The detail information of Disorders of sexual development - sexual reversal
Basic Information

Disease Description: At fertilization, the sex chromosomes are established as XX (the animal will be female) or XY (male). During development of the embryo, ovaries develop if the chromosomes are XX, and testicles if XY. An abnormality can occur in chromosome differentiation (to produce XXY, XXX, XO). This is rare in dogs and is not thought to be inherited.

Inherit Mode: XX sex reversal is an autosomal recessive trait in the breeds listed below. It has been reported sporadically in several other breeds where the inheritance is not understood.

Disease Symptom: Affected animals are infertile (so that your apparently female dog will not come into heat), and may have chronic irritation in the genital area, which may look abnormal to you.

Disease Cause: -

Disease Diagnose: Your veterinarian will typically suspect one of these conditions when s/he notices an abnormality such as clitoral enlargement or an abnormal penis during physical examinataion of your dog, or if a breeding dog is being examined for infertility.To diagnose the specific condition requires your veterinarian to evaluate both internal (generally at the time of spay) and external sex organs, and send away a blood or other cell sample from your dog for karyotyping, which identifies the chromosomes.

Treat Method: Affected animals should be neutered.

Breeder Advice: Affected animals, their parents (carriers) and siblings (potential carriers) should not be used for breeding.

Disease Description Source: Link

Associated Diseases
Disease Name Other Name Mode of inheritance Link ID Possible OMIM ID Gene
Sex reversal, generic - - - -
XX testicular DSD (Disorder of Sexual Development) XX sex reversal, XX DSD testicular/ovotesticular Multifactorial -
Sex reversal: XY female, SRY-positive - - - HSD17B3
Associated Breeds
iDog Breed Number Breed Name Personality Height Weight Breed Source
CB11 American Staffordshire Terrier Confident, Smart, Good-natured 18-19 inches (male), 17-18 inches (female) 55-70 pounds (male), 40-55 pounds (female) United States
CB24 English Beagle Merry, friendly, and curious 33 cm & under 33-38.1 cm under 9.1 kg (5.9 inches & under), 9.1-13.6 kg (5.9-6.8 inches) United Kingdom (England)
CB78 Cocker Spaniel Happy, smart, gentle 36.8-39.4 cm (male), 34.3-36.8 cm (female) 11.3-13.6 kg (male), 9.1-11.3 kg (female)
CB111 German Short-Haired Pointer Friendly, smart, willing to please 58.4-63.5 cm (male), 53.3-58.4 cm (female) 24.9-31.8 kg (male), 20.4-27.2 kg (female) Germany
CB160 Miniature Pinscher Fearless, Fun-Loving, Proud 25.4-31.8 cm 3.6-4.5 kg Germany
CB170 Norwegian Elkhound Confident, dependable; dignified but friendly 52.1 cm (male), 49.5 cm (female) 24.9 kg (male), 21.8 kg (female) Norway
References
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