LOCUS C_AAB30470 7093 aa linear VRL 11-MAY-2023 DEFINITION ORF1ab polyprotein [Severe acute respiratory syndrome coronavirus 2]. ACCESSION C_AAB30470 VERSION C_AAB30470.1 KEYWORDS . SOURCE Severe acute respiratory syndrome coronavirus 2 ORGANISM Severe acute respiratory syndrome coronavirus 2 Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus; Severe acute respiratory syndrome-related coronavirus. DBSOURCE accession C_AA014309.1 REFERENCE 1 (residues 1 to 7093) AUTHORS Zhang,W. TITLE Direct Submission JOURNAL Submitted (11-MAY-2023) Microbe lab, Shanghai Municipal Center for Disease Control & Prevention, west zhongshan road 1380, Shanghai 200336, China COMMENT ##Genome-Assembly-Data-START## Assembly Method :: Consensus sequence method v. 940-000133-00 Sequencing Technology :: MGISEQ-200 ##Genome-Assembly-Data-END## Method: conceptual translation. FEATURES Location/Qualifiers source 1..7093 /organism="Severe acute respiratory syndrome coronavirus 2" /isolate="SARS-CoV-2/human/CHN/SH-XG2305-3694/2023" /isolation_source="Pharyngeal swab" /host="Homo sapiens; Host_age: 26; Host_sex: Female" /country="China:Shanghai" /collection_date="2023-05-02" /note="Passage_details/history: Original" Protein 1..7093 /product="ORF1ab polyprotein" mat_peptide 1..180 /product="leader protein" mat_peptide 181..818 /product="nsp2" mat_peptide 819..2763 /product="nsp3" mat_peptide 2764..3263 /product="nsp4" mat_peptide 3264..3569 /product="3C-like proteinase" mat_peptide 3570..3856 /product="nsp6" mat_peptide 3857..3939 /product="nsp7" mat_peptide 3940..4137 /product="nsp8" mat_peptide 4138..4250 /product="nsp9" mat_peptide 4251..4389 /product="nsp10" mat_peptide 4390..5321 /product="RNA-dependent RNA polymerase" mat_peptide 5322..5922 /product="helicase" mat_peptide 5923..6449 /product="3'-to-5' exonuclease" mat_peptide 6450..6795 /product="endoRNAse" mat_peptide 6796..7093 /product="2'-O-ribose methyltransferase" CDS 1..7093 /gene="ORF1ab" /coded_by="join(C_AA014309.1:242..13435, C_AA014309.1:13435..21522)" /ribosomal_slippage ORIGIN 1 meslvpgfne kthvqlslpv lqvrdvlvrg fgdsveevls earqhlrdgt cglvevekgv 61 lpqleqpyvf ikrsdartap hghvmvelva elegiqygrs getlgvlvph vgeipvayrk 121 vllrkngnkg agghrygadl ksfdlgdelg tdpyedfqen wntkhssgvt relmrelngg 181 aytryvdnnf cgpdgyplec ikdllaragk asctlseqld fidtkrgvyc creheheiaw 241 yterseksye lqtpfeikla kkfdtfngec pnfvfplnsi iktiqprvek kkldgfmgri 301 rsvypvaspn ecnqmclstl mkcdhcgets wqtgdfvkat cefcgtenlt kegattcgyl 361 pqnavvkiyc pachnsevgp ehslaeyhne sglktilrkg grtiafggcv fsyvgchnkc 421 aywvprasan igcnhtgvvg egseglndnl leilqkekvn inivgdfkln eeiaiilasf 