LOCUS C_AAB30403 7090 aa linear VRL 11-MAY-2023 DEFINITION ORF1ab polyprotein [Severe acute respiratory syndrome coronavirus 2]. ACCESSION C_AAB30403 VERSION C_AAB30403.1 KEYWORDS . SOURCE Severe acute respiratory syndrome coronavirus 2 ORGANISM Severe acute respiratory syndrome coronavirus 2 Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus; Severe acute respiratory syndrome-related coronavirus. DBSOURCE accession C_AA014303.1 REFERENCE 1 (residues 1 to 7090) AUTHORS Zhang,W. TITLE Direct Submission JOURNAL Submitted (11-MAY-2023) Microbe lab, Shanghai Municipal Center for Disease Control & Prevention, west zhongshan road 1380, Shanghai 200336, China COMMENT ##Genome-Assembly-Data-START## Assembly Method :: Consensus sequence method v. 940-000133-00 Sequencing Technology :: MGISEQ-200 ##Genome-Assembly-Data-END## Method: conceptual translation. FEATURES Location/Qualifiers source 1..7090 /organism="Severe acute respiratory syndrome coronavirus 2" /isolate="SARS-CoV-2/human/CHN/SH-XG2305-3675/2023" /isolation_source="Nasopharyngeal swab" /host="Homo sapiens; Host_age: 37; Host_sex: Female" /country="China:Shanghai" /collection_date="2023-05-01" /note="Passage_details/history: Original" Protein 1..7090 /product="ORF1ab polyprotein" mat_peptide 1..177 /product="leader protein" mat_peptide 178..815 /product="nsp2" mat_peptide 816..2760 /product="nsp3" mat_peptide 2761..3260 /product="nsp4" mat_peptide 3261..3566 /product="3C-like proteinase" mat_peptide 3567..3853 /product="nsp6" mat_peptide 3854..3936 /product="nsp7" mat_peptide 3937..4134 /product="nsp8" mat_peptide 4135..4247 /product="nsp9" mat_peptide 4248..4386 /product="nsp10" mat_peptide 4387..5318 /product="RNA-dependent RNA polymerase" mat_peptide 5319..5919 /product="helicase" mat_peptide 5920..6446 /product="3'-to-5' exonuclease" mat_peptide 6447..6792 /product="endoRNAse" mat_peptide 6793..7090 /product="2'-O-ribose methyltransferase" CDS 1..7090 /gene="ORF1ab" /coded_by="join(C_AA014303.1:242..13426, C_AA014303.1:13426..21513)" /ribosomal_slippage ORIGIN 1 meslvpgfne kthvqlslpv lqvrdvlvrg fgdsveevls earqhlrdgt cglvevekgv 61 lpqleqpyvf ikrsdartap hghvmvelva elegiqygrs getlgvlvph vgeipvayrk 121 vllrkngnkg agghrygadl dlgdelgtdp yedfqenwnt khssgvtrel mrelnggayt 181 ryvdnnfcgp dgyplecikd llaragkasc tlseqldfid tkrgvyccre heheiawyte 241 rseksyelqt pfeiklakkf dtfngecpnf vfplnsiikt iqprvekkkl dgfmgrirsv 301 ypvaspnecn qmclstlmkc dhcgetswqt gdfvkatcef cgtenltkeg attcgylpqn 361 avvkiycpac hnsevgpehs laeyhnesgl ktilrkggrt iafggcvfsy vgchnkcayw 421 vprasanigc nhigvvgegs eglndnllei lqkekvnini vgdfklneei