| Editing Factor: | COD1 |
| Synonym: | CYTOCHROME C OXIDASE DEFICIENT 1 |
| Description: | cod1 mutants are defective in C-to-U editing events in cytochrome oxidase subunit2 and NADH dehydrogenase subunit4 transcripts, encoding subunits of respiratory complex IV and I, respectively, and consequently lacked cytochrome c oxidase activity; Respiratory oxygen consumption by cod1 plantlets is exclusively associated with alternative oxidase activity and that alternative NADH dehydrogenases are also up-regulated in these plants; The metabolomics pattern of cod1 mutants was also deeply altered, suggesting that alternative metabolic pathways compensated for the probable resulting restriction in NADH oxidation; Being the first complex IV-deficient mutants described in higher plants, cod1 lines should be instrumental to future studies on respiration homeostasis |
| Protein Family: | PPR |
| Subclass: | E+ |
| Construct Structure: | PLS-E-E+ |
| Gene ID & Species: | AT2G35030 (Arabidopsis thaliana) |
| Edited Gene(s): | cox2 nad4 |
| Editing Type(s): | C-to-U (21) |
| Publication(s): |
[1] The Analysis of the Editing Defects in the Mutant Provides New Clues for the Prediction of RNA Targets of Arabidopsis E+-Class PPR Proteins., Plants (Basel, Switzerland), 2020. [PMID=32098170] [2] Multiple PPR protein interactions are involved in the RNA editing system in mitochondria and plastids., Proceedings of the National Academy of Sciences of the United States of America, 2017. [PMID=28761003] [3] Disruption of the CYTOCHROME C OXIDASE DEFICIENT1 gene leads to cytochrome c oxidase depletion and reorchestrated respiratory metabolism in Arabidopsis., Plant physiology, 2014. [PMID=25301889] |
| Species | Gene ID | Organelle | Edited Gene | Position | Region | Editing Type | Codon | Amino Acid | Molecular Effect | Experiment Details | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Arabidopsis thaliana | AT2G35030 | Mitochondrion | cox2 | 253 | CDS | C-to-U | CGG=>UGG NA=>NA |
R=>W NA=>NA |
Recoding NA |
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| Arabidopsis thaliana | AT2G35030 | Mitochondrion | cox2 | 698 | CDS | C-to-U | ACG=>AUG NA=>NA |
T=>M NA=>NA |
Recoding NA |
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| Arabidopsis thaliana | AT2G35030 | Mitochondrion | nad4 | 1129 | CDS | C-to-U | CUC=>UUC NA=>NA |
L=>F NA=>NA |
Recoding NA |
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