LOCUS NC_005093 11034 bp RNA linear VRL 13-AUG-2018 DEFINITION Hirame rhabdovirus, complete genome. ACCESSION NC_005093 VERSION NC_005093.1 DBLINK BioProject: PRJNA485481 KEYWORDS RefSeq. SOURCE Novirhabdovirus hirame ORGANISM Novirhabdovirus hirame Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Rhabdoviridae; Gammarhabdovirinae; Novirhabdovirus. REFERENCE 1 (bases 1 to 11034) AUTHORS Kim,D.H., Oh,H.K., Eou,J.I., Seo,H.J., Kim,S.K., Oh,M.J., Nam,S.W. and Choi,T.J. TITLE Complete nucleotide sequence of the hirame rhabdovirus, a pathogen of marine fish JOURNAL Virus Res. 107 (1), 1-9 (2005) PUBMED 15567027 REFERENCE 2 (bases 1 to 11034) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (13-SEP-2003) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (bases 1 to 11034) AUTHORS Oh,H.K., Eou,J.-I., Kim,D.-H. and Choi,T.-J. TITLE Direct Submission JOURNAL Submitted (22-AUG-2002) Microbiology, Pukyong National University, 599-1 Daeyeon 3-Dong, Nam-gu, Busan 608-737, Korea REMARK Nucleotide and amino acid sequences updated by submitter REFERENCE 4 (bases 1 to 11034) AUTHORS Oh,H.K. and Choi,T.J. TITLE Direct Submission JOURNAL Submitted (05-NOV-1998) Microbiology, Pukyong National University, 599-1 Daeyeon-3 dong, Nam-Gu, Pusan 608-737, Korea COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to AF104985. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..11034 /organism="Novirhabdovirus hirame" /mol_type="genomic RNA" /strain="CA 9703" /isolation_source="rainbow trout gonad (RTG-2) cell line" /db_xref="taxon:1980915" misc_feature 1..51 /note="3' untranslated region of viral genomic RNA; codes for putative (+) leader RNA transcript; putative" regulatory 52..60 /regulatory_class="other" /note="signal sequence for transcriptional termination or polyadenylation" gene 167..1345 /gene="N" /locus_tag="HIRRVgp1" /db_xref="GeneID:2559538" CDS 167..1345 /gene="N" /locus_tag="HIRRVgp1" /codon_start=1 /product="nucleocapsid protein" /protein_id="NP_919030.1" /db_xref="GeneID:2559538" /translation="MANLKEEFAGLRGVKGGALEDSGTEYDPTKINLTLYGTDKLYTLA IIKRAVSQVGGSQTNKALGILCAFVTSENNPDMTDAAVKLLVDMRFKVDVVPVDDRLGD NLDDPNSKLAEVLTEENMVDLVKGLLFTCALMVKYDVDKMATYCQQKLERLANSQGLNE LTLISTSRAVLARIGAAVRPGQKLTKAIYGIILINLMDPATAARAKALCAMRLSGTGMT MVGLFNQASKNLGAPPADLLEDLCMKSIIDSARRIVKLMRIVADVEDMTAKYAIMMSRM LGDGYFKSYGINENSRITCILMNINEQYDEGTTGGLAGVRVSPPFRKLATEIARLLVKK YDGNGSAGPGASDLVRQAEQAAQETEGEDDKYDEEGEEDGGEGEGGEDEEYY" misc_feature 257..1081 /gene="N" /locus_tag="HIRRVgp1" /note="Rhabdovirus nucleoprotein; Region: Rhabdo_ncap_2; pfam03216" /db_xref="CDD:397361" regulatory 1392..1404 /regulatory_class="other" /note="signal