ATP4 - Plant Editosome Database - BIG Data Center

Summary

Editing Factor: ATP4
Synonym: OsATP4; ZmATP4
Description: OsATP4 was also required for the editing of a specific nucleotide in the ribosomal protein S8 transcripts, rps8, and this function was conserved in maize; By contrast, rps8 RNA was edited normally in the maize PROTON gradient regulation3 mutant, pgr3, which also lacks rpl16-rpl14 transcripts, indicating that the editing defect in atp4 mutants is not a secondary effect of altered rpl16-rpl14 RNA metabolism; Expression of the edited rps8 isoform in transgenic osatp4 mutants complemented the cold-sensitive phenotype, indicating that a rps8 expression defect accounts for the cold-sensitivity
Protein Family: PPR
Subclass: P
Construct Structure: P
Gene ID & Species: LOC_Os03g11670 (Oryza sativa)
GRMZM2G128665 (Zea mays)
Edited Gene(s): rps8
Editing Type(s): C-to-U (13)
Publication(s): [1] The PPR-SMR Protein ATP4 Is Required for Editing the Chloroplast mRNA in Rice and Maize., Plant physiology, 2020. [PMID=32928899]

Editing Details

Species Gene ID Organelle Edited Gene Position Region Editing Type Codon Amino Acid Molecular Effect Experiment Details
Oryza sativa LOC_Os03g11670 Chloroplast rps8 182 CDS C-to-U UCA=>UUA S=>L Recoding
Experiment Details
Genotype (Ecotype) Allele Treatment Treatment Detail Mutant Type Phenotype Tissue Development Stage Detection Method Editing Frequency Editing Extent Mutant Effect PMID
DongjinWTControlControlNo mutantNormalSeedlingNAThe amplified PCR products were directly sequenced by Sangon87.01%HighNone32928899
PFG_4A-50341osatp4A T-DNA insertionThermal asymmetric interlaced PCR of the sequences flanking the T-DNA insertion site showed that the T-DNA inserted itself in the coding region, 1,294 bp downstream of the start codon of rice gene Os0HomozygousSeedling blades exhibit an albino phenotype when grown in the cold. The mutants had 13 tillers on average, which was less than that of the wild type (16 tillers). In addition, the mutant exhibited decreases in plant height, panicle length, average grain weight, and yield per plant. The mutant also exhibited reduced leaf width and chlorophyll under natural field conditions. Similarly, a decrease in chlorophyll content was observed in osatp4 when grown at 30°C, however, Fv/Fm, a measure of maximum PSII quantum yield, was unaffected. When grown at 20°C, which confers cold stress on rice (Hasanuzzaman et al., 2018), the chlorophyll content and the Fv/Fm value significantly decreased in osatp4.SeedlingNAThe amplified PCR products were directly sequenced by Sangon0.00%UneditedAbsent32928899
NACOM1ComplementationFor transgene complementation, a 5,617-bp wild-type genomic DNA fragment containing the entire OsATP4 coding region with a 3,156-bp upstream region and a 430-bp downstream sequence was amplified usingHomozygousMutant plants expressing a transgene encoding OsATP4 were restored to the wild-type phenotype.SeedlingNAThe amplified PCR products were directly sequenced by Sangon77.01%HighRestored32928899
NACOM2ComplementationFor transgene complementation, a 5,617-bp wild-type genomic DNA fragment containing the entire OsATP4 coding region with a 3,156-bp upstream region and a 430-bp downstream sequence was amplified usingHomozygousMutant plants expressing a transgene encoding OsATP4 were restored to the wild-type phenotype.SeedlingNAThe amplified PCR products were directly sequenced by Sangon87.95%HighRestored32928899
NACOM3ComplementationFor transgene complementation, a 5,617-bp wild-type genomic DNA fragment containing the entire OsATP4 coding region with a 3,156-bp upstream region and a 430-bp downstream sequence was amplified usingHomozygousMutant plants expressing a transgene encoding OsATP4 were restored to the wild-type phenotype.SeedlingNAThe amplified PCR products were directly sequenced by Sangon93.67%HighRestored32928899
NAcr-osatp4-1CRISPR-induced mutantTo generate CRISPR-mediated alterations in the SMR domain of OsATP4, the targeting sequences were designed. The target-site sequences were cloned into the single guide RNA expression cassette pYLgRNA KnockoutTillers in cr-osatp4 are less than that of the wild type. The cr-osatp4 exhibits decreases in plant height, panicle length.SeedlingNAThe amplified PCR products were directly sequenced by Sangon0.00%UneditedAbsent32928899
NAcr-osatp4-2CRISPR-induced mutantTo generate CRISPR-mediated alterations in the SMR domain of OsATP4, the targeting sequences were designed. The target-site sequences were cloned into the single guide RNA expression cassette pYLgRNA KnockoutTillers in cr-osatp4 are less than that of the wild type. The cr-osatp4 exhibits decreases in plant height, panicle length.SeedlingNAThe amplified PCR products were directly sequenced by Sangon0.00%UneditedAbsent32928899
NAcr-osatp4-3CRISPR-induced mutantTo generate CRISPR-mediated alterations in the SMR domain of OsATP4, the targeting sequences were designed. The target-site sequences were cloned into the single guide RNA expression cassette pYLgRNA KnockoutTillers in cr-osatp4 are less than that of the wild type. The cr-osatp4 exhibits decreases in plant height, panicle length.SeedlingNAThe amplified PCR products were directly sequenced by Sangon0.00%UneditedAbsent32928899
NAcr-osatp4-4CRISPR-induced mutantTo generate CRISPR-mediated alterations in the SMR domain of OsATP4, the targeting sequences were designed. The target-site sequences were cloned into the single guide RNA expression cassette pYLgRNA KnockoutTillers in cr-osatp4 are less than that of the wild type. The cr-osatp4 exhibits decreases in plant height, panicle length.SeedlingNAThe amplified PCR products were directly sequenced by Sangon0.00%UneditedAbsent32928899
NAcr-osatp4-5CRISPR-induced mutantTo generate CRISPR-mediated alterations in the SMR domain of OsATP4, the targeting sequences were designed. The target-site sequences were cloned into the single guide RNA expression cassette pYLgRNA KnockoutTillers in cr-osatp4 are less than that of the wild type. The cr-osatp4 exhibits decreases in plant height, panicle length.SeedlingNAThe amplified PCR products were directly sequenced by Sangon0.00%UneditedAbsent32928899
NAcr-osatp4-6CRISPR-induced mutantTo generate CRISPR-mediated alterations in the SMR domain of OsATP4, the targeting sequences were designed. The target-site sequences were cloned into the single guide RNA expression cassette pYLgRNA KnockoutTillers in cr-osatp4 are less than that of the wild type. The cr-osatp4 exhibits decreases in plant height, panicle length.SeedlingNAThe amplified PCR products were directly sequenced by Sangon0.00%UneditedAbsent32928899
Zea mays GRMZM2G128665 Chloroplast rps8 182 CDS C-to-U UCA=>UUA S=>L Recoding
Experiment Details
Genotype (Ecotype) Allele Treatment Treatment Detail Mutant Type Phenotype Tissue Development Stage Detection Method Editing Frequency Editing Extent Mutant Effect PMID
NAWTControlControlNo mutantNANANAThe amplified PCR products were directly sequenced by Sangon100.00%CompleteNone32928899
NAzmatp4-3/2NANANANANANAThe amplified PCR products were directly sequenced by Sangon0.00%UneditedAbsent32928899
Last update: Jul 2021 (version 1.0)