Another Name: cutaneous asthenia
Disease Description: A connective tissue disease characterized by loose, hyperextensible and very fragile skin that tears easily .
Inherit Mode: -
Disease Symptom: Symptoms are seen from birth, and can vary considerably in severity. They include: Fragile skin Loose or stretchy skin; Hyperextensible skin; Hanging folds of skin ;Looseness in joints; Connective tissue dysfunction;s Painful skin tears; Skin bruising; Subcutaneous hematoma, or hard blood masses under the skin ; Hygroma formations, or soft, fluid filled sacs that form over pressure points ;Delayed and poor wound healing; Extensive scarring from wound healing; Increased infections ;Lameness ;Pregnancy complications, uterine rupture or prolapse in females; Eye abnormalities; Dry and fine hair ;Weakened blood vessels
Disease Cause: Ehlers-Danlos syndrome is caused solely by an inherited gene that affects collagen production.
Disease Diagnose: A suspicion of Ehlers-Danlos syndrome is based on symptoms and a history of your dog, which may include lacerations, abscesses, and thin scars. To come to a positive diagnosis, your veterinarian will use a skin extensibility test to assess the hyper-elasticity of skin, using the skin extensibility index as a reference. A skin biopsy may be submitted to study the collagen structure and density.
Treat Method: There is no available cure for this condition. Treatment involves management of wounds and lifestyle modifications to accommodate your dog’s fragile, lifelong condition.Surgery may be required for large and deep tears as they occur, often with anesthesia. Vitamin C supplements have shown improvements in symptoms and may be prescribed.
Breeder Advice: -
Disease Description Source: Link
| Disease Name | Other Name | Mode of inheritance | Link ID | Possible OMIM ID | Gene |
|---|---|---|---|---|---|
| Ehlers-Danlos syndrome | - | - | - |
| iDog Breed Number | Breed Name | Personality | Height | Weight | Breed Source |
|---|---|---|---|---|---|
| CB25 | Bearded Collie | Bouncy, charismatic, friendly; smart, but also stubborn and independent | 53.3-55.9 cm (male), 50.8-53.3 cm (female) | 20.4-24.9 kg | United Kingdom (Scotland) |
| CB49 | Boykin Spaniel | Friendly, eager, trainable, lovable | 39.4-45.7 cm (male), 35.6-41.9 cm (female) | 13.6-18.1 kg (male), 11.3-15.9 kg (female) | United States |
| CB78 | Cocker Spaniel | Happy, smart, gentle | 36.8-39.4 cm (male), 34.3-36.8 cm (female) | 11.3-13.6 kg (male), 9.1-11.3 kg (female) | |
| CB98 | English Toy Spaniel | Affectionate, Alert, Merry | 22.9-25.4 cm | 3.6-6.4 kg | England |
| CB111 | German Short-Haired Pointer | Friendly, smart, willing to please | 58.4-63.5 cm (male), 53.3-58.4 cm (female) | 24.9-31.8 kg (male), 20.4-27.2 kg (female) | Germany |
| CB123 | Hamiltonstovare(Hamilton Hound) | Agile, Versatile, Regal | 53-61cm (male) 49-57cm (female) | 18-26kg | Sweden |
| CB233 | Stabyhoun | Friendly, sensitive, intelligent, peaceful, patient, and willing to please, but may be stubborn on occasion | Netherlands |
| 2019 |
Bauer,A.,Bateman,J.F.,Lamandé,S.R.,Hanssen,E.,Kirejczyk,S.G.M.,Yee,M.,Ramiche,A.,Jagannathan,V.,Welle,M.,Leeb,T.,Bateman,F.L.: :
Identification of Two Independent <i>COL5A1</i> Variants in Dogs with Ehlers-Danlos Syndrome. Genes (Basel) 10:, 2019. Pubmed reference: 31546637 . DOI: 10.3390/genes10100731 . |