sequence for transcriptional termination or polyadenylation" gene 1445..2128 /gene="M1" /locus_tag="HIRRVgp2" /db_xref="GeneID:2559535" CDS 1445..2128 /gene="M1" /locus_tag="HIRRVgp2" /codon_start=1 /product="matrix protein 1" /protein_id="NP_919031.1" /db_xref="GeneID:2559535" /translation="MSDNEGEQFFDIPKNALDRVEARTMCPREDGKVVRKQAPLKEEPR LEAEQKRSPKKQEKPRGMLPLEQLVLKYVVVVCSLDALREFGGLIAQIRQSHQADMTRH LEAVATEHRANLQALTKSQQEHEKVSKEILSAVISIRSNLNENSSPRHKPLDLDQVNAE RALGFGVGYRTALNVFGKLRGITPEEAGSQEVKNMAIREAEEDEYEGSRSFFKKVLDMV KKTMR" misc_feature 1445..2125 /gene="M1" /locus_tag="HIRRVgp2" /note="Rhabdovirus M1 matrix protein (M1 polymerase-associated protein); Region: Rhabdo_M1; pfam03342" /db_xref="CDD:281353" gene 2234..2815 /gene="M2" /locus_tag="HIRRVgp3" /db_xref="GeneID:2559537" CDS 2234..2815 /gene="M2" /locus_tag="HIRRVgp3" /codon_start=1 /product="matrix protein 2" /protein_id="NP_919032.1" /db_xref="GeneID:2559537" /translation="MSLFKRTKKTILIPPPHLLSGDEDRVTVLNAEGEIKISGKRPTTL DEKIYYSMSLAAAILGGNLHPSFQSLTYLFQQEMEFGSTIEKVNFGSRKPAPLTPIRWQ KPEKCSFRPQPLDKKIPPQIYTVSVEGATITFSGRFLFSASHVGCDDNRVKLAGLDGFI TSPNYQRVKDYYAQETVLALSFEIPTKKGK" misc_feature 2255..2758 /gene="M2" /locus_tag="HIRRVgp3" /note="Rhabdovirus matrix protein; Region: Rhabdo_matrix; pfam03397" /db_xref="CDD:281400" gene 2924..4450 /gene="G" /locus_tag="HIRRVgp4" /db_xref="GeneID:2559534" CDS 2924..4450 /gene="G" /locus_tag="HIRRVgp4" /codon_start=1 /product="glycoprotein" /protein_id="NP_919033.1" /db_xref="GeneID:2559534" /translation="MDPRIMYYTVLLTTAARVYGQTIKPGVDSVSDQPTWANPLFTYPV DCPAAKLSKVSPSQLRCPRIFDDENRGLVAYPAVIRSLSVGNNLGDIHTQGEYVHKVLY RTTCSTGFFGGQTIEKALVEMKLAPREVGVYDTTTASALYFPAPRCQWYTDNVHNDLTF YYTTAKSVLRDPYTLGFLDSDFIEGKCSKSPCQTHWSNVVWKGDSGVAACDTGSEIKGH IFVDKTSHHVVKATSYGHHPWGLHRACMITFCGKPWIRTDLGDLIAIEYNGGATLLAFP ACKDTTVGMRGSLDDFAYLDDLVKSSESREECLEAHAEIIATNSVTPYLLSKFRSPHPG INDVYAMHDGSIYHGKCMTVAIDEVSKDRRTYRAHQTSAFVAWGHPFGDEWGGFHGLHG NDTPVIPDLEKYVAQYKVSMMDKMDIRPVPHPSVQILYNDTDTADITIRKIDSFDLQSL NWSFWPSLSALGGVPILLALVFFLYCCMNRRPSMPAAPQEIPMYHLASRG" misc_feature 3035..4300 /gene="G" /locus_tag="HIRRVgp4" /note="Rhabdovirus spike glycoprotein; Region: Rhabdo_glycop; pfam00974" /db_xref="CDD:425969" gene 4528..4863 /gene="NV" /locus_tag="HIRRVgp5" /db_xref="GeneID:2559536" CDS 4528..4863 /gene="NV" /locus_tag="HIRRVgp5" /codon_start=1 /product="non-viral protein" /protein_id="NP_919034.1" /db_xref="GeneID:2559536" /translation="MNSKTPSTDIAALKDLLRYKVTVARHGFLFDDGKIVWSEDGDEAW NRLLVVVGALRSSNRMSQALFMDMSITKGDGYLLFSDLQGTNNLQYRTPKFRQYLFPVD EFLPLPR" misc_feature 4528..4860 /gene="NV" /locus_tag="HIRRVgp5" /note="Rhabdovirus