aiilasfsas 481 tsafvetvkg ldykafkqiv escgnfkvtk gkakkgawni geqksilspl yafaseaarv 541 vrsifsrtle taqnsvrvlq kaaitildgi sqyslrlida mmftsdlatn nlvvmayitg 601 gvvqltsqwl tnifgtvyek lkpvldwlee kfkegveflr dgweivkfis tcaceivggq 661 ivtcakeike svqtffklvn kflalcadsi iiggaklkal nlgetfvths kglyrkcvks 721 reetgllmpl kapkeiifle getlptevlt eevvlktgdl qpleqptsea veaplvgtpv 781 cinglmllei kdtekycala pnmmvtnntf tlkggaptkv tfgddtviev qgyksvniif 841 elderidkvl nekcsaytve lgtevnefac vvadaviktl qpvselltpl gidldewsma 901 tyylfdesge fklashmycs fyppdedeee gdceeeefep stqyeygted dyqgkplefg 961 atsaalqpee eqeedwlddd sqqtvgqqdg sednqtttiq tivevqpqle meltpvvqti 1021 evnsfsgylk ltdnvyikna diveeakkvk ptvvvnaanv ylkhgggvag alnkatnnam 1081 qvesddyiat ngplkvggsc vlsghnlakh clhvvgpnvn kgediqllks ayenfnqhev 1141 llapllsagi fgadpihslr vcvdtvrtnv ylavfdknly dklvssflem ksekqveqki 1201 aeipkeevkp fiteskpsve qrkqddkkik acveevtttl eetkfltenl llyidingnl 1261 hpdsatlvsd iditflkkda pyivgdvvqe gvltavvipt kkasgtteml akalrkvptd 1321 nyittypgqg lngytveeak tvlkkcksaf yilpsiisne kqeilgtvsw nlremlahae 1381 etrklmpvcv etkaivstiq rkykgikiqe gvvdygarfy fytskttvas lintlndlne 1441 tlvtmplgyv thglnleeaa rymrslkvpa tvsvsspdav tayngyltss sktpeehfie 1501 tislagsykd wsysgqstql gieflkrgdk svyytsnptt fhldgevitf dnlktllslr 1561 evrtikvftt vdninlhtqv vdmsmtygqq fgptyldgad vtkikphnsh egktfyvlpn 1621 ddtlrveafe yyhttdpsfl grymsalnht kkwkypqvng ltsikwadnn cylatalltl 1681 qqielkfnpp alqdayyrar ageaanfcal ilaycnktvg elgdvretms ylfqhanlds 1741 ckrvlnvvck tcgqqqttlk gveavmymgt lsyeqfkkgv qipctcgkqa tkylvqqesp 1801 fvmmsappaq yelkhgtftc aseytgnyqc ghykhitske tlycidgall tksseykgpi 1861 tdvfykensy tttikpvtyk ldgvvcteid pkldnyykkd nsyfteqpid lvpnqpypna 1921 sfdnfkfvcd nikfaddlnq ltgykkpasr elkvtffpdl ngdvvaidyk hytpsfkkga 1981 kllhkpivwh vnnatnkaty kpntwcircl wstkpvetsn sfdvlkseda qgmdnlaced 2041 lkpvseevve nptiqkdvle cnvkttevvg diilkpanns lkiteevght dlmaayvdns 2101 sltikkpnel srvlglktla thglaavnsv pwdtianyak pflnkvvstt tnivtrclnr 2161 vctnympyff tlllqlctft rstnsrikas mpttiakntv ksvgkfclea sfnylkspnf 2221 skliniiiwf lllsvclgsl iystaalgvl msnlgmpsyc tgyregylns tnvtiatyct 2281 gsipcsvcls gldsldtyps letiqitiss fkwdltafgl vaewflayil ftrffyvlgl 2341 aaimqlffsy favhfisnsw lmwliinlvq mapisamvrm yiffasfyyv wksyvhvvdg 2401 cnsstcmmcy krnratrvec ttivngvrrs fyvyanggkg fcklhnwncv ncdtfcagst 2461 fisdevardl slqfkrpinp tdqssyivds vtvkngsihl yfdkagqkty erhslshfvn 2521 ldnlranntk gslpinvivf dgkskceess aksasvyysq lmcqpillld qalvsdvgds 2581 aevavkmfda yvntfsstfn vpmeklktlv ataeaelakn vsldnvlstf isaarqgfvd 2641 sdvetkdvve clklshqsdi evtgdscnny mltynkvenm tprdlgacid