PpPPR_71 - Plant Editosome Database - BIG Data Center

Summary

Editing Factor: PpPPR_71
Synonym: Phypa_181369
Description: Encoding an RNA-binding protein that acts as a site recognition factor required for RNA editing of the ccmFc transcript; This assay showed that both E and DYW domains are required for RNA editing at the target sites, and that the conserved zinc-binding signature and the terminal triplet of the DYW domain are essential for editing
Protein Family: PPR
Subclass: DYW
Construct Structure: DYW, PLS-DYW, PLS-E-DYW
Gene ID & Species: NA (Physcomitrium patens)
PP1S48_253V6 (Physcomitrium patens)
Edited Gene(s): ccmFc
Editing Type(s): C-to-U (17)
Publication(s): [1] The DYW Domains of Pentatricopeptide Repeat RNA Editing Factors Contribute to Discriminate Target and Non-Target Editing Sites., Plant & cell physiology, 2018. [PMID=29718364]
[2] Two DYW subclass PPR proteins are involved in RNA editing of ccmFc and atp9 transcripts in the moss Physcomitrella patens: first complete set of PPR editing factors in plant mitochondria., Plant & cell physiology, 2013. [PMID=24058147]
[3] The moss pentatricopeptide repeat protein with a DYW domain is responsible for RNA editing of mitochondrial ccmFc transcript., The Plant journal : for cell and molecular biology, 2010. [PMID=20163555]

Editing Details

Species Gene ID Organelle Edited Gene Position Region Editing Type Codon Amino Acid Molecular Effect Experiment Details
Physcomitrium patens NA Mitochondrion ccmFc 122 CDS C-to-U NA=>NA NA=>NA NA
Experiment Details
Genotype (Ecotype) Allele Treatment Treatment Detail Mutant Type Phenotype Tissue Development Stage Detection Method Editing Frequency Editing Extent Mutant Effect PMID
NAWTWild TypeWild TypeNo mutantNAProtonema4-day-oldDirect sequencing was performed on the cDNA79.17%HighNone29718364
NA△71 6-11Knockout (KO) lineProcedures to obtain moss lines PpPPR_56 KO (Δ56-22) and PpPPR_71 KO (Δ71 6-11) have been previously described (Ohtani et al. 2010, Tasaki et al. 2010).KnockoutNAProtonema4-day-oldDirect sequencing was performed on the cDNA0.00%UneditedAbsent29718364
NA71FLComplementationFull-length (FL) version of PpPPR_71 was transformed into the respective KO moss background.KnockoutNAProtonema4-day-oldDirect sequencing was performed on the cDNA84.09%HighRestored29718364
NA71△DYWComplementationTruncated version (ΔDYW) of PpPPR_71 was transformed into the respective KO moss background.KnockoutNAProtonema4-day-oldDirect sequencing was performed on the cDNA0.00%UneditedAbsent29718364
NA71△EComplementationTruncated version (ΔE) of PpPPR_71 was transformed into the respective KO moss background.KnockoutNAProtonema4-day-oldDirect sequencing was performed on the cDNA0.00%UneditedAbsent29718364
NA71PPR+71E/71DYWComplementationTwo editing mutants were transformed by various constructs obtained by swapping from the E and/or DYW domains of PpPPR_56 or PpPPR_71 to the cognate region of another P. patens editing factor.KnockoutNAProtonema4-day-oldDirect sequencing was performed on the cDNA80.00%HighRestored29718364
NA71PPR+71E/45DYWComplementationTwo editing mutants were transformed by various constructs obtained by swapping from the E and/or DYW domains of PpPPR_56 or PpPPR_71 to the cognate region of another P. patens editing factor.KnockoutNAProtonema4-day-oldDirect sequencing was performed on the cDNA0.00%UneditedAbsent29718364
NA71PPR+71E/56DYWComplementationTwo editing mutants were transformed by various constructs obtained by swapping from the E and/or DYW domains of PpPPR_56 or PpPPR_71 to the cognate region of another P. patens editing factor.KnockoutNAProtonema4-day-oldDirect sequencing was performed on the cDNA0.00%UneditedAbsent29718364
NA71PPR+71E/77DYWComplementationTwo editing mutants were transformed by various constructs obtained by swapping from the E and/or DYW domains of PpPPR_56 or PpPPR_71 to the cognate region of another P. patens editing factor.KnockoutNAProtonema4-day-oldDirect sequencing was performed on the cDNA0.00%UneditedAbsent29718364
NA71M1ComplementationTo investigate their roles in RNA editing, we generated transgenic lines with mutated DYW domains in which the HxExnCxxC signature was changed to AxAxnCxxC (56M1 and 71M1) and HxExnAxxA (56M2 and 71M2KnockoutNAProtonema4-day-oldDirect sequencing was performed on the cDNA0.00%UneditedAbsent29718364
NA71M2ComplementationTo investigate their roles in RNA editing, we generated transgenic lines with mutated DYW domains in which the HxExnCxxC signature was changed to AxAxnCxxC (56M1 and 71M1) and HxExnAxxA (56M2 and 71M2KnockoutNAProtonema4-day-oldDirect sequencing was performed on the cDNA0.00%UneditedAbsent29718364
NA71M3ComplementationTo investigate their roles in RNA editing, we generated transgenic lines with mutated DYW domains in which the HxExnCxxC signature was changed to AxAxnCxxC (56M1 and 71M1) and HxExnAxxA (56M2 and 71M2KnockoutNAProtonema4-day-oldDirect sequencing was performed on the cDNA0.00%UneditedAbsent29718364
Physcomitrium patens PP1S48_253V6 Mitochondrion ccmFc 122 CDS C-to-U UCU=>UUU S=>F Recoding
Experiment Details
Genotype (Ecotype) Allele Treatment Treatment Detail Mutant Type Phenotype Tissue Development Stage Detection Method Editing Frequency Editing Extent Mutant Effect PMID
NA6-11Polyethylene Glycolmediated TransformationNAKnockoutSignificantly poor growth of the protonemataProtonema4 daysDirect Sequencing of PCR Products0.00%UneditedAbsent20163555
NA7-9Biolistic TransformationNAKnockoutSignificantly poor growth of the protonemataProtonema4 daysDirect Sequencing of PCR Products0.00%UneditedAbsent20163555
NAWTControlControlControlNormalProtonema4 daysDirect Sequencing of PCR Products82.40%HighNone20163555
NAWTControlControlControlNormalProtonema4 daysDirect Sequencing of PCR Products80.00%HighNone24058147
NA△71-6-11Polyethylene Glycolmediated TransformationNAKnockoutSevere growth retardation of the moss protonemataProtonema4 daysDirect Sequencing of PCR Products0.00%UneditedAbsent24058147
Last update: Jul 2021 (version 1.0)