Non-virion protein; Region: Rhabdo_NV; pfam02484" /db_xref="CDD:280620" gene 4947..10907 /gene="L" /locus_tag="HIRRVgp6" /db_xref="GeneID:2559539" CDS 4947..10907 /gene="L" /locus_tag="HIRRVgp6" /codon_start=1 /product="RNA polymerase" /protein_id="NP_919035.1" /db_xref="GeneID:2559539" /translation="MDFFDLDIEIKQERLPAECSLNSPLNISLSSQLTDRMTPQNENIR RQRERIRTHTKTHSRIKHLSKLDNDSTRLHARLTEDLIKLQHLEVDSPVFDNWALLTSY YAALDYTLPERASFDWGQAAPYWNLYTQLRTILLQSQKIRKKDRGVREIYSCGPLRLEF VEGTVLYFTDKQSGGEFTKSGELPSITPYADFLAWVKIISQRAQAVLMAVILRVTDKGL SPLPESLLSVYQTVDDILKRAGQPAIDLLKLWEPLVITKLGELLGDRFGLEEDFRLTIR GEATRLAKKLAITNGLNRLMTVLDSQTEAQPLFQFFGLFKHFAYPRVFSRDTIQAIQEV SDRPSSISAAEFLHDQCEIRKEFYIRYLKAYHRAPGLDLSALSPSSFLRESLEHGKIPN EKSPHYSNKEWYFIKFTKSIEWPISDTLSTFLSDKAITRDRAAWIEEGHSGRDMSEKRL LLKFIKENFSSVAEIVAAADAIYNNEGDRLIALKVKEMELKIKGRGFGLMTFMPRLLQV LRESIAKKTSKLFPEITMTSSDLDMKKRKFMLSKRSDDRRGFIHINKSLDINKFCTSQR QFNSSAVFSSLDEMMGTFPLFSRVHEIFEKTWIVDGSASDPPDLSHFTRILEECRLHGI EAPHVWADGVFSGLKGGIEGLCQYVWTICLLLRVERVMQKTKLTHYILAQGDNVIITII VPVEIHRDGIISDQESRRLLTLSRNIDLSLESELEKSGLTLKIEETLTSENISIYGKDL HCPQHLTLALKKAASAAIISSEQYQDIPTFLSGLGTSLESLSECVNSKTGAHLFGVLMG VAGWKDLATHQTWRGWRYPYHKAPLSGRVRASDMKIGKGEAVELTIPVMSPRQQGKETL RELLANSLLGSALGMLAFPTPIDLEKRGVGDYITHRLAIARKALLSEKLDPHIEKRVRS ACNLPLSSRVDLSKLFDSPFSLNLATEEDATAVIKRQAKKTLRLQEIGNDKLRAQIGNM DKGIAALDADLAGAETINPRLNHMIRDITDEKESEMFVTKFASARTMRTLAMGDSSEVP IVVLLEKKSQQKELYTIWRARRPHATMWKCSTVLAKGLRDISWGKTIVGVTSPSPIEAM ETTHIDPTDWEDSRSRETLSINYYLSRAGIDEQTAKLTRGSLVPYYGTQTKPLIAKAYL ELKGNPRTNKALLLLSVRESLVKTGSNLDELIMQLCSHALDIDAASLPALRAQEEATAG EGLRGGIKESMSPVGPDNFYTNITHKVFNRKWVTPYHVNIADFIIQGLIETRKHLILNE KMDGLLPLSSVKCTACFRKKEREFFDIPEGPTWKNDSTTSDPAYTYFTTWCDLPRVSTL PTMDQQSATRLLGRGLSLNRPTAGEIITKFYSMSMESQRLLHPVDLLLGYGEGVVFGYI RSQHIHHGALFQTKRETLTNKLRKFILDTKTQHAKQIGYLFQDEDSLHELMAQGLCPYV PRSIPLTITELTNACAITTIRATEVILSAGSRVALMPVQAIDETDVDNSRLAANTMQTI LGDSRPMNPVYLDCDLTTNMTAWESSIELDVLKSENFHIDGLLMDLTARELPISDTPWK QRDWTCSNDPRIIAKGIKTKSLFIHQGVAEALNMTPDLLVVIGGGLGGCAVPYLQEWAD VPLIFATLFDERERISEDGDLVVPPEILVRGMAPRMIERELLEAELCDVTNDGNRRLLT RLVKKNRGKGTVVLIDEIENRGAPESLLQSSLQDLVRRLDKVCTLTSIHTVRESTVEQF AQRTNSIKRDRKTVTLHWNRYNRRDQFEALVIVKGEETRSDYHVSTATAAQAFRKIDEQ LEVEGRLSATRWSLPTLPAREKEILFGYVSSVFLKTNLVLSADDMDRETLLETIEDTAP GLISWKEKLEHRDHAFRSDIDEKGITQDKVFNLICLAWVITGLRYGIWETDAQSIITKT VYITRGPKLCPLGEKPKRVFASFKLQSDKRVEDAKGFLSALLHLEGFFPLGRQ" misc_feature 4998..8147 /gene="L" /locus_tag="HIRRVgp6" /note="Mononegavirales RNA dependent RNA polymerase; Region: Mononeg_RNA_pol; pfam00946" /db_xref="CDD:395756" misc_feature 8178..8864 /gene="L" /locus_tag="HIRRVgp6" /note="Mononegavirales mRNA-capping region V; Region: Mononeg_mRNAcap; pfam14318" /db_xref="CDD:405070" ORIGIN 1 gtatcaaaaa gataacatac gccaagacta ggagagatgg gggcagggga cagaaaaaaa 61 tggcacttca gttgtacact gataacgtgt tatagacact agaaaccaag tctaagtgat 121 atattctgtt tgcgatctct acaacaagat taaaccagaa atcaatatgg cgaaccttaa 181 ggaagaattt gcaggactcc gaggagtgaa gggaggagcc ctcgaagact ctggcacgga 241 gtatgatccc accaagatca acctgacgct ctacgggaca gacaagctct ataccctggc 301 gatcatcaag agggcagtca gtcaggtcgg agggtcccaa accaacaaag cactaggaat 361 cctttgtgct tttgtcacgt cagagaacaa ccctgacatg acagatgcag cagtcaagct 421 cctggtggac atgaggttca aggtggacgt ggtgcccgtg gacgacaggc tcggtgacaa 481 tctggatgac cccaactcaa agctggcgga ggtcctgacg gaagagaaca tggtggacct 541 ggtgaaaggc cttctgttca cttgtgccct gatggtcaag tacgatgtgg acaagatggc 601 cacatactgc cagcagaagc tggagcgact ggccaacagt cagggactca acgagctgac 661 cctgataagc acgagtaggg cagttctggc tcggattggg gcagcggtaa gaccggggca 721 gaagttaacc aaggccatct acgggatcat tcttatcaac ctgatggatc ccgccactgc 781 tgccagggca aaggcccttt gtgccatgag gctgagcgga accggaatga ccatggtggg 841 tctattcaat caggcctcta agaaccttgg agctccacct gcagatctgc tggaagatct 901 ctgcatgaag tccatcatcg actctgccag gaggattgtc aagctgatga ggatcgttgc 961 agacgtcgag gacatgaccg caaagtatgc catcatgatg agcaggatgc ttggggatgg 1021 gtacttcaag tcctacggga tcaatgagaa ctcacggatc acctgtatct tgatgaacat 1081 caacgagcag tacgatgagg ggacaaccgg aggactggca ggagtcaggg tttcaccccc 1141 cttccgaaag ctggcaaccg agattgctcg ccttctggtc aaaaagtatg acgggaacgg 1201 atctgccggg ccaggtgcct cagatcttgt ccgccaggcc gagcaggcag cgcaagagac 1261 cgagggcgag gatgataagt acgatgagga gggcgaggaa gacggagggg agggagaggg 1321 gggagaggac gaagagtact actgagaccc ggcatctatg tcgccttggg ttgcctccca 1381 acattactat tcttagatag aaaaaaatgg cacgtttgtg taaaacaaca atcaacaaat 1441 cgcaatgtct gataacgaag gagaacagtt ctttgatatt cccaagaatg ctctggacag 1501 agttgaggca cggacgatgt gtcccaggga ggatggaaag gttgtccgga aacaagcgcc 1561 tctaaaagag gaaccaagac tggaggcaga gcagaagcgg tctccaaaga agcaggagaa 1621 accccgggga atgctccctc tggaacaact tgttctgaag tatgtggttg tggtctgctc 1681 ccttgatgcg ctccgagagt tcggaggact aattgcccag atcaggcagt ctcatcaggc 1741 cgatatgact cgtcatctgg aggcagtggc aacagagcac cgggccaatc tccaggcgct 1801 caccaagtct cagcaggagc acgagaaagt ctccaaagag atcctctcgg cagtcatctc 1861 catccggtcc aacctcaacg agaactccag tccccgacac aaacccctgg acctggacca 1921 ggtcaatgcg gagagagccc tcggatttgg agtcgggtac cggaccgcct tgaacgtctt 1981 tggcaaacta cggggaatca caccagaaga ggcaggctcg caagaagtca agaacatggc 2041 aatcagagag gcagaagaag atgagtatga gggaagcaga agcttcttca agaaggtcct 2101 cgatatggtc aagaagacca tgaggtagag caagccaaca tcccactcgc caactcccac 2161 tcccctagat agaaaaaaat ggcacgttag