csarhinaqv 2701 akshnialiw nvkdfmslse qlrkqirsaa kknnlpfklt cattrqvvnv vttkialkgg 2761 kivnnwlkql ikvtlvflfv aaifylitpv hvmskhtdfs seiigykaid ggvtrdiast 2821 dtcfankhad fdtwfsqrgg sytndkacpl iaavitrevg fvvpglpgti lrttngdflh 2881 flprvfsavg nicytpskli eytdfatsac vlaaectifk dasgkpvpyc ydtnvlegsv 2941 ayeslrpdtr yvlmdgsiiq fpntylegsv rvvttfdsey crhgtcerse agvcvstsgr 3001 wvlnndyyrs lpgvfcgvda vnlftnmftp liqpigaldi sasivaggiv aivvtclayy 3061 fmrfrrafge yshvvafntl lflmsfivlc ltpvysflpg vysviylylt fyltndvsfl 3121 ahiqwmvmft plvpfwitia yiicistkhf ywffsnylkr rvvfngvsfs tfeeaalctf 3181 llnkemylkl rsdvllpftq ynrylalynk ykyfsgamdt tsyreaacch lakalndfsn 3241 sgsdvlyqpp qisitsavlq sgfrkmafps gkvegcmvqv tcgtttlngl wlddvvycpr 3301 hvictsedml npnyedllir ksnhnflvqa gnvqlrvigh smqncvlklk vdtanpktpk 3361 ykfvriqpgq tfsvlacyng spsgvyqcam rhnftikgsf lngscgsvgf nidydcvsfc 3421 ymhhmelptg vhagtdlegn fygpfvdrqt aqaagtdtti tvnvlawlya avingdrwfl 3481 nrftttlndf nlvamkynye pltqdhvdil gplsaqtgia vldmcaslke llqngmngrt 3541 ilgsallede ftpfdvvrqc sgvtfqsavk rtikgthqwl lltiltsllv lvqstqwslf 3601 fflyenaflp famgiiamsa fammfvkhkh aflclfllps latvayfnmv ympaswvmri 3661 mtwldmvdts lklkdcvmya savvllilmt artvyddgar rvwtlmnvlt lvykvyygna 3721 ldqaismwal iisvtsnysg vvttvmflar givfmcveyc piffitgntl qcimlvycfl 3781 gyfctcyfgl fcllnryfrl tlgvydylvs tqefrymnsq glfppknsid afklnikllg 3841 vggkpcikva tvqskmsdvk ctsvvllsvl qqlrvesssk lwaqcvqlhn dillakdtte 3901 afekmvslls vllsmqgavd inklceemld nratlqaias efsslpsyaa fataqeayeq 3961 avangdsevv lkklkkslnv aksefdrdaa mqrklekmad qamtqmykqa rsedkrakvt 4021 samqtmlftm lrkldndaln niinnardgc vplniipltt aaklmvvipd yntykntcdg 4081 ttftyasalw eiqqvvdads kivqlseism dnspnlawpl ivtalransa vklqnnelsp 4141 valrqmscaa gttqtactdd nalayynttk ggrfvlalls dlqdlkwarf pksdgtgtiy 4201 teleppcrfv tdtpkgpkvk ylyfikglnn lnrgmvlgsl aatvrlqagn atevpanstv 4261 lsfcafavda akaykdylas ggqpitncvk mlcthtgtgq aitvtpeanm dqesfggasc 4321 clycrchidh pnpkgfcdlk gkyvqipttc andpvgftlk ntvctvcgmw kgygcscdql 4381 repmlqsada qsflnrvcgv saarltpcgt gtstdvvyra fdiyndkvag fakflktncc 4441 rfqekdeddn lidsyfvvkr htfsnyqhee tiynllkdcp avakhdffkf ridgdmvphi 4501 srqrltkytm adlvyalrhf degncdtlke ilvtynccdd dyfnkkdwyd fvenpdilrv 4561 yanlgervrq allktvqfcd amrnagivgv ltldnqdlng nwydfgdfiq ttpgsgvpvv 4621 dsyysllmpi ltltraltae shvdtdltkp yikwdllkyd fteerlklfd ryfkywdqty 4681 hpncvncldd rcilhcanfn vlfstvfplt sfgplvrkif vdgvpfvvst gyhfrelgvv 4741 hnqdvnlhss rlsfkellvy aadpamhaas gnllldkrtt cfsvaaltnn vafqtvkpgn 4801 fnkdfydfav skgffkegss velkhfffaq dgnaaisdyd yyrynlptmc dirqllfvve 4861 vvdkyfdcyd ggcinanqvi vnnldksagf