MEF46 - Plant Editosome Database - CNCB-NGDC

MEF46 - Plant Editosome Database - CNCB-NGDC

Summary

Editing Factor:	MEF46
Synonym:	MITOCHONDRIAL EDITING FACTOR 46
Description:	The defective editing site in mef46, nad5-1958, overlaps with the affected sites in dyw2 mutants, while that in mef47, nad3-64 and ccmC-614 do not, further supporting the specific functional connection between E+ subclass PPR proteins and DYW2
Protein Family:	Pentatricopeptide repeat (PPR) protein
Subclass:	E+
Physical Interaction:	DYW2
Construct Structure:	PLS-E1-E2-E+
Gene ID & Species:	AT2G17210 (Arabidopsis thaliana)
Edited Gene(s):	nad5
Editing Type(s):	C-to-U (3)
Publication(s):	[1] MEF46 and MEF47 are novel specificity factors for RNA editing sites in mitochondrial nad transcripts, Mitochondrion, 2020. [doi:10.1016/j.mito.2020.05.002]

Editing Details

Species

Gene ID

Organelle

Edited Gene

Position

Region

Nuclear Genome

Organelle Genome

Other Region

Other Position

Editing Type

Codon

Amino Acid

Molecular Effect

Experiment Details

Arabidopsis thaliana

AT2G17210

Mitochondrion

1958

CDS

NA

NA

NA

NA

C-to-U

NA=>NA

NA=>NA

NA

**Experiment Details**
Genotype (Ecotype)	Allele	Treatment	Treatment Detail	Mutant Type	Phenotype	Tissue	Development Stage	Detection Method	Editing Frequency	Editing Extent	Mutant Effect	PMID
Columbia	Col-0	Control	Control	No mutant	Normal	Leaf	3-week-old plantlets	Direct cDNA sequencing and RT-PCR	100.00%	Complete	None	32439621
SALK_059706	mef46-1	A T-DNA Insertion	Location of the T-DNA insertions in the mutant and its respective left borders(LB) is at the second S motif from ATG.	Homozygous	The mef46-1 line showed an overall normal growth phenotype comparable to the wild type plant under standard growth chamber conditions.	Leaf	3-week-old plantlets	Direct cDNA sequencing and RT-PCR	0.00%	Unedited	Absent	32439621
SALK_059706	mef46-1+35S:MEF46(1)	Complemented	Location of the T-DNA insertions in the mutant and its respective left borders(LB) is at the second S motif from ATG. Overexpression of the MEF46 locus under the 35S promoter in the mef46-1 mutant lin	Homozygous	Normal	Leaf	3-week-old plantlets	Direct cDNA sequencing and RT-PCR	100.00%	Complete	Restored	32439621

Last update: Sep 2026 (version 2.0)