481 sastsafvet vkgldykafk qivescgnfk vtkgkakkga wnigeqksil splyafasea 541 arvvrsifsr tletaqnsvr vlqkaaitil dgisqyslrl idammftsdl atnnlvvmay 601 itggvvqlts qwltnifgtv yeklkpvldw leekfkegve flrdgweivk fistcaceiv 661 ggqivtcake ikesvqtffk lvnkflalca dsiiiggakl kalnlgetfv thskglyrkc 721 vksreetgll mplkapkeii flegetlptk vlteevvlkt gdlqpleqpt seaveaplvg 781 tpvcinglml leikdtekyc alapnmmvtn ntftlkggap tkvtfgddtv ievqgyksvn 841 iifelderid kvlnekcsay tvelgtevne facvvadavi ktlqpvsell tplgidldew 901 smatyylfde sgefklashm ycsfyppded eeegdceeee fepstqyeyg teddyqgkpl 961 efgatsaalq peeeqeedwl dddsqqtvgq qdgsednqtt tiqtivevqp qlemeltpvv 1021 qtievnsfsg ylkltdnvyi knadiveeak kvkptvvvna anvylkhggg vagalnkatn 1081 namqvesddy iatngplkvg gscvlsghnl akhclhvvgp nvnkgediql lksayenfnq 1141 hevllaplls agifgadpih slrvcvdtvr tnvylavfdk nlydklvssf lemksekqve 1201 qkiaeipkee vkpfiteskp sveqrkqddk kikacveevt ttleetkflt enlllyidin 1261 gnlhpdsatl vsdiditflk kyapyivgdv vqegvltavv iptkkasgtt emlakalrkv 1321 ptdnyittyp gqglngytve eaktvlkkck safyilpsii snekqeilgt vswnlremla 1381 haeetrklmp vcvetkaivs tiqrkykgik iqegvvdyga rfyfytsktt vaslintlnd 1441 lnetlvtmpl gyvthglnle eaarymrslk vpatvsvssp davtayngyl tsssktpeeh 1501 fietislags ykdwsysgqs tqlgieflkr gdksvyytsn pttfhldgev itfdnlktll 1561 slrevrtikv fttvdninlh tqvvdmsmty gqqfgptyld gadvtkikph nshegktfyv 1621 lpnddtlrve afeyyhttdp sflgrymsal nhtkkwkypq vngltsikwa dnncylatal 1681 ltlqqielkf nppalqdayy rarageaanf calilaycnk tvgelgdvre tmsylfqhan 1741 ldsckrvlnv vcktcgqqqi tlkgveavmy mgtlsyeqfk kgvqipctcg kqatkylvqq 1801 espfvmmsap paqyelkhgt ftcaseytgn yqcghykhit sketlycidg alltksseyk 1861 gpitdvfyke nsytttikpv tykldgvvct eidpkldnyy kkdnsyfteq pidlvpnqpy 1921 pnasfdnfkf vcdnikfadd lnqltgykkp asrelkvtff pdlngdvvai dykhytpsfk 1981 kgakllhkpi vwhvnnatnk atykpntwci rclwstkpve tsnsfdvlks edaqgmdnla 2041 cedlkpvsee vvenptiqkd vlecnvktte vvgdiilkpa nnslkiteev ghtdlmaayv 2101 dnssltikkp nelsrvlglk tlathglaav nsvpwdtian yakpflnkvv stttnivtrc 2161 lnrvctnymp yfftlllqlc tftrstnsri kasmpttiak ntvksvgkfc leasfnylks 2221 pnfsklinii iwflllsvcl gsliystaal gvlmsnlgmp syctgyregy lnstnvtiat 2281 yctgsipcsv clsgldsldt ypsletiqit issfkwdlta fglvaewfla yilftrffyv 2341 lglaaimqlf fsyfavhfis nswlmwliin lvqmapisam vrmyiffasf yyvwksyvhv 2401 vdgcnsstcm mcykrnratr vecttivngv rrsfyvyang gkgfcklhnw ncvncdtfca 2461 gstfisdeva rdlslqfkrp inptdqssyi vdsvtvkngs ihlyfdkagq ktyerhslsh 2521 fvnldnlran ntkgslpinv ivfdgkskce essaksasvy ysqlmcqpil lldqalvsdv 2581 gdsaevavkm fdayvntfss tfnvpmeklk tlvataeael aknvsldnvl stfisaarqg 2641 fvdsdvetkd vveclklshq sdievtgdsc nnymltynkv enmtprdlga