in aging-associated subfertility. Taken together, our findings depict the distinct single-cell transcriptional features of the aged mouse testis, and provide enormous resources for a comprehensive understanding of the cell-type-specific molecular mechanisms underlying mouse testicular aging |
| Organism | Mus musculus |
| Data Type | - |
| Data Accessibility | Open-access |
| BioProject | PRJCA008563 |
| Release Date | 2022-03-08 |
| Submitter | siyu xia (syxbestmayer@whu.edu.cn) |
| Organization | Jinan University |
| Submission Date | 2022-03-07 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX1000-20-01 | young2_matrix | 1 | Transcriptomic | 27.21 MB | matrix.mtx | 0 | |
| OMIX1000-20-02 | young2_features | 1 | Transcriptomic | 284.08 KB | tsv | 0 | |
| OMIX1000-20-03 | old3_matrix | 1 | Transcriptomic | 70.98 MB | matrix.mtx | 0 | |
| OMIX1000-20-04 | old2_features | 1 | Transcriptomic | 284.08 KB | tsv | 0 | |
| OMIX1000-20-05 | old1_barcodes | 1 | Transcriptomic | 31.33 KB | tsv | 0 | |
| OMIX1000-20-06 | young1_barcodes | 1 | Transcriptomic | 38.62 KB | tsv | 0 | |
| OMIX1000-20-07 | young2_barcodes | 1 | Transcriptomic | 15.36 KB | tsv | 0 | |
| OMIX1000-20-08 | old1_features | 1 | Transcriptomic | 284.08 KB | tsv | 0 | |
| OMIX1000-20-09 | young1_features | 1 | Transcriptomic | 284.08 KB | tsv | 0 | |
| OMIX1000-20-10 | old2_barcodes | 1 | Transcriptomic | 42.59 KB | tsv | 0 | |
| OMIX1000-20-11 | old2_matrix | 1 | Transcriptomic | 74.8 MB | matrix.mtx | 0 | |
| OMIX1000-20-12 | old3_barcodes | 1 | Transcriptomic | 34.19 KB | tsv | 0 | |
| OMIX1000-20-13 | old3_features | 1 | Transcriptomic | 284.08 KB | tsv | 0 | |
| OMIX1000-20-14 | young1_matrix | 1 | Transcriptomic | 50.59 MB | matrix.mtx | 0 | |
| OMIX1000-20-15 | old1_matrix | 1 | Transcriptomic | 36.23 MB | matrix.mtx | 0 |