tgtactgttt taacagaaac caaaaccaaa 2221 gtcgaaagaa accatgtctc tcttcaagcg aaccaagaag accattctga tccctccccc 2281 tcatctgctt agcggagacg aggaccgggt gacagttcta aatgcagagg gcgagatcaa 2341 gatctcaggg aagcgaccaa ccaccctcga tgagaagatc tactactcca tgagtctggc 2401 cgccgccatt ctgggaggga atcttcatcc atctttccaa tctctgacct atctatttca 2461 gcaggagatg gaattcggga gcaccataga aaaggtcaac tttgggtccc ggaaaccggc 2521 ccccctgaca cctatcaggt ggcaaaagcc cgagaagtgt tcattcaggc ctcaacccct 2581 ggacaaaaag atccctcctc agatttacac tgtcagtgtg gagggggcga ccatcacctt 2641 ctccgggagg tttctctttt cggccagtca tgtggggtgt gacgacaacc gggtcaagct 2701 ggctggcctg gatggcttca tcacctcacc caactaccaa agagtgaaag actattatgc 2761 acaggaaact gtcctggcgt tgtccttcga aattccaacc aaaaaaggaa aatagtcaca 2821 atgactcccc atttaaatcg accctctcaa atctatcaac tcacatcaga tagaaaaaaa 2881 tggcacattt gtgtgttttc ataacaaaca atcgacactc gtcatggacc ctcgaataat 2941 gtattacact gttctcctca cgacagctgc cagagtctat ggtcaaacca tcaagcctgg 3001 agttgacagc gtatccgatc aacccacctg ggcgaatccc ctgtttacat accctgtgga 3061 ctgtcctgcg gctaagctat ccaaggtgag tccctcacag ttgaggtgcc cacgcatatt 3121 tgatgatgaa aaccgaggac tcgttgccta ccctgctgtc atcagatccc tatcggtagg 3181 gaacaatctt ggggacattc atactcaggg ggaatacgtc cacaaggtcc tttaccgaac 3241 cacatgttca acagggttct ttgggggcca aaccatagag aaggccctag tagagatgaa 3301 actggccccc agggaggtgg gagtgtatga caccacgaca gcctcagcac tgtacttccc 3361 agctccaagg tgccaatggt acacggacaa tgtacataac gacctgacat tctactatac 3421 gaccgccaag agtgtcctta gagatcctta caccctggga ttccttgatt ctgattttat 3481 tgaagggaag tgctccaagt cgccgtgtca gacccattgg tcaaatgtgg tgtggaaggg 3541 agactcggga gttgccgcct gtgacacggg gtctgagata aagggtcaca tatttgtgga 3601 caagacctcc caccatgtcg tcaaggcaac gagctatgga caccacccat ggggacttca 3661 tcgagcttgc atgattacct tctgtggaaa accatggatc aggacagacc taggggacct 3721 catcgcaatc gaatacaatg gcggggcgac ccttctcgca ttccctgctt gcaaggacac 3781 cacggttgga atgagaggga gtcttgacga ctttgcctac ttggatgatc tggtgaagtc 3841 atctgaaagt cgggaggaat gtctagaggc acatgcggag atcatcgcta ccaatagtgt 3901 gactccttac ctgctatcca aattcagatc tccccaccca ggaataaacg atgtctacgc 3961 catgcatgac gggtccatat accacggaaa gtgcatgacc gttgccattg atgaggtttc 4021 caaagataga cgaacttatc gtgcccacca gacctcagct ttcgtagcat gggggcatcc 4081 cttcggtgat gaatggggcg ggtttcacgg tcttcatggc aacgatactc ctgtgattcc 4141 ggatcttgag aaatacgtcg ctcagtacaa ggtgagcatg atggacaaga tggacattcg 4201 ccccgttccg catcctagtg tccagatact ctacaacgac acagacaccg cagacatcac 4261 aatcaggaag atagactcgt ttgatctgca atcactcaac tggagcttct ggccatcatt 4321 gtcagcactg ggaggggttc caatactcct cgccctcgta ttctttctgt actgctgcat 4381 gaacagaaga ccctccatgc ctgcagcacc