The detail information of Hypotrichosis
Basic Information

Another Name: regional alopecia

Disease Description: A condition where there is an abnormally small amount of hair growth.

Inherit Mode: -

Disease Symptom: Diseases characterized by alopecia can be divided into scarring (or potentially scarring) and non-scarring disorders. In scarring alopecia, there is destruction or distortion of the follicle, usually as a consequence of an inflammatory process, which means that hair regrowth is not possible. A common example would be deep pyoderma secondary to demodicosis. By contrast, non-scarring alopecias generally result from structural or growth cycle abnormalities of the follicle without inflammation, and can be classified into four subtypes:atrophic alopecias,Follicular dysplasias,Matrix cell/melanocyte abnormalities,traumatic alopecias.

Disease Cause: -

Disease Diagnose: -

Treat Method: -

Breeder Advice: -

Disease Description Source: Link

Associated Diseases
Disease Name Other Name Mode of inheritance Link ID Possible OMIM ID Gene
Hypotrichosis, generic - Autosomal -
Hypotrichosis, recessive - Autosomal Recessive - SGK3
Alopecia areata - - -
Associated Breeds
iDog Breed Number Breed Name Personality Height Weight Breed Source
CB134 Irish Wolfhound Calm, dignified, kindly; courageous but not aggressive 81.3 cm minimum (male), 76.2 cm minimum (female) 54.4 kg (male), 47.6 kg (female) Ireland
References
2020 Parker,H.G.,Whitaker,D.T.,Harris,A.C.,Ostrander,E.A.: :
Whole Genome Analysis of a Single Scottish Deerhound Dog Family Provides Independent Corroboration That a <i>SGK3</i> Coding Variant Leads to Hairlessness. G3 (Bethesda) 10:293-297, 2020.
Pubmed reference: 31727632 . DOI: 10.1534/g3.119.400885 .
2019 Hytönen,M.K.,Lohi,H.: :
A frameshift insertion in SGK3 leads to recessive hairlessness in Scottish Deerhounds: a candidate gene for human alopecia conditions. Hum Genet 138:535-539, 2019.
Pubmed reference: 30927068 . DOI: 10.1007/s00439-019-02005-9 .
2017 Parker,H.G.,Harris,A.,Dreger,D.L.,Davis,B.W.,Ostrander,E.A.: :
The bald and the beautiful: hairlessness in domestic dog breeds. Philos Trans R Soc Lond B Biol Sci 372:, 2017.
Pubmed reference: 27994129 . DOI: 10.1098/rstb.2015.0488 .
2015 Ginel,P.J.,Blanco,B.,Pérez-Aranda,M.,Zafra,R.,Mozos,E.: :
Alopecia areata universalis in a dog. Vet Dermatol 26:379-83, e87, 2015.
Pubmed reference: 26123679 . DOI: 10.1111/vde.12232 .
2005 Sander,P.,Drögemüller,C.,Cadieu,E.,André,C.,Leeb,T.: :
Analysis of the canine EDAR gene and exclusion as a candidate for the hairless phenotype in the Chinese Crested dog. Anim Genet 36:168-71, 2005.
Pubmed reference: 15771734 . DOI: 10.1111/j.1365-2052.2005.01242.x .
2003 Alhaidari,Z.: :
[Alopecia areata in a mixed breed 9-year-old English setter] Annales de Dermatologie et de Venereologie 130:416, 2003.
Pubmed reference: 12843851 .
2003 Tobin,DJ.,Gardner,SH.,Luther,PB.,Dunston,SM.,Lindsey,NJ.,Olivry,T.: :
A natural canine homologue of alopecia areata in humans. Br J Dermatol 149:938-50, 2003.
Pubmed reference: 14632797 .
2000 Cerundolo,R.,Lloyd,D.H.,McNeil,P.E.,Evans,H.: :
An analysis of factors underlying hypotrichosis and alopecia in Irish Water spaniels in the United Kingdom Veterinary Dermatology 11:107-122, 2000.
2000 Cerundolo,R.,Lloyd,D.H.,McNeil,P.E.,Evans,H.: :
An analysis of factors underlying hypotrichosis and alopecia in Irish Water Spaniels in the United Kingdom (vol 11, pg 107, 2000) Veterinary Dermatology 11:313-314, 2000.
1999 Cerundolo,R.,Lloyd,D.H.,Pidduck,H.G.: :
Studies on the inheritance of hair loss in the Irish water spaniel Veterinary Record 145:542-544, 1999.
Pubmed reference: 10609570 .
1999 De,Meulemeester,J.,Lemmens,P.,Schrauwen,E.: :
Congenital hypotrichosis in male Border Collie littermates Vlaams Diergeneeskundig Tijdschrift 68:179-181, 1999.
1999 Kimura,T.,Doi,K.: :
Dorsal skin reactions of hairless dogs to topical treatment with corticosteroids Toxicologic Pathology 27:528-535, 1999.
Pubmed reference: 10528632 .
1998 Kimura,T.,Doi,K.: :
Efficacy of hydroquinone in the treatment of cutaneous hyperpigmentation in hairless descendants of Mexican hairless dogs (xoloitzcuintli) Laboratory Animal Science 48:469-475, 1998.
Pubmed reference: 10090060 .
1998 Kimura,T.,Doi,K.: :
Effects of indomethacin on sunburn and suntan reactions in hairless descendants of Mexican hairless dogs Histology & Histopathology 13:29-36, 1998.