| 2019 |
Bauer,A.,deLucia,M.,Leuthard,F.,Jagannathan,V.,Leeb,T.,Bauer,A.,deLucia,M.,Leuthard,F.,Jagannathan,V.,Leeb,T.: :
Compound heterozygosity for TNXB genetic variants in a mixed-breed dog with Ehlers-Danlos syndrome. Anim Genet 50:546-549, 2019. Pubmed reference: 31365140 . DOI: 10.1111/age.12830 . |
| 2015 |
Uri,M.,Verin,R.,Ressel,L.,Buckley,L.,McEwan,N.: :
Ehlers-Danlos Syndrome Associated with Fatal Spontaneous Vascular Rupture in a Dog. J Comp Pathol :, 2015. Pubmed reference: 25680848 . DOI: 10.1016/j.jcpa.2014.12.013 . |
| 2014 |
Halper,J.: :
Connective tissue disorders in domestic animals. Adv Exp Med Biol 802:231-40, 2014. Pubmed reference: 24443030 . DOI: 10.1007/978-94-007-7893-1_14 . |
| 2004 |
Barrera,R.,Mañe,C.,Duran,E.,Vives,M.A.,Zaragoza,C.: :
Ehlers-Danlos syndrome in a dog. Can Vet J 45:355-6, 2004. Pubmed reference: 15144116 . |
| 2003 |
Paciello,O.,Lamagna,F.,Lamagna,B.,Papparella,S.: :
Ehlers-Danlos-like syndrome in 2 dogs: clinical, histologic, and ultrastructural findings Veterinary Clinical Pathology 32:13-8, 2003. Pubmed reference: 12655483 . |
| 2003 |
Stoner,J.,Martin,G.,O'Mara,K.,Ehlers,J.,Tomlanovich,M.: :
Amiodarone and bretylium in the treatment of hypothermic ventricular fibrillation in a canine model. Acad Emerg Med 10:187-91, 2003. Pubmed reference: 12615580 . |
| 1998 |
Jelinek,F.,Karban,J.: :
Cutaneous asthenia in one dog Acta Veterinaria Brno 67:109 ff., 1998. |
| 1996 |
Rodriguez,F.,Herraez,P.,Delosmonteros,A.E.,Calabuig,P.,Rodriguez,J.L.: :
Collagen dysplasia in a litter of Garafiano shepherd dogs Zentralblatt Fur Veterinarmedizin - Reihe A 43:509-512, 1996. Pubmed reference: 8940898 . |
| 1993 |
White,S.D.: :
Congenital and genetic skin disease. Tijdschr Diergeneeskd 118 Suppl 1:53S-57S, 1993. Pubmed reference: 8480320 . |
| 1990 |
Matthews,B.R.,Lewis,G.T.: :
Ehlers-Danlos Syndrome in a Dog Canadian Veterinary Journal-Revue Veterinaire Canadienne 31:389-390, 1990. |
| 1989 |
Freeman,L.J.,Hegreberg,G.A.,Robinette,J.D.: :
Cutaneous wound healing in Ehlers-Danlos syndrome. Vet Surg 18:88-96, 1989. Pubmed reference: 2728341 . |
| 1989 |
Freeman,L.J.,Hegreberg,G.A.,Robinette,J.D.,Kimbrell,J.T.: :
Biomechanical properties of skin and wounds in Ehlers-Danlos syndrome. Vet Surg 18:97-102, 1989. Pubmed reference: 2728342 . |
| 1987 |
Freeman,L.J.,Hegreberg,G.A.,Robinette,J.D.: :
Ehlers-Danlos syndrome in dogs and cats. Semin Vet Med Surg (Small Anim) 2:221-7, 1987. Pubmed reference: 3423466 . |
| 1970 |
Hegreberg,G.A.,Padgett,G.A.,Henson,J.B.: :
A heritable connective tissue disease of dogs and mink resembling Ehlers- Danlos syndrome of man. III. Histopathologic changes of the skin Archives of Pathology 90:159-166, 1970. Pubmed reference: 5464798 . |
| 1970 |
Hegreberg,G.A.,Padgett,G.A.,Ott,R.L.,Henson,J.B.: :
A heritable connective tissue disease of dogs and mink resembling Ehlers-Danlos syndrome of man. I. Skin tensile strength properties. J Invest Dermatol 54:377-80, 1970. Pubmed reference: 5462224 . |
| 1969 |
Hegreberg,G.A.,Padgett,G.A.,Gorham,J.R.,Henson,J.B.: :
A connective tissue disease of dogs and mink resembling the Ehlers-Danlos syndrome of man. II. Mode of inheritance. J Hered 60:249-54, 1969. Pubmed reference: 5366318 . |