ccaagagatc cccatgtacc acctcgccag 4441 tcgagggtaa caccttccct cacttacctc tacaatccta gatagaaaaa aacggcacat 4501 atgtctgtgg acctcccaca gccgaccatg aactcaaaaa ccccaagcac cgacatcgca 4561 gcgttgaagg atctgctgag atacaaagtc acggtggcaa gacatgggtt cttatttgat 4621 gatggaaaga ttgtttggag cgaagatggg gatgaggcat ggaatagact ccttgttgtt 4681 gtcggggcat taaggtcctc taacaggatg agtcaggcac tgttcatgga catgagcatc 4741 accaaggggg acggatatct actcttctcc gacctgcagg gaacaaacaa tttgcagtac 4801 cggaccccaa aattcaggca atacctgttt ccagtagacg agttcctccc tctccccaga 4861 tagaaaaaaa tggcacttgt gtgcaaaaac aaaccaagcg aaagacgcga ttaactggac 4921 cgagacagca acggatccac tacatcatgg atttttttga tttagatata gagatcaagc 4981 aagagagact ccccgcggag tgctctctca actctcccct caacatctct ctatcatctc 5041 aactgaccga tcgtatgacc cctcaaaatg aaaacatccg gagacagaga gaaagaatca 5101 gaacccacac aaagacacac tctcgtatca aacacctatc aaaacttgac aatgactcaa 5161 ctagactcca tgcccgactt acagaagacc taatcaaact acagcatctt gaagtcgatt 5221 caccagtctt cgacaattgg gcccttctga catcttacta tgcagcccta gattacactc 5281 ttccagagag ggcgtcgttc gactggggac aggccgcacc atactggaac ctctacaccc 5341 aactccggac aatcctcctc cagagtcaaa agatcaggaa aaaagacaga ggggttaggg 5401 aaatctactc gtgcggccca cttcgccttg aatttgtgga aggcacggta ctgtacttca 5461 cagacaaaca atcagggggc gaatttacaa aatctggtga attgcccagc atcacaccct 5521 atgcagactt cctcgcctgg gtaaaaatca tttcccaacg agcacaagct gtcctgatgg 5581 cagtcattct cagagttaca gataaaggac tctcaccact tccggagtca ctgctctctg 5641 tctaccagac agttgatgac atcctgaaaa gagctggtca gccagccatt gacctgctga 5701 aactctggga gcccttagta atcaccaagt tgggagaact cctcggggac agatttgggc 5761 tcgaggagga ctttcgtctc acaatcagag gggaggccac gagactggcc aaaaaactag 5821 ccatcaccaa cggactgaac cggttgatga ccgtccttga ttcacaaaca gaagctcagc 5881 cgttgtttca gttctttgga ctcttcaaac atttcgcgta cccccgagtg ttctcaagag 5941 acacgattca ggccattcaa gaagtaagcg acagacccag ctcgatctca gcagctgaat 6001 tccttcatga ccaatgcgag ataagaaagg aattctacat caggtatctc aaggcatacc 6061 atcgagctcc gggcctggac ctgtcagccc ttagtccctc gtcttttctg agagagagtc 6121 ttgagcatgg aaaaatccca aacgagaaga gtccccatta ctcaaacaaa gagtggtact 6181 tcatcaaatt cacaaaaagc attgaatggc ccatcagtga cactctgtca acatttttat 6241 ccgacaaagc catcacaaga gatcgagcag catggatcga agaaggtcac tcaggtagag 6301 acatgtcaga aaaacgtctt ctcctcaaat tcatcaaaga aaacttctct agcgtggctg 6361 aaatcgtagc tgccgccgat gccatctaca acaacgaagg agacagactg atcgcactca 6421 aggtgaaaga gatggagtta aaaataaagg gacggggatt cgggctcatg actttcatgc 6481 cccggttact tcaggttctc cgagagagta ttgcaaagaa aaccagcaag ctgtttccgg 6541 aaatcaccat gacctcatct gacctggata tgaagaaaag aaaattcatg ctgtcaaaac 6601 gaagcgatga ccgacgtggt