pfnkwgkarl yydsmsyedq dalfaytkrn 4921 viptitqmnl kyaisaknra rtvagvsics tmtnrqfhqk llksiaatrg atvvigtskf 4981 yggwhnmlkt vysdvenphl mgwdypkcdr ampnmlrima slvlarkhtt ccslshrfyr 5041 lanecaqvls emvmcgssly vkpggtssgd attayansvf nicqavtanv nallstdgnk 5101 iadkyvrnlq hrlyeclyrn rdvdtdfvne fyaylrkhfs mmilsddavv cfnstyasqg 5161 lvasiknfks vlyyqnnvfm seakcwtetd ltkgphefcs qhtmlvkqgd dyvylpypdp 5221 srilgagcfv ddivktdgtl mierfvslai daypltkhpn qeyadvfhly lqyirklhde 5281 ltghmldmys vmltndntsr ywepefyeam ytphtvlqav gacvlcnsqt slrcgacirr 5341 pflcckccyd hviptshklv lsvnpyvcna pgcdvtdvtq lylggmsyyc kshkppisfp 5401 lcangqvfgl ykntcvgsdn vtdfnaiatc dwtnagdyil antcterlkl faaetlkate 5461 etfklsygia tvrevlsdre lhlswevgkp rpplnrnyvf tgyrvtknsk vqigeytfek 5521 gdygdavvyr gtttyklnvg dyfvltshtv mplsaptlvp qehyvritgl yptlnisdef 5581 ssnvanyqkv gmqkystlqg ppgtgkshfa iglalyypsa rivytacsha avdalcekal 5641 kylpidkcsr iipararvec fdkfkvnstl eqyvfctvna lpettadivv fdeismatny 5701 dlsvvnarlc akhyvyigdp aqlpaprtll tkgtlepeyf nsvcrlmkti gpdmflgtcr 5761 rcpaeivdtv salvydnklk ahkdksaqcf kmfykgvith dvssainrpq igvvrefltr 5821 npawrkavfi spynsqnava skilglptqt vdssqgseyd yviftqttet ahscnvnrfn 5881 vaitrakvgi lcimsdrdly dklqftslei prrnvatlqa envtglfkdc skvitglhpt 5941 qapthlsvdt kfkteglcvd vpgipkdmty rrlismmgfk mnyqvngypn mfitreeair 6001 hvrawigfdv egchatreav gtnlplqlgf stgvnlvavp tgyvdtpnnt dfsrvsakpp 6061 pgdqfkhlip lmykglpwnv vrikivqmls dtlknlsdrv vfvlwahgfe ltsmkyfvki 6121 gpertcclcd rratcfstas ytyacwhhsi gfdyvynpfm idvqqwgftg nlqsnhdlyc 6181 qvhgnahvas cdaimtrcla vhecfvkrvd wtieypiigd elkinaacrk vqhmvvkaal 6241 ladkfpvlhd ignpkaikcv pqadvewkfy daqpcsdkay kieelfysya thsdkftdgv 6301 clfwncnvdr ypansivcrf dtrvlsnlnl pgcdggslyv nkhafhtpaf dksafvnlkq 6361 lpffyysdsp ceshgkqvvs didyvplksa tcitrcnlgg avcrhhaney rlyldaynmm 6421 isagfslwvy kqfdtynlwn tftrlqslen vafnvvnkgh fdgqqgevpv siinntvytk 6481 vdgvdvelfe nkttlpvnva felwakrnik pvpevkilnn lgvdiaantv iwdykrdapa 6541 histigvcsm tdiakkpiet icapltvffd grvdgqvdlf rnarngvlit egsvkglqps 6601 vgpkqaslng vtligeavkt qfnyykkvdg vvqqlpetyf tqsrnlqefk prsqmeidfl 6661 elamdefier yklegyafeh ivygdfshsq lgglhlligl akrfkespfe ledfipmdst 6721 vknyfitdaq tgsskcvcsv idlllddfve iiksqdlsvv skvvkvtidy teisfmlwck 6781 dghvetfypk lqssqawqpg vampnlykmq rmllekcdlq nygdsatlpk gimmnvakyt 6841 qlcqylntlt lavpynmrvi hfgagsdkgv apgtavlrqw lptgtllvds dlndfvsdad 6901 stligdcatv htankwdlii sdmydpktkn vtkendskeg fftyicgfiq qklalggsva 6961 ikitehswna dlyklmghfa wwtafvtnvn assseaflig cnylgkpreq idgyvmhany 7021 ifwrntnpiq lssyslfdms kfplklrgta vmslkegqin dmilsllskg rliirennrv 7081 vissdvlvnn //