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Severe acute respiratory syndrome coronavirus 2 isolate SARS-CoV-2/human/CHN/SH-XG2305-3651/2023 ORF1ab polyprotein (ORF1ab), ORF1a polyprotein (ORF1ab), surface glycoprotein (S), ORF3a protein (ORF3a), envelope protein (E), membrane glycoprotein (M), ORF6 protein (ORF6), ORF7a protein (ORF7a), ORF7b (ORF7b), ORF8 protein (ORF8), nucleocapsid phosphoprotein (N), and ORF10 protein (ORF10) genes, complete cds.

GenBase:
C_AA014298.1

LOCUS       C_AA014298             29766 bp    ss-RNA  linear   VRL 11-MAY-2023
DEFINITION  Severe acute respiratory syndrome coronavirus 2 isolate
            SARS-CoV-2/human/CHN/SH-XG2305-3651/2023 ORF1ab polyprotein
            (ORF1ab), ORF1a polyprotein (ORF1ab), surface glycoprotein (S),
            ORF3a protein (ORF3a), envelope protein (E), membrane glycoprotein
            (M), ORF6 protein (ORF6), ORF7a protein (ORF7a), ORF7b (ORF7b), ORF8
            protein (ORF8), nucleocapsid phosphoprotein (N), and ORF10 protein
            (ORF10) genes, complete cds.
ACCESSION   C_AA014298
VERSION     C_AA014298.1
KEYWORDS    .
SOURCE      Severe acute respiratory syndrome coronavirus 2
  ORGANISM  Severe acute respiratory syndrome coronavirus 2
            Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
            Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
            Betacoronavirus; Sarbecovirus; Severe acute respiratory
            syndrome-related coronavirus.
REFERENCE   1  (bases 1 to 29766)
  AUTHORS   Zhang,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-MAY-2023) Microbe lab, Shanghai Municipal Center for
            Disease Control & Prevention, west zhongshan road 1380, Shanghai
            200336, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method       :: Consensus sequence method v. 940-000133-00
            Sequencing Technology :: MGISEQ-200
            ##Genome-Assembly-Data-END##
            .
FEATURES             Location/Qualifiers
     source          1..29766
                     /organism="Severe acute respiratory syndrome coronavirus 2"
                     /mol_type="genomic RNA"
                     /isolate="SARS-CoV-2/human/CHN/SH-XG2305-3651/2023"
                     /isolation_source="Nasopharyngeal swab"
                     /host="Homo sapiens; Host_age: 8; Host_sex: Female"
                     /country="China:Shanghai"
                     /collection_date="2023-04-27"
                     /note="Passage_details/history: Original"
     gene            242..21513
                     /gene="ORF1ab"
     CDS             join(242..13426,13426..21513)
                     /gene="ORF1ab"
                     /ribosomal_slippage
                     /codon_start=1
                     /product="ORF1ab polyprotein"
                     /protein_id="C_AAB30347.1"
                     /translation="MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQH
                     LKDGTCGLVEVEKGVLPQLEQPYVFIKRSDARTAPHVVELVAELEGIQYGRSGETLGVL
                     VPYVGEIPVAYRKVLLRKNGNKGAGGHRYGADLKSFDLGDELGTDPYEDFQENWNTKHS
                     SGVTRELMRELNGGAYTRYVDNNFCGPDGYPLECIKDLLARAGKASCTLSEQLDFIDTK
                     RGVYCCREHEHEIAWYTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTI
                     QPRVEKKKLDGFMGRIRSVYPVASPNECNQMCLSTLMKCDHCGETSWQTGDFVKATCEF
                     CGTENLTKEGATTCGYLPQNAVVKIYCPACHNSEVGPEHSLAEYHNESGLKTILRKGGR
                     TIAFGGCVFSYVGCHNKCAYWVPRASANIGCNHTGVVGEGSEGLNDNLLEILQKEKVNI
                     NIVGDFKLNEEIAIILASFSASTSAFVETVKGLDYKAFKQIVESCGNFKVTKGKAKKGA
                     WNIGEQKSILSPLYAFASEAARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLR
                     LIDAMMFTSDLATNNLVVMAYITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEKFKEG
                     VEFLRDGWEIVKFISTCACEIVGGQIVTCAKEIKESVQTFFKLVNKFLALCADSIIIGG
                     AKLKALNLGETFVTHSKGLYRKCVKSREETGLLMPLKAPKEIIFLEGETLPTEVLTEEV
                     VLKTGDLQPLEQPTSEAVEAPLVGTPVCINGLMLLEIKDTEKYCALAPNMMVTNNIFTL
                     KGGAPTKVTFGDDTVIEVQGYKSVNIIFELDERIDKVLNEKCSAYTVELGTEVNEFACV