ttcatccaca tcaacaagag tctggacata aacaaattct 6661 gtaccagtca acggcaattc aactcaagtg ccgtgttctc tagtctggat gaaatgatgg 6721 gaacatttcc tcttttttcc cgggtccacg agattttcga aaaaacgtgg attgtggatg 6781 gttctgcatc tgatcccccg gatttatccc atttcaccag gattttggaa gagtgccgtc 6841 tgcatggaat tgaggcccct cacgtctggg cggacggagt attctctgga ctgaagggag 6901 gaatcgaggg actctgtcaa tatgtgtgga ccatctgcct cctcctcagg gtcgagcgag 6961 tcatgcagaa gaccaaactc acccactaca ttcttgcaca gggagacaat gtcatcatca 7021 ccattatagt ccccgtggag atacatcgcg atgggatcat ttcagaccaa gagtcccgtc 7081 gcctcctgac actgagccga aacatagatc tatccctaga aagtgaactg gaaaagagcg 7141 ggctgaccct aaagatcgag gagaccctaa cgagtgagaa catttcgatc tatgggaagg 7201 atcttcattg tccccaacat ctgacgcttg cactcaagaa ggcagcctct gcggcaatca 7261 tctccagtga acaatatcaa gacatcccca ccttcctgtc tggccttggg accagcctgg 7321 agtccctctc cgaatgcgtg aatagcaaaa caggggccca tctctttgga gtcttgatgg 7381 gggtagctgg atggaaggac ctcgccaccc accagacctg gaggggatgg aggtatccct 7441 atcacaaggc gccactctcg gggagggtcc gagcatctga tatgaaaatt ggaaagggtg 7501 aagcggttga gctcacgatc ccagtcatgt ctccaagaca acaggggaaa gagaccctaa 7561 gggaactcct cgccaacagt ctactgggat cagctctcgg aatgctcgcc tttcccactc 7621 cgatcgacct agagaagcgt ggggtaggag attacatcac acatcgtctg gcgattgcaa 7681 ggaaagccct cctgagcgag aaactggacc cccatattga aaaacgagta aggtccgcct 7741 gcaaccttcc cctctcttct cgggtggatc taagcaaatt attcgattcg cccttctcac 7801 tcaatctagc caccgaagaa gacgcaaccg cggtcattaa gcgacaggca aagaagaccc 7861 tccgactcca agagatcggg aacgacaagc tgagggccca aattggcaac atggacaagg 7921 gaatagccgc cctggacgca gacctagccg gggcagagac aatcaatccc cgcctgaacc 7981 acatgatcag ggacatcacg gatgaaaaag aatcggagat gttcgtaacc aagtttgcgt 8041 cggcgagaac tatgcggacc ctcgcaatgg gagactcatc cgaggtcccc atagtcgtgc 8101 tccttgaaaa gaagagccaa caaaaagaac tgtacaccat ctggagagcc agaagacccc 8161 acgccacgat gtggaaatgc tccacagtcc tggccaaggg cctacgcgac atttcctggg 8221 ggaagaccat tgtgggagtg acctcaccgt cccctatcga ggctatggaa accacacaca 8281 ttgatccgac agactgggag gacagcaggt cgagggagac cctctccatt aactactatc 8341 tttcaagagc ggggattgac gagcagaccg ccaagctcac tcgcggatct ctcgtcccct 8401 actatggaac tcaaacaaag ccactcatcg caaaagccta cctggaactg aagggcaacc 8461 ccagaacaaa caaggccctc ctcctgttaa gtgtccggga gtccctggtc aagacaggaa 8521 gcaatcttga cgaactaatc atgcaacttt gctcacatgc cctcgacatc gacgcagcgt 8581 ctcttcccgc actccgggca caagaggaag cgacagcagg ggagggtctt cggggtggaa 8641 taaaagaatc catgtcccct gtcgggcccg acaactttta caccaacatc acccataagg 8701 tgttcaacag gaagtgggtc acaccatacc atgtcaacat tgccgacttc atcattcagg 8761 gactcatcga gaccaggaaa cacctcatac tcaatgagaa gatggacgga ctacttcccc 8821 tgagctcagt