Another Name: stomatocytosis
Disease Description: A condition of Alaskan malamutes where there is malformation and maldevelopment of cartilage and red blood cells. Also called stomatocytosis because of the mouth-like shape of red blood cells.
Inherit Mode: -
Disease Symptom: In affected dogs, hematological analysis reveals macrocytosis, decreased MCHC, slightly increased red cell diameter width and reticulocytosis. Percentages of stomatocytes in blood films are usually icnrease significantly, varying from 0.6 to 18.9% of all erythrocytes.Erythrocyte osmotic fragility and intracellular Na+, K+ and 2,3-Diphosphoglycerate are frequently increased as well.In dogs, this condition is associated with nonspecific liver disease, chronic anemia and familial stomatocytosis-hypertrophic gastritis
Disease Cause: -
Disease Diagnose: -
Treat Method: -
Breeder Advice: -
Disease Description Source: Link
| iDog Breed Number | Breed Name | Personality | Height | Weight | Breed Source |
|---|---|---|---|---|---|
| CB5 | Alaskan Malamute | Affectionate, loyal, playful but dignified | 63.5 cm (male), 58.4 cm (female) | 38.6 kg (male), 34 kg (female) | United States |
| 2012 |
Shmukler BE et al :
Cation-leak stomatocytosis in standard schnauzers does not cosegregate with coding mutations in the RhAG, SLC4A1, or GLUT1 genes associated with human disease Blood Cells Mol Dis 48(4):219-225 Pubmed reference: _ . DOI: _ . |
| 2004 |
Bonfanti U et al :
Stomatocytosis in 7 related Standard Schnauzers Vet Clin Pathol 33(4):234-239 Pubmed reference: _ . DOI: _ . |
| 1996 |
Renooij W et al :
Gastric mucosal phospholipids in dogs with familial stomatocytosis-hypertrophic gastritis Eur J Clin Invest 26(12):1156-1159 Pubmed reference: _ . DOI: _ . |
| 1994 |
Brown DE et al :
Erythrocyte indices and volume distribution in a dog with stomatocytosis Vet Pathol 31(2):247-250 Pubmed reference: _ . DOI: _ . |
| 1994 |
Slappendel RJ et al :
Normal cations and abnormal membrane lipids in the red blood cells of dogs with familial stomatocytosis-hypertrophic gastritis Blood 84(3):904-909 Pubmed reference: _ . DOI: _ . |
| 1993 |
Stewart GW :
The membrane defect in hereditary stomatocytosis Baillieres Clin Haematol 6(2):371-399 Pubmed reference: _ . DOI: _ . |
| 1991 |
Slappendel RJ et al :
Familial stomatocytosis--hypertrophic gastritis (FSHG), a newly recognised disease in the dog (Drentse patrijshond) Vet Q 13(1):30-40 Pubmed reference: _ . DOI: _ . |
| 1983 |
Smith JE et al :
Glutathione metabolism in canine hereditary stomatocytosis with mild erythrocyte glutathione deficiency J Lab Clin Med 101(4):611-616 Pubmed reference: _ . DOI: _ . |
| 1975 |
Fletch SM et al :
The Alaskan malamute chondrodysplasia (dwarfism-anemia) syndrome - in review J Am Anim Hosp Assoc 11:353-336 Pubmed reference: _ . DOI: _ . |
| 1974 |
Pinkerton PH et al :
Hereditary stomatocytosis with hemolytic anemia in the dog Blood 44:557-567 Pubmed reference: _ . DOI: _ . |