Plant
Editosome
Database
Summary
| Editing Factor: | CRR22 |
| Synonym: | CHLORORESPIRATORY REDUCTION 22 |
| Description: | The DYW proteins CHLORORESPIRATORY REDUCTION22 (CRR22) and CRR28 are required for editing of multiple plastid transcripts but that their DYW motifs are dispensable for editing activity in vivo; Replacement of the DYW motifs of CRR22 and CRR28 by that of CRR2, which has been shown to be capable of endonucleolytic cleavage, blocks the editing activity of both proteins; In return, the DYW motifs of neither CRR22 nor CRR28 can functionally replace that of CRR2; Different DYW family members have acquired distinct functions in the divergent processes of RNA maturation, including RNA cleavage and RNA editing; Recombinant CRR22 specifically bound to the -20 to 0 regions of the ndhB-7 and ndhD-5 sites and to the -17 to 0 region of the rpoB-3 site; OTP82 and CRR22 act as site-specificity factors at multiple sites in plastids; The high-affinity binding of CRR22 to unrelated cis-acting elements suggests that only certain specific nucleotides in a cis-acting element are sufficient for high-affinity binding of a PPR protein |
| Protein Family: | Pentatricopeptide repeat (PPR) protein |
| Subclass: | DYW |
| Physical Interaction: | NA |
| Construct Structure: | PLS-E-DYW |
| Gene ID & Species: | AT1G11290 (Arabidopsis thaliana) |
| Edited Gene(s): | ndhB ndhD rpoB |
| Editing Type(s): | C-to-U (36) |
| Publication(s): |
[1] Multiple PPR Protein Interactions Are Involved in the RNA Editing System in Arabidopsis Mitochondria and Plastids, Proc Natl Acad Sci U S A, 2017. [doi:10.1073/pnas.1705815114] [2] A pentatricopeptide repeat protein acts as a site-specificity factor at multiple RNA editing sites with unrelated cis-acting elements in plastids, Nucleic Acids Research, 2012. [doi:10.1093/nar/gks164] [3] Pentatricopeptide repeat proteins with the DYW motif have distinct molecular functions in RNA editing and RNA cleavage in Arabidopsis chloroplasts, The Plant Cell, 2009. [doi:10.1105/tpc.108.064667] |
Editing Details
| Species | Gene ID | Organelle | Edited Gene | Position | Region | Nuclear Genome | Organelle Genome | Other Region | Other Position | Editing Type | Codon | Amino Acid | Molecular Effect | Experiment Details | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Arabidopsis thaliana | AT1G11290 | Chloroplast Plastid |
ndhB | 746 | CDS | Arabidopsis Genome Initiative NA |
AP000423 NA |
NA | NA | C-to-U | UCU=>UUU NA=>NA |
S=>F NA=>NA |
Recoding NA |
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| Arabidopsis thaliana | AT1G11290 | Chloroplast Plastid |
ndhD | 887 | CDS | Arabidopsis Genome Initiative NA |
AP000423 NA |
NA | NA | C-to-U | CCC=>CUC NA=>NA |
P=>L NA=>NA |
Recoding NA |
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| Arabidopsis thaliana | AT1G11290 | Chloroplast Plastid |
rpoB | 551 | CDS | Arabidopsis Genome Initiative NA |
AP000423 NA |
NA | NA | C-to-U | UCA=>UUA NA=>NA |
S=>L NA=>NA |
Recoding NA |
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Last update: Sep 2026
(version 2.0)