cidcsarhin 2701 aqvakshnia liwnvkdfms lseqlrkqir saakknnlpf kltcattrqv vnvvttkial 2761 kggkivnnwl kqlikvtlvf lfvaaifyli tpvhvmskht dfsseiigyk aidggvtrdi 2821 astdtcfank hadfdtwfsq rggsytndka cpliaavitr evgfvvpglp gtilrttngd 2881 flhflprvfs avgnicytps klieytdfat sacvlaaect ifkdasgkpv pycydtnvle 2941 gsvayeslrp dtryvlmdgs iiqfpntyle gsvrvvttfd seycrhgtce rseagvcvst 3001 sgrwvlnndy yrslpgvfcg vdavnlftnm ftpliqpiga ldisasivag givaivvtcl 3061 ayyfmrfrra fgeyshvvaf ntllflmsfi vlcltpvysf lpgvysviyl yltfyltndv 3121 sflahiqwmv mftplvpfwi tiayiicist khfywffsny lkrrvvfngv sfstfeeaal 3181 ctfllnkemy lklrsdvllp ftqynrylal ynkykyfsga mdttsyreaa cchlakalnd 3241 fsnsgsdvly qppqisitsa vlqsgfrkma fpsgkvegcm vqvtcgtttl nglwlddvvy 3301 cprhvictse dmlnpnyedl lirksnhnfl vqagnvqlrv ighsmqncvl klkvdtanpk 3361 tpkykfvriq pgqtfsvlac yngspsgvyq camrhnftik gsflngscgs vgfnidydcv 3421 sfcymhhmel ptgvhagtdl egnfygpfvd rqtaqaagtd ttitvnvlaw lyaavingdr 3481 wflnrftttl ndfnlvamky nyepltqdhv dilgplsaqt giavldmcas lkellqngmn 3541 grtilgsall edeftpfdvv rqcsgvtfqs avkrtikgth hwllltilts llvlvqstqw 3601 slffflyena flpfamgiia msafammfvk hkhaflclfl lpslatvayf nmvympaswv 3661 mrimtwldmv dtslklkdcv myasavvlli lmtartvydd garrvwtlmn vltlvykvyy 3721 gnaldqaism waliisvtsn ysgvvttvmf largivfmcv eycpiffitg ntlqcimlvy 3781 cflgyfctcy fglfcllnry frltlgvydy lvstqefrym nsqgllppkn sidafklnik 3841 llgvggkpci kvatvqskms dvkctsvvll svlqqlrves ssklwaqcvq lhndillakd 3901 tteafekmvs llsvllsmqg avdinklcee mldnratlqa iasefsslps yaafataqea 3961 yeqavangds evvlkklkks lnvaksefdr daamqrklek madqamtqmy kqarsedkra 4021 kvtsamqtml ftmlrkldnd alnniinnar dgcvplniip lttaaklmvv ipdyntyknt 4081 cdgttftyas alweiqqvvd adskivqlse ismdnspnla wplivtalra nsavklqnne 4141 lspvalrqms caagttqtac tddnalayyn ttkggrfvla llsdlqdlkw arfpksdgtg 4201 tiyteleppc rfvtdtpkgp kvkylyfikg lnnlnrgmvl gslaatvrlq agnatevpan 4261 stvlsfcafa vdaakaykdy lasggqpitn cvkmlcthtg tgqaitvtpe anmdqesfgg 4321 ascclycrch idhpnpkgfc dlkgkyvqip ttcandpvgf tlkntvctvc gmwkgygcsc 4381 dqlrepmlqs adaqsflnrv cgvsaarltp cgtgtstdvv yrafdiyndk vagfakflkt 4441 nccrfqekde ddnlidsyfv vkrhtfsnyq heetiynllk dcpavakhdf fkfridgdmv 4501 phisrqrltk ytmadlvyal rhfdegncdt lkeilvtync cdddyfnkkd wydfvenpdi 4561 lrvyanlger vrqallktvq fcdamrnagi vgvltldnqd lngnwydfgd fiqttpgsgv 4621 pvvdsyysll mpiltltral taeshvdtdl tkpyikwdll kydfteerlk lfdryfkywd 4681 qtyhpncvnc lddrcilhca nfnvlfstvf pltsfgplvr kifvdgvpfv vstgyhfrel 4741 gvvhnqdvnl hssrlsfkel lvyaadpamh aasgnllldk rttcfsvaal tnnvafqtvk 4801 pgnfnkdfyd favskgffke gssvelkhff faqdgnaais dydyyrynlp tmcdirqllf 4861 vvevvdkyfd cydggcinan qvivnnldks