1998 Kimura,T.,Doi,K.: :
Effects of all-trans-retinoic acid on the dorsal skin of hairless dogs Toxicologic Pathology 26:595-601, 1998.
Pubmed reference: 9789945 .
1997 Ishii,Y.,Kimura,T.,Itagaki,S.,Doi,K.: :
The skin injury induced by high energy dose of ultraviolet in hairless descendants of mexican hairless dogs Histology & Histopathology 12:383-389, 1997.
1997 Kimura,T.,Doi,K.: :
The effect of topical minoxidil treatment on hair follicular growth of neonatal hairless descendants of mexican hairless dogs Veterinary Dermatology 8:107-113, 1997.
1996 Kimura,T.: :
Studies on development of hairless descendants of Mexican hairless dogs and their usefulness in dermatological science [Review] Jikken Dobutsu. Experimental Animals 45:1-13, 1996.
1996 Kimura,T.,Doi,K.: :
Spontaneous comedones on the skin of hairless descendants of mexican hairless dogs Jikken Dobutsu. Experimental Animals 45:377-384, 1996.
1996 Schwartzman,R.M.,Kligman,A.M.,Duclos,D.D.: :
The Mexican hairless dog as a model for assessing the comedolytic and morphogenic activity of retinoids British Journal of Dermatology 134:64-70, 1996.
Pubmed reference: 8745888 .
1995 Ishii,Y.,Kimura,T.,Itagaki,S.,Doi,K.: :
Ultrastructure of the dorsal skins of hairless descendants derived from Mexican hairless dogs Jikken Dobutsu. Experimental Animals 44:353-357, 1995.
1995 Kimura,T.,Doi,K.: :
Dorsal skin reactions to sunlight and artificial ultraviolet light in hairless descendants of Mexican hairless dogs Jikken Dobutsu. Experimental Animals 44:293-299, 1995.
1994 Kimura,T.,Doi,K.: :
Responses of the Skin over the Dorsum to Sunlight in Hairless Descendants of Mexican Hairless Dogs American Journal of Veterinary Research 55:199-203, 1994.
Pubmed reference: 8172407 .
1994 Kimura,T.,Doi,K.: :
Age-Related Changes in Skin Color and Histologic Features of Hairless Descendants of Mexican Hairless Dogs American Journal of Veterinary Research 55:480-486, 1994.
Pubmed reference: 8017693 .
1994 Miyazawa,M.,Kimura,T.,Itagaki,S.: :
Lectin Histochemistry on the Skin of Hairless Descendants of Mexican Hairless Dogs Tissue & Cell 26:19-27, 1994.
Pubmed reference: 8171420 .
1993 Kimura,T.,Ohshima,S.,Doi,K.: :
The Inheritance and Breeding Results of Hairless Descendants of Mexican Hairless Dogs Laboratory Animals 27:55-58, 1993.
Pubmed reference: 8437436 .
1992 Iwamura,S.,Koizumi,N.,Matsubara,Y.,Honjo,K.,Fukuta,K.,Hirota,Y.: :
Changes in the Level of Plasma Cortisol, Progesterone and Total Testosterone in Developing Hairless Dogs Journal of Veterinary Medical Science 54:1217-1218, 1992.
Pubmed reference: 1477175 .
1992 Kimura,T.,Ohshima,S.,Doi,K.: :
Haematological and Serum Biochemical Values in Hairless and Haired Descendants of Mexican Hairless Dogs Laboratory Animals 26:214-218, 1992.
Pubmed reference: 1501437 .
1992 Koizumi,N.,Fukuta,K.: :
Lymphocyte Blastogenesis in Hairless Dogs Following Stimulation by Various Mitogens Experimental Animals 41:529-531, 1992.
Pubmed reference: 1451763 .
1992 Marks,A.,Vandenbroek,A.H.M.,Else,R.W.: :
Congenital Hypotrichosis in a French Bulldog Journal of Small Animal Practice 33:450-452, 1992.
1990 Hirota,Y.,Koizumi,N.,Matsubara,Y.,Imamura,K.,Fukuta,K.: :
Immunological Features in Hairless Descendants Derived from Mexican Hairless Dogs Japanese Journal of Veterinary Science 52:1117-1121, 1990.
Pubmed reference: 1704076 .
1990 Kimura,T.,Ohshima,S.,Iida,K.: :
Profile of Hematological Values in Hybrid Hairless Dogs Experimental Animals 39:417-420, 1990.
Pubmed reference: 2401328 .
1988 Sponenberg,D.P.,Scott,E.,Scott,W.: :
American hairless terriers: a recessive gene causing hairlessness in dogs. J Hered 79:69, 1988.
Pubmed reference: 3367039 .
1985 Robinson,R.: :
Chinese crested dog Journal of Heredity 76:217-218, 1985.
Pubmed reference: 3998444 .
1985 Guernsey,G.E.: :
Alopecia areata in a dog. Can Vet J 26:403, 1985.
Pubmed reference: 17422605 .
1983 Conroy,J.D.: :
An overview of immune-mediated mucocutaneous diseases in the dog and cat. II. Other diseases based on immunologic mechanisms. Am J Dermatopathol 5:595-9, 1983.
Pubmed reference: 6364878 .
1975 Conroy,J.D.,Rasmusen,B.A.,Small,E.: :
Hypotrichosis in Miniature Poodle siblings Journal of the American Veterinary Medical Association 166:697-699, 1975.
Pubmed reference: 1141043 .
1917 Anon.: :
The hairless dog Journal of Heredity 8:519-520, 1917.