                     VADAVIKTLQPVSELLTPLGIDLDEWSMATYYLFDESGEFKLASHMYCSFYPPDEDEEE
                     GDCEEEEFEPSTQYEYGTEDDYQGKPLEFGATSAALQPEEEQEEDWLDDDSQQTVGQQD
                     GSEDNQTTTIQTIVEVQPQLEMELTPVVQTIEVNSFSGYLKLTDNVYIKNADIVEEAKK
                     VKPTVVVNAANVYLKHGGGVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNL
                     AKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTV
                     RTNVYLAVFDKNLYDKLVSSFLEMKSEKQVEQKIAEIPKEEVKPFITESKPLVEQRKQD
                     DKKIKACVEEVTTTLEETKFLTENLLLYIDINGNLHPDSATLVSDIDITFLKKDAPYIV
                     GDVVQEGVLTAVVIPTKKASGTTEMLAKALRKVPTDNYITTYPGQGLNGYTVEEAKTVL
                     KKCKSAFYILPSIISNEKQEILGTVSWNLREMLAHAEETRKLMPVCVETKAIVSTIQRK
                     YKGIKIQEGVVDYGARFYFYTSKTTVASLINTLNDLNETLVTMPLGYVTHGLNLEEAAR
                     YMRSLKVPATVSVSSPDAVTAYNGYLTSSSKTPEEHFIETISLAGSYKDWSYSGQSTQL
                     GIEFLKRGDKSVYYTSNPTTFHLDGEVITFDNLKTLLSLREVRTIKVFTTVDNINLHTQ
                     VVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGKTFYVLPNDDTLRVEAFEYYHTTDSS
                     FLGRYMSALNHTKKWKYPQVNGLTSIKWADNNCYLATALLTLQQIELKFNPPALQDAYY
                     RARAGEAANFCALILAYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQ
                     TTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFVMMSAPPAQYELKH
                     GTFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDVFYKENSYTTTI
                     KPVTYKLDGVVCTEIDPKLDNYYKKDNSYFTEQPIDLVPNQPYPNASFDNFKFVCDNIK
                     FADDLNQLTGYKKPASRELKVTFFPDLNGDVVAIDYKHYTPSFKKGAKLLHKPIVWHVN
                     NATNKATYKPNTWCIRCLWSTKPVETSNSFDVLKSEDAQGMDNLACEDLKPVSEEVVEN
                     PTIQKDVLECNVKTTEVVGDIILKPANNSLKITEEVGHTDLMAAYVDNSSLTIKKPNEL
                     SRVLGLKTLATHGLAAVNSVPWDTIANYAKPFLNKVVSTTTNIVTRCLNRVCTNYMPYF
                     FTLLLQLCTFTRSTNSRIKASMPTTIAKNTVKSVGKFCLEASFNYLKSPNFSKLINIII
                     WFLLLSVCLGSLIYSTAALGVLMSNLGMPSYCTGYREGYLNSTNVTIATYCTGSIPCSV
                     CLSGLDSLDTYPSLETIQITISSFKWDLTAFGLVAEWFLAYILFTRFFYVLGLAAIMQL
                     FFSYFAVHFISNSWLMWLIINLVQMAPISAMVRMYIFFASFYYVWKSYVHVVDGCNSST
                     CMMCYKRNRATRVECTTIVNGVRRSFYVYANGGKGFCKLHNWNCVNCDTFCAGSTFISD
                     EVARDLSLQFKRPINPTDQSSYIVDSVTVKNGSIHLYFDKAGQKTYERHSLSHFVNLDN
                     LRANNTKGSLPINVIVFDGKSKCEESSAKSASVYYSQLMCQPILLLDQALVSDVGDSAE
                     VAVKMFDAYVNTFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTFISAARQGFVDS
                     DVETKDVVECLKLSHQSDIEVTGDSCNNYMLTYNKVENMTPRDLGACIDCSARHINAQV
                     AKSHNIALIWNVKDFMSLSEQLRKQIRSAAKKNNLPFKLTCATTRQVVNVVTTKIALKG
                     GKIVNNWLKQLIKVTLVFLFVAAIFYLITPVHVMSKHTDFSSEIIGYKAIDGGVTRDIA
                     STDTCFANKHADFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTILRTTNGD
                     FLHFLPRVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPYCYDTNVL
                     EGSVAYESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSEYCRHGTCERSEAGVCV
                     STSGRWVLNNDYYRSLPGVFCGVDAVNLFTNMFTPLIQPIGALDISASIVAGGIVAIVV
                     TCLAYYFMRFRRAFGEYSHVVAFNTLLFLMSFIVLCLTPVYSFLPGVYSVIYLYLTFYL
                     TNDVSFLAHIQWMVMFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFSTF
                     EEAALCTFLLNKEMYLKLRSDVLLPFTQYNRYLALYNKYKYFSGAMDTTSYREAACCHL
                     AKALNDFSNSGSDVLYQPPQISITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGL
                     WLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKL
                     KVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRHNFTIKGSFLNGSCGSV
                     GFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAW
                     LYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCA
                     SLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQSAVKRTIKGTHHWLLLTIL
                     TSLLVLVQSTQWSLFFFLYENAFLPFAMGIIAMSAFAMIFVKHKHAFLCLFLLPSLATV
                     AYFNMVYMPASWVMRIMTWLDMVDTSLKLKDCVMYASAVVLLILMTARTVYDDGARRVW
                     TLMNVLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLARGIVFMCVEYCPI
                     FFITGNTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQG
                     LLPPKNSIDAFKLNIKLLGVGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSK
                     LWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQAIA
                     SEFSSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKM
                     ADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLSIIP
                     LTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWEIQQVVDADSKIVQLSEISMDNSPNL
                     AWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNTTKGGRFV
                     LALLSDLQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRG
                     MVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDAAKAYKDYLASGGQPITNCVKMLC
                     THTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCAN
                     DPVGFTLKNTVCTVCGMWKGYGCSCDQLREPMLQSADAQSFLNRVCGVSAARLTPCGTG
                     TSTDVVYRAFDIYNDKVAGFAKFLKTNCCRFQEKDEDDNLIDSYFVVKRHTFSNYQHEE
                     TIYNLLKDCPAVAKHDFFKFRIDGDMVPHISRQRLTKYTMADLVYALRHFDEGNCDTLK
                     EILVTYNCCDDDYFNKKDWYDFVENPDILRVYANLGERVRQALLKTVQFCDAMRNAGIV
                     GVLTLDNQDLNGNWYDFGDFIQTTPGSGVPVVDSYYSLLMPILTLTRALTAESHVDTDL
                     TKPYIKWDLLKYDFTEERLKLFDRYFKYWDQTYHPNCVNCLDDRCILHCANFNVLFSTV
                     FPLTSFGPLVRKIFVDGVPFVVSTGYHFRELGVVHNQDVNLHSSRLSFKELLVYAADPA
                     MHAASGNLLLDKRTTCFSVAALTNNVAFQTVKPGNFNKDFYDFAVSKGFFKEGSSVELK
                     HFFFAQDGNAAISDYDYYRYNLPTMCDIRQLLFVVEVVDKYFDCYDGGCINANQVIVNN
                     LDKSAGFPFNKWGKARLYYDSMSYEDQDALFAYTKRNVIPTITQMNLKYAISAKNRART
                     VAGVSICSTMTNRQFHQKLLKSIAATRGATVVIGTSKFYGGWHNMLKTVYSDVENPHLM
                     GWDYPKCDRAMPNMLRIMASLVLARKHTTCCSLSHRFYRLANECAQVLSEMVMCGSSLY
                     VKPGGTSSGDATTAYANSVFNICQAVTANVNALLSTDGNKIADKYVRNLQHRLYECLYR
                     NRDVDTDFVNEFYAYLRKHFSMMILSDDAVVCFNSTYASQGLVASIKNFKSVLYYQNNV
                     FMSEAKCWTETDLTKGPHEFCSQHTMLVKQGDDYVYLPYPDPSRILGAGCFVDDIVKTD
                     GTLMIERFVSLAIDAYPLTKHPNQEYADVFHLYLQYIRKLHDELTGHMLDMYSVMLTND
                     NTSRYWEPEFYEAMYTPHTVLQAVGACVLCNSQTSLRCGACIRRPFLCCKCCYDHVIST
                     SHKLVLSVNPYVCNAPGCDVTDVTQLYLGGMSYYCKSHKPPISFPLCANGQVFGLYKNT
                     CVGSDNVTDFNAIATCDWTNAGDYILANTCTERLKLFAAETLKATEETFKLSYGIATVR
                     EVLSDRELHLSWEVGKPRPPLNRNYVFTGYRVTKNSKVQIGEYTFEKGDYGDAVVYRGT
                     TTYKLNVGDYFVLTSHTVMPLSAPTLVPQEHYVRITGLYPTLNISDEFSSNVANYQKVG
                     MQKYSTLQGPPGTGKSHFAIGLALYYPSARIVYTACSHAAVDALCEKALKYLPIDKCSR
                     IIPARARVECFDKFKVNSTLEQYVFCTVNALPETTADIVVFDEISMATNYDLSVVNARL
                     CAKHYVYIGDPAQLPAPRTLLTKGTLEPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVD
                     TVSALVYDNKLKAHKDKSAQCFKMFYKGVITHDVSSAINRPQIGVVREFLTRNPAWRKA
                     VFISPYNSQNAVASKILGLPTQTVDSSQGSEYDYVIFTQTTETAHSCNVNRFNVAITRA
                     KVGILCIMSDRDLYDKLQFTSLEIPRRNVATLQAENVTGLFKDCSKVITGLHPTQAPTH
                     LSVDTKFKTEGLCVDVPGIPKDMTYRRLISMMGFKMNYQVNGYPNMFITREEAIRHVRA
                     WIGFDVEGCHATREAVGTNLPLQLGFSTGVNLVAVPTGYVDTPNNTDFSRVSAKPPPGD
                     QFKHLIPLMYKGLPWNVVRIKIVQMLSDTLKNLSDRVVFVLWAHGFELTSMKYFVKIGP
                     ERTCCLCDRRATCFSTASDTYACWHHSIGFDYVYNPFMIDVQQWGFTGNLQSNHDLYCQ
                     VHGNAHVASCDAIMTRCLAVHECFVKRVDWTIEYPIIGDELKINAACRKVQHMVVKAAL
                     LADKFPVLHDIGNPKAIKCVPQADVEWKFYDAQPCSDKAYKIEELFYSYATHSDKFTDG
                     VCLFWNCNVDRYPANSIVCRFDTRVLSNLNLPGCDGGSLYVNKHAFHTPAFDKSAFVNL
                     KQLPFFYYSDSPCESHGKQVVSDIDYVPLKSATCITRCNLGGAVCRHHANEYRLYLDAY
                     NMMISAGFSLWVYKQFDTYNLWNTFTRLQSLENVAFNVVNKGHFDGQQGEVPVSIINNT
                     VYTKVDGVDVELFENKTTLPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYK
                     RDAPAHISTIGVCSMTDIAKKPIETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSV
                     KGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNLQEFKPRS
                     QMEIDFLELAMDEFIERYKLEGYAFEHIVYGDFSHSQLGGLHLLIGLAKRFKESPFELE
                     DFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLDDFVEIIKSQDLSVVSKVVKVTIDYT
                     EISFMLWCKDGHVETFYPKLQSSQAWQPGVAMPNLYKMQRMLLEKCDLQNYGDSATLPK
                     GIMMNVAKYTQLCQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVD
                     SDLNDFVSDADSTLIGDCATVHTANKWDLIISDMYDPKTKNVTKENDSKEGFFTYICGF
                     IQQKLALGGSVAIKITEHSWNADLYKLMGHFAWWTAFVTNVNASSSEAFLIGCNYLGKP
                     REQIDGYVMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKEGQINDMILSL
                     LSKGRLIIRENNRVVISSDVLVNN"
     mat_peptide     242..772
                     /gene="ORF1ab"
                     /product="leader protein"
     mat_peptide     773..2686
                     /gene="ORF1ab"
                     /product="nsp2"
     mat_peptide     2687..8521
                     /gene="ORF1ab"
                     /product="nsp3"
     mat_peptide     8522..10021
                     /gene="ORF1ab"
                     /product="nsp4"
     mat_peptide     10022..10939
                     /gene="ORF1ab"
                     /product="3C-like proteinase"
     mat_peptide     10940..11800
                     /gene="ORF1ab"
                     /product="nsp6"
     mat_peptide     11801..12049
                     /gene="ORF1ab"
                     /product="nsp7"
     mat_peptide     12050..12643
                     /gene="ORF1ab"
                     /product="nsp8"
     mat_peptide     12644..12982
                     /gene="ORF1ab"
                     /product="nsp9"
     mat_peptide     12983..13399
                     /gene="ORF1ab"
                     /product="nsp10"
     mat_peptide     join(13400..13426,13426..16194)
                     /gene="ORF1ab"
                     /product="RNA-dependent RNA polymerase"
     mat_peptide     16195..17997
                     /gene="ORF1ab"
                     /product="helicase"
     mat_peptide     17998..19578
                     /gene="ORF1ab"
                     /product="3'-to-5' exonuclease"
     mat_peptide     19579..20616
                     /gene="ORF1ab"
                     /product="endoRNAse"
     mat_peptide     20617..21510
                     /gene="ORF1ab"
                     /product="2'-O-ribose methyltransferase"
     CDS             242..13441
                     /gene="ORF1ab"
                     /codon_start=1
                     /product="ORF1a polyprotein"
                     /protein_id="C_AAB30351.1"
                     /translation="MESLVPGFNEKTHVQLSLPVLQVRDVLVRGFGDSVEEVLSEARQH
                     LKDGTCGLVEVEKGVLPQLEQPYVFIKRSDARTAPHVVELVAELEGIQYGRSGETLGVL
                     VPYVGEIPVAYRKVLLRKNGNKGAGGHRYGADLKSFDLGDELGTDPYEDFQENWNTKHS
                     SGVTRELMRELNGGAYTRYVDNNFCGPDGYPLECIKDLLARAGKASCTLSEQLDFIDTK
                     RGVYCCREHEHEIAWYTERSEKSYELQTPFEIKLAKKFDTFNGECPNFVFPLNSIIKTI
                     QPRVEKKKLDGFMGRIRSVYPVASPNECNQMCLSTLMKCDHCGETSWQTGDFVKATCEF
                     CGTENLTKEGATTCGYLPQNAVVKIYCPACHNSEVGPEHSLAEYHNESGLKTILRKGGR
                     TIAFGGCVFSYVGCHNKCAYWVPRASANIGCNHTGVVGEGSEGLNDNLLEILQKEKVNI
                     NIVGDFKLNEEIAIILASFSASTSAFVETVKGLDYKAFKQIVESCGNFKVTKGKAKKGA
                     WNIGEQKSILSPLYAFASEAARVVRSIFSRTLETAQNSVRVLQKAAITILDGISQYSLR
                     LIDAMMFTSDLATNNLVVMAYITGGVVQLTSQWLTNIFGTVYEKLKPVLDWLEEKFKEG
                     VEFLRDGWEIVKFISTCACEIVGGQIVTCAKEIKESVQTFFKLVNKFLALCADSIIIGG
                     AKLKALNLGETFVTHSKGLYRKCVKSREETGLLMPLKAPKEIIFLEGETLPTEVLTEEV
                     VLKTGDLQPLEQPTSEAVEAPLVGTPVCINGLMLLEIKDTEKYCALAPNMMVTNNIFTL
                     KGGAPTKVTFGDDTVIEVQGYKSVNIIFELDERIDKVLNEKCSAYTVELGTEVNEFACV
                     VADAVIKTLQPVSELLTPLGIDLDEWSMATYYLFDESGEFKLASHMYCSFYPPDEDEEE
                     GDCEEEEFEPSTQYEYGTEDDYQGKPLEFGATSAALQPEEEQEEDWLDDDSQQTVGQQD
                     GSEDNQTTTIQTIVEVQPQLEMELTPVVQTIEVNSFSGYLKLTDNVYIKNADIVEEAKK
                     VKPTVVVNAANVYLKHGGGVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNL
                     AKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTV
                     RTNVYLAVFDKNLYDKLVSSFLEMKSEKQVEQKIAEIPKEEVKPFITESKPLVEQRKQD
                     DKKIKACVEEVTTTLEETKFLTENLLLYIDINGNLHPDSATLVSDIDITFLKKDAPYIV
                     GDVVQEGVLTAVVIPTKKASGTTEMLAKALRKVPTDNYITTYPGQGLNGYTVEEAKTVL
                     KKCKSAFYILPSIISNEKQEILGTVSWNLREMLAHAEETRKLMPVCVETKAIVSTIQRK
                     YKGIKIQEGVVDYGARFYFYTSKTTVASLINTLNDLNETLVTMPLGYVTHGLNLEEAAR
                     YMRSLKVPATVSVSSPDAVTAYNGYLTSSSKTPEEHFIETISLAGSYKDWSYSGQSTQL
                     GIEFLKRGDKSVYYTSNPTTFHLDGEVITFDNLKTLLSLREVRTIKVFTTVDNINLHTQ
                     VVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGKTFYVLPNDDTLRVEAFEYYHTTDSS
                     FLGRYMSALNHTKKWKYPQVNGLTSIKWADNNCYLATALLTLQQIELKFNPPALQDAYY
                     RARAGEAANFCALILAYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVCKTCGQQQ
                     TTLKGVEAVMYMGTLSYEQFKKGVQIPCTCGKQATKYLVQQESPFVMMSAPPAQYELKH
                     GTFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDVFYKENSYTTTI
                     KPVTYKLDGVVCTEIDPKLDNYYKKDNSYFTEQPIDLVPNQPYPNASFDNFKFVCDNIK
                     FADDLNQLTGYKKPASRELKVTFFPDLNGDVVAIDYKHYTPSFKKGAKLLHKPIVWHVN
                     NATNKATYKPNTWCIRCLWSTKPVETSNSFDVLKSEDAQGMDNLACEDLKPVSEEVVEN
                     PTIQKDVLECNVKTTEVVGDIILKPANNSLKITEEVGHTDLMAAYVDNSSLTIKKPNEL
                     SRVLGLKTLATHGLAAVNSVPWDTIANYAKPFLNKVVSTTTNIVTRCLNRVCTNYMPYF
                     FTLLLQLCTFTRSTNSRIKASMPTTIAKNTVKSVGKFCLEASFNYLKSPNFSKLINIII
                     WFLLLSVCLGSLIYSTAALGVLMSNLGMPSYCTGYREGYLNSTNVTIATYCTGSIPCSV
                     CLSGLDSLDTYPSLETIQITISSFKWDLTAFGLVAEWFLAYILFTRFFYVLGLAAIMQL
                     FFSYFAVHFISNSWLMWLIINLVQMAPISAMVRMYIFFASFYYVWKSYVHVVDGCNSST
                     CMMCYKRNRATRVECTTIVNGVRRSFYVYANGGKGFCKLHNWNCVNCDTFCAGSTFISD
                     EVARDLSLQFKRPINPTDQSSYIVDSVTVKNGSIHLYFDKAGQKTYERHSLSHFVNLDN
                     LRANNTKGSLPINVIVFDGKSKCEESSAKSASVYYSQLMCQPILLLDQALVSDVGDSAE
                     VAVKMFDAYVNTFSSTFNVPMEKLKTLVATAEAELAKNVSLDNVLSTFISAARQGFVDS
                     DVETKDVVECLKLSHQSDIEVTGDSCNNYMLTYNKVENMTPRDLGACIDCSARHINAQV
                     AKSHNIALIWNVKDFMSLSEQLRKQIRSAAKKNNLPFKLTCATTRQVVNVVTTKIALKG
                     GKIVNNWLKQLIKVTLVFLFVAAIFYLITPVHVMSKHTDFSSEIIGYKAIDGGVTRDIA
                     STDTCFANKHADFDTWFSQRGGSYTNDKACPLIAAVITREVGFVVPGLPGTILRTTNGD
                     FLHFLPRVFSAVGNICYTPSKLIEYTDFATSACVLAAECTIFKDASGKPVPYCYDTNVL
                     EGSVAYESLRPDTRYVLMDGSIIQFPNTYLEGSVRVVTTFDSEYCRHGTCERSEAGVCV
                     STSGRWVLNNDYYRSLPGVFCGVDAVNLFTNMFTPLIQPIGALDISASIVAGGIVAIVV
                     TCLAYYFMRFRRAFGEYSHVVAFNTLLFLMSFIVLCLTPVYSFLPGVYSVIYLYLTFYL
                     TNDVSFLAHIQWMVMFTPLVPFWITIAYIICISTKHFYWFFSNYLKRRVVFNGVSFSTF
                     EEAALCTFLLNKEMYLKLRSDVLLPFTQYNRYLALYNKYKYFSGAMDTTSYREAACCHL
                     AKALNDFSNSGSDVLYQPPQISITSAVLQSGFRKMAFPSGKVEGCMVQVTCGTTTLNGL
                     WLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKL
                     KVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRHNFTIKGSFLNGSCGSV
                     GFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAW
                     LYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCA
                     SLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQSAVKRTIKGTHHWLLLTIL
                     TSLLVLVQSTQWSLFFFLYENAFLPFAMGIIAMSAFAMIFVKHKHAFLCLFLLPSLATV
                     AYFNMVYMPASWVMRIMTWLDMVDTSLKLKDCVMYASAVVLLILMTARTVYDDGARRVW
                     TLMNVLTLVYKVYYGNALDQAISMWALIISVTSNYSGVVTTVMFLARGIVFMCVEYCPI
                     FFITGNTLQCIMLVYCFLGYFCTCYFGLFCLLNRYFRLTLGVYDYLVSTQEFRYMNSQG
                     LLPPKNSIDAFKLNIKLLGVGGKPCIKVATVQSKMSDVKCTSVVLLSVLQQLRVESSSK
                     LWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQGAVDINKLCEEMLDNRATLQAIA
                     SEFSSLPSYAAFATAQEAYEQAVANGDSEVVLKKLKKSLNVAKSEFDRDAAMQRKLEKM
                     ADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDNDALNNIINNARDGCVPLSIIP
                     LTTAAKLMVVIPDYNTYKNTCDGTTFTYASALWEIQQVVDADSKIVQLSEISMDNSPNL
                     AWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTACTDDNALAYYNTTKGGRFV
                     LALLSDLQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLYFIKGLNNLNRG
                     MVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDAAKAYKDYLASGGQPITNCVKMLC
                     THTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQIPTTCAN
                     DPVGFTLKNTVCTVCGMWKGYGCSCDQLREPMLQSADAQSFLNGFAV"
     mat_peptide     242..772
                     /gene="ORF1ab"
                     /product="leader protein"
     mat_peptide     773..2686
                     /gene="ORF1ab"
                     /product="nsp2"
     mat_peptide     2687..8521
                     /gene="ORF1ab"
                     /product="nsp3"
     mat_peptide     8522..10021
                     /gene="ORF1ab"
                     /product="nsp4"
     mat_peptide     10022..10939
                     /gene="ORF1ab"
                     /product="3C-like proteinase"
     mat_peptide     10940..11800
                     /gene="ORF1ab"
                     /product="nsp6"
     mat_peptide     11801..12049
                     /gene="ORF1ab"
                     /product="nsp7"
     mat_peptide     12050..12643
                     /gene="ORF1ab"
                     /product="nsp8"
     mat_peptide     12644..12982
                     /gene="ORF1ab"
                     /product="nsp9"
     mat_peptide     12983..13399
                     /gene="ORF1ab"
                     /product="nsp10"
     mat_peptide     13400..13438
                     /gene="ORF1ab"
                     /product="nsp11"
     stem_loop       13434..13461
                     /gene="ORF1ab"
                     /note="Coronavirus frameshifting stimulation element
                     stem-loop 1"
     stem_loop       13446..13500
                     /gene="ORF1ab"
                     /note="Coronavirus frameshifting stimulation element
                     stem-loop 2"
     gene            21521..25333
                     /gene="S"
     CDS             21521..25333
                     /gene="S"
                     /codon_start=1
                     /product="surface glycoprotein"
                     /protein_id="C_AAB30352.1"
                     /translation="MFVFLVLLPLVSSQCVNLITRTQSYTNSFTRGVYYPDKVFRSSVL
                     HSTQDLFLPFFSNVTWFHAIHVSGTNGTKRFDNPVLPFNDGVYFASTEKSNIIRGWIFG
                     TTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLDVYYHENNKSRMESELRVYSSANNC
                     TFEYVSQPFLMDLEGKQGNFKNLREFVFKNIDGYFKIYSKHTPVNLGRDLPQGFSALEP
                     LVDLPIGINITRFQTLLALHRSYLTPGDSSSSWTAGAAAYYVGYLQPRTFLLKYNENGT
                     ITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFHEVFN
                     ATTFASVYAWNRTRISNCVADYSVLYNFAPFFAFKCYGVSPTKLNDLCFTNVYADSFVI
                     RGNEVSQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNKLDSKVSGNYNYLYRLFRKSKL
                     KPFERDISTEIYQAGNKPCNGVAGFNCYSPLQSYGFRPTYGVGHQPYRVVVLSFELLHA
                     PATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDP
                     QTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQGVNCTEVPVAIHADQLTPTWRVYST
                     GSNVFQTRAGCLIGAEYVNNSYECDIPIGAGICASYQTQTKSHRRARSVASQSIIAYTM
                     SLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQY
                     GSFCTQLKRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKYFGGFNFSQILPDPSKPSKR
                     SFIEDLLFNKVTLADAGFIKQYGDCLGDIAARDLICAQKFNGLTVLPPLLTDEMIAQYT
                     SALLAGTITSGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGK
                     IQDSLSSTASALGKLQDVVNHNAQALNTLVKQLSSKFGAISSVLNDILSRLDKVEAEVQ
                     IDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMS
                     FPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFY
                     EPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDI
                     SGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYIWLGFIAGLIAIV
                     MVTIMLCCMTSCCSCLKGCCSCGSCCKFDEDDSEPVLKGVKLHYT"