agfpfnkwgk arlyydsmsy edqdalfayt 4921 krnviptitq mnlkyaisak nrartvagvs icstmtnrqf hqkllksiaa trgatvvigt 4981 skfyggwhnm lktvysdven phlmgwdypk cdrampnmlr imaslvlark httccslshr 5041 fyrlanecaq vlsemvmcgs slyvkpggts sgdattayan svfnicqavt anvnallstd 5101 gnkiadkyvr nlqhrlyecl yrnrdvdtdf vnefyaylrk hfsmmilsdd avvcfnstya 5161 sqglvasikn fksvlyyqnn vfmseakcwt etdltkgphe fcsqhtmlvk qgddyvylpy 5221 pdpsrilgag cfvddivktd gtlmierfvs laidaypltk hpnqeyadvf hlylqyirkl 5281 hdeltghmld mysvmltndn tsrywepefy eamytphtvl qavgacvlcn sqtslrcgac 5341 irrpflcckc cydhviptsh klvlsvnpyv cnapgcdvtd vtqlylggms yyckshkppi 5401 sfplcangqv fglykntcvg sdnvtdfnai atcdwtnagd yilantcter lklfaaetlk 5461 ateetfklsy giatvrevls drelhlswev gkprpplnrn yvftgyrvtk nskvqigeyt 5521 fekgdygdav vyrgtttykl nvgdyfvlts htvmplsapt lvpqehyvri tglyptlnis 5581 defssnvany qkvgmqkyst lqgppgtgks hfaiglalyy psarivytac shaavdalce 5641 kalkylpidk csriiparar vecfdkfkvn stleqyvfct vnalpettad ivvfdeisma 5701 tnydlsvvna rlcakhyvyi gdpaqlpapr tlltkgtlep eyfnsvcrlm ktigpdmflg 5761 tcrrcpaeiv dtvsalvydn klkahkdksa qcfkmfykgv ithdvssain rpqigvvref 5821 ltrnpawrka vfispynsqn avaskilglp tqtvdssqgs eydyviftqt tetahscnvn 5881 rfnvaitrak vgilcimsdr dlydklqfts leiprrnvat lqaenvtglf kdcskvitgl 5941 hptqapthls vdtkfktegl cvdvpgipkd mtyrrlismm gfkmnyqvng ypnmfitree 6001 airhvrawig fdvegchatr eavgtnlplq lgfstgvnlv avptgyvdtp nntdfsrvsa 6061 kpppgdqfkh liplmykglp wnvvrikivq mlsdtlknls drvvfvlwah gfeltsmkyf 6121 vkigpertcc lcdrratcfs tasdtyacwh hsigfdyvyn pfmidvqqwg ftgnlqsnhd 6181 lycqvhgnah vascdaimtr clavhecfvk rvdwtieypi igdelkinaa crkvqhmvvk 6241 aalladkfpv lhdignpkai kcvpqadvew kfydaqpcsd kaykieelfy syathsdkft 6301 dgvclfwncn vdrypansiv crfdtrvlsn lnlpgcdggs lyvnkhafht pafdksafvn 6361 lkqlpffyys dspceshgkq vvsdidyvpl ksatcitrcn lggavcrhha neyrlylday 6421 nmmisagfsl wvykqfdtyn lwntftrlqs lenvafnvvn kghfdgqqge vpvsiinntv 6481 ytkvdgvdve lfenkttlpv nvafelwakr nikpvpevki lnnlgvdiaa ntviwdykrd 6541 apahistigv csmtdiakkp ieticapltv ffdgrvdgqv dlfrnarngv litegsvkgl 6601 qpsvgpkqas lngvtligea vktqfnyykk vdgvvqqlpe tyftqsrnlq efkprsqmei 6661 dflelamdef ieryklegya fehivygdfs hsqlgglhll iglakrfkes pfeledfipm 6721 dstvknyfit daqtgsskcv csvidllldd fveiiksqdl svvskvvkvt idyteisfml 6781 wckdghvetf ypklqssqaw qpgvampnly kmqrmllekc dlqnygdsat lpkgimmnva 6841 kytqlcqyln tltlavpynm rvihfgagsd kgvapgtavl rqwlptgtll vdsdlndfvs 6901 dadstligdc atvhtankwd liisdmydpk tknvtkends kegfftyicg fiqqklalgg 6961 svaikitehs wnadlyklmg hfawwtafvt nvnassseaf ligcnylgkp reqidgyvmh 7021 anyifwrntn piqlssyslf dmskfplklr gtavmslkeg qindmilsll skgrliiren 7081 nrvvissdvl vnn //