caagtgtacc gcctgttttc ggaagaaaga gcgagaattc tttgacattc 8881 ccgagggacc gacatggaag aatgactcaa cgacctccga tcctgcctac acctatttca 8941 caacatggtg tgatctccca cgagtctcca ccctgcccac aatggatcag cagtcagcca 9001 ctcgtctact gggaagggga ctgtctctaa acagaccaac cgcaggcgaa atcatcacga 9061 agttctactc gatgtccatg gagtctcaga gactcctcca tcccgtggac ctactccttg 9121 ggtacggaga aggagtggtg tttggataca tcaggagtca acacatccac catggcgcac 9181 tctttcagac aaagagagag acactcacaa acaaactgcg caaattcatc ttggacacga 9241 agacacaaca tgccaaacag attggatatc tctttcaaga tgaagactcc ctgcatgagc 9301 tgatggctca agggctctgc ccctatgttc cacgatcaat tccactaacc atcaccgaac 9361 tgacgaatgc atgtgcgatc accaccattc gagccacaga agtcatccta agtgcaggct 9421 ctcgagtcgc tctgatgcca gtccaggcaa tcgacgagac cgacgttgac aacagccgtc 9481 ttgccgcgaa caccatgcag acaattctag gagattccag gccaatgaat ccggtatacc 9541 tggactgcga cctcaccacc aacatgaccg catgggagtc atccatcgag ctagacgttc 9601 tcaagtcaga gaattttcac attgacggac tacttatgga cctcaccgca agggaactcc 9661 cgatcagcga cacaccatgg aagcagaggg actggacatg ctccaacgac cctcgaatca 9721 ttgcaaaagg gatcaagacc aagtcactgt tcattcatca gggagtggca gaggcactga 9781 acatgacccc tgacctattg gtcgtgattg gaggaggcct cggcggctgc gcggttccgt 9841 atctccagga atgggcagat gtcccactga tattcgcaac tctgtttgac gagagagagc 9901 gaatctcaga ggacggggac ttggtggttc ctccagaaat tctcgtcaga gggatggccc 9961 ccaggatgat cgaaagagaa ctactggaag cggagctctg cgatgtcacc aatgacggaa 10021 atagaagact cctcacacga ctggtcaaga aaaatagggg aaagggaaca gtagtcctca 10081 tagacgagat agaaaacaga ggggctcccg agtcactcct tcagagctcg ctgcaggatc 10141 tcgtccggag actcgacaag gtctgcactc tgacctcgat acacactgtc cgggaatcca 10201 ccgtggaaca atttgcccag agaaccaact ccatcaaaag agacaggaag actgtgaccc 10261 tgcactggaa ccgctacaat cgaagggatc aatttgaggc tcttgtcatt gtcaagggag 10321 aggaaacacg ttcagattat cacgtgtcca ctgcgactgc agcacaggcc ttccgcaaga 10381 tcgacgaaca gctggaggta gaaggacgac tctctgccac aagatggtcc ctcccaactc 10441 tcccagcccg cgagaaggag atcctattcg gctatgtctc ctctgtcttt ttgaagacga 10501 atctcgttct ctccgcagat gacatggacc gagaaacact gctagaaacc atcgaggaca 10561 ctgcaccagg attgatctcc tggaaagaga aactcgagca ccgagatcat gcctttcggt 10621 cagacatcga cgaaaagggg atcacacagg acaaagtctt caacctcatc tgtctagcct 10681 gggtcataac cggactacgc tacggaatat gggaaaccga cgcgcaatcc atcatcacca 10741 agacggtcta catcacccga ggccccaagc tctgccctct tggagaaaaa ccaaaacggg 10801 tcttcgcatc cttcaaactt caaagtgata agagggtaga ggacgcaaaa ggatttctta 10861 gcgcgctgct acacctagag ggcttctttc ctcttggtag gcagtagccg gtctgtcccc 10921 tcccgcagcg cccagggacc cagcacccag atacaaaaaa acgagaccag tgttcccgtt 10981 cgggaaccca aaaatcacca ccccttcaga acctctctgt tacctttttt atac //