     gene            25342..26169
                     /gene="ORF3a"
     CDS             25342..26169
                     /gene="ORF3a"
                     /codon_start=1
                     /product="ORF3a protein"
                     /protein_id="C_AAB30353.1"
                     /translation="MDLFMRIFTIGTVTLKQGEIKDATPSDFVRATATIPIQASLPFGW
                     LIVGVALLAVFQSASKIITLKKRWQLALSKGVHFVCNLLLLFVTVYSHLLLVAAGLEAP
                     FLYLYALVYFLQSINFVRIIMRLWLCWKCRSKNPLLYDANYFLCWHTNCYDYCIPYNSV
                     TSSIVITSGDGTTSPISEHDYQIGGYTEKWESGVKDCVVLHSYFTSDYYQLYSTQLSTD
                     IGVEHVIFFIYNKIVDEPEEHVQIHTIDGSSGVVNPVMEPIYDEPTTTTSVPL"
     gene            26194..26421
                     /gene="E"
     CDS             26194..26421
                     /gene="E"
                     /codon_start=1
                     /product="envelope protein"
                     /protein_id="C_AAB30354.1"
                     /translation="MYSFVSEEIGALIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCN
                     IVNVSLVKPSFYVYSRVKNLNSSRVPDLLV"
     gene            26472..27140
                     /gene="M"
     CDS             26472..27140
                     /gene="M"
                     /codon_start=1
                     /product="membrane glycoprotein"
                     /protein_id="C_AAB30355.1"
                     /translation="MADSNGTITVEELKKLLEEWNLVIGFLFLTWICLLQFAYANRNRF
                     LYIIKLIFLWLLWPVTLTCFVLAAVYRINWITGGIAIAMACLVGLMWLSYFIASFRLFA
                     RTRSMWSFNPETNILLNVPLHGTILTRPLLESELVIGAVILRGHLRIAGHHLGRCDIKD
                     LPKEITVATSRTLSYYKLGASQRVAGDSGFAAYSRYRIGNYKLNTDHSSSSDNIALLVQ
                     "
     gene            27151..27336
                     /gene="ORF6"
     CDS             27151..27336
                     /gene="ORF6"
                     /codon_start=1
                     /product="ORF6 protein"
                     /protein_id="C_AAB30356.1"
                     /translation="MFHLVDFQVTIAEILLIIMRTFKVSIWNLDYIINLIIKNLSKSLT
                     ENKYSQLDEEQPMEIL"
     gene            27343..27708
                     /gene="ORF7a"
     CDS             27343..27708
                     /gene="ORF7a"
                     /codon_start=1
                     /product="ORF7a protein"
                     /protein_id="C_AAB30357.1"
                     /translation="MKIILFLALITLATCELYHYQECVRGTTVLLKEPCSSGTYEGNSP
                     FHPLADNKFALTCFSTQFAFACPDGVKHVYQLRARSVSPKLFIRQEEVQELYSPIFLIV
                     AAIVFITLCFTLKRKTE"
     gene            27705..27836
                     /gene="ORF7b"
     CDS             27705..27836
                     /gene="ORF7b"
                     /codon_start=1
                     /product="ORF7b"
                     /protein_id="C_AAB30358.1"
                     /translation="MIELSLIDFYLCFLAFLLFLVLIMLIIFWFSLELQDHNETWHA"
     gene            27843..28208
                     /gene="ORF8"
     CDS             27843..28208
                     /gene="ORF8"
                     /codon_start=1
                     /product="ORF8 protein"
                     /protein_id="C_AAB30348.1"
                     /translation="MKFLVFLGIITTVAAFHQECSLQSCTQHQPYVVDDPCPIHFYSKW
                     YIRVGARKSAPLIELCVDEAGSKSPIQYIDIGNYTVSCLPFTINCQEPKLGSLVVRCSF
                     YQDFLEYHDVRVVLDFI"
     gene            28223..29473
                     /gene="N"
     CDS             28223..29473
                     /gene="N"
                     /codon_start=1
                     /product="nucleocapsid phosphoprotein"
                     /protein_id="C_AAB30349.1"
                     /translation="MSDNGPQNQRNALRITFGGPSDSTGSNQNGGARSKQRRPQGLPNN
                     TASWFTALTQHGKEDLKFPRGQGVPINTNSSPDDQIGYYRRATRRIRGGDGKMKDLSPR
                     WYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQLPQGTT
                     LPKGFYAEGSRGGSQASSRSSSRSRNSSRNSTPGSSKRTSPARMAGNGGDAALALLLLD
                     RLNQLESKMSGKGQQQQGQTVTKKSAAEASKKPRQKRTATKAYNVTQAFGRRGPEQTQG
                     NFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYTGAIKLDDKD
                     PNFKDQVILLNKHIDAYKTFPPTEPKKDKKKKADETQALPQRQKKQQTVTLLPAADLDD
                     FSKQLQQSMSRADSTQA"
     gene            29498..29614
                     /gene="ORF10"
     CDS             29498..29614
                     /gene="ORF10"
                     /codon_start=1
                     /product="ORF10 protein"
                     /protein_id="C_AAB30350.1"
                     /translation="MGYINVFAFPFTIYSLLLCRMNSRNYIAQVDVVNFNLT"
     stem_loop       29549..29584
                     /gene="ORF10"
                     /note="Coronavirus 3' UTR pseudoknot stem-loop 1"
     stem_loop       29569..29597
                     /gene="ORF10"
                     /note="Coronavirus 3' UTR pseudoknot stem-loop 2"
     stem_loop       29668..29682
                     /note="Coronavirus 3' stem-loop II-like motif (s2m)"
ORIGIN
        1 taacaaacca accaactttt gatctcttgt agatctgttc tctaaacgaa ctttaaaatc
       61 tgtgtggctg tcactcggct gcatgcttag tgcactcacg cagtataatt aataactaat
      121 tactgtcgtt gacaggacac gagtaactcg tctatcttct gcaggctgct tacggtttcg
      181 tccgtgttgc agccgatcat cagcacatct aggttttgtc cgggtgtgac cgaaaggtaa
      241 gatggagagc cttgtccctg gtttcaacga gaaaacacac gtccaactca gtttgcctgt
      301 tttacaggtt cgcgacgtgc tcgtacgtgg ctttggagac tccgttgagg aggtcttatc
      361 agaggcacgt caacatctta aagatggcac ttgtggctta gtagaagttg aaaaaggcgt
      421 tttgcctcaa cttgaacagc cctatgtgtt catcaaacgt tcggatgctc gaactgcacc
      481 tcatgtggtt gagctggtag cagaactcga aggcattcag tacggtcgta gtggtgagac
      541 acttggtgtc cttgtccctt atgtgggcga aataccagtg gcttaccgca aggttcttct
      601 tcgtaagaac ggtaataaag gagctggtgg ccataggtac ggcgccgatc taaagtcatt
      661 tgacttaggc gacgagcttg gcactgatcc ttatgaagat tttcaagaaa actggaacac
      721 taaacatagc agtggtgtta cccgtgaact catgcgtgag cttaacggag gggcatacac
      781 tcgctatgtc gataacaact tctgtggccc tgatggctac cctcttgagt gcattaaaga
      841 ccttctagca cgtgctggta aagcttcatg cactttgtcc gaacaactgg actttattga
      901 cactaagagg ggtgtatact gctgccgtga acatgagcat gaaattgctt ggtacacgga
      961 acgttctgaa aagagctatg aattgcagac accttttgaa attaaattgg caaagaaatt
     1021 tgacaccttc aatggggaat gtccaaattt tgtatttccc ttaaattcca taatcaagac
     1081 tattcaacca agggttgaaa agaaaaagct tgatggcttt atgggtagaa ttcgatctgt
     1141 ctatccagtt gcgtcaccaa atgaatgcaa ccaaatgtgc ctttcaactc tcatgaagtg
     1201 tgatcattgt ggtgaaactt catggcagac gggcgatttt gttaaagcca cttgcgaatt
     1261 ttgtggcact gagaatttga ctaaagaagg tgccactact tgtggttact taccccaaaa
     1321 tgctgttgtt aaaatttatt gtccagcatg tcacaattca gaagtaggac ctgagcatag
     1381 tcttgccgaa tatcataatg aatctggctt gaaaaccatt cttcgtaagg gtggtcgcac
     1441 tattgccttt ggaggctgtg tgttctctta tgttggttgc cataacaagt gtgcctattg
     1501 ggttccacgt gctagcgcta acataggttg taaccataca ggtgttgttg gagaaggttc
     1561 cgaaggtctt aatgacaacc ttcttgaaat actccaaaaa gagaaagtca acatcaatat
     1621 tgttggtgac tttaaactta atgaagagat cgccattatt ttggcatctt tttctgcttc
     1681 cacaagtgct tttgtggaaa ctgtgaaagg tttggattat aaagcattca aacaaattgt
     1741 tgaatcctgt ggtaatttta aagttacaaa aggaaaagct aaaaaaggtg cctggaatat
     1801 tggtgaacag aaatcaatac tgagtcctct ttatgcattt gcatcagagg ctgctcgtgt
     1861 tgtacgatca attttctccc gcactcttga aactgctcaa aattctgtgc gtgttttaca
     1921 gaaggccgct ataacaatac tagatggaat ttcacagtat tcactgagac tcattgatgc
     1981 tatgatgttc acatctgatt tggctactaa caatctagtt gtaatggcct acattacagg
     2041 tggtgttgtt cagttgactt cgcagtggct aactaacatc tttggcactg tttatgaaaa
     2101 actcaaaccc gtccttgatt ggcttgaaga gaagtttaag gaaggtgtag agtttcttag
     2161 agacggttgg gaaattgtta aatttatctc aacctgtgct tgtgaaattg tcggtggaca
     2221 aattgtcacc tgtgcaaagg aaattaagga gagtgttcag acattcttta agcttgtaaa
     2281 taaatttttg gctttgtgtg ctgactctat cattattggt ggagctaaac ttaaagcctt
     2341 gaatttaggt gaaacatttg tcacgcactc aaagggattg tacagaaagt gtgttaaatc
     2401 cagagaagaa actggcctac tcatgcctct aaaagcccca aaagaaatta tcttcttaga
     2461 gggagaaaca cttcccacag aagtgttaac agaggaagtt gtcttgaaaa ctggtgattt
     2521 acaaccatta gaacaaccta ctagtgaagc tgttgaagct ccattggttg gtacaccagt
数据集编号
序列分析