The detail information of Cyclic neutropenia
Basic Information

Another Name: gray collie syndrome

Disease Description: A condition characterized by periodic lowering of neutrophils, a type of white blood cell. Commonly seen in grey collies.

Inherit Mode: In Collies the disease is associated with silver/gray gene and occurs in autosomal-recessive form.

Disease Symptom: Affected dogs bear a striking gray coat, which is different from the normal sable or tricolor coat, and have eye defects such as microphthalmia and scleral ectasia. The light-colored nose is a characteristic and diagnostic feature.Puppies are stunted and weak and less active at birth than their normal litter mates. The term 'cyclic' means the appearance of neutropenia alternating with normal neutrophil count. Beginning within 12 days after birth, the pups show marked sign of cyclic neutropenia associated with infections (diarrhea, conjunctivitis, gingivitis, or arthritis) at 11- to 14-day intervals.

Disease Cause: -

Disease Diagnose: -

Treat Method: Recent advances in stem cell transplantation showed a thrapeutic potential of allogeneic DLA-identical Hematopoietic Cell Transplantation (HCT) has been investigated for a wide range of canine non-malignant hematological and non-hematological disorders, such as congenital immunological and enzymatic deficiencies, and Duchenne muscular dystrophy. Allogeneic marrow grafts from dog leukocyte antigen (DLA)-identical littermates corrected cyclic neutropenia.

Breeder Advice: -

Disease Description Source: Link

Associated Diseases
Disease Name Other Name Mode of inheritance Link ID Possible OMIM ID Gene
Neutropenia, cyclic Grey Collie Syndrome; Gray Collie Syndrome Autosomal Recessive AP3B1
Associated Breeds
iDog Breed Number Breed Name Personality Height Weight Breed Source
CB78 Cocker Spaniel Happy, smart, gentle 36.8-39.4 cm (male), 34.3-36.8 cm (female) 11.3-13.6 kg (male), 9.1-11.3 kg (female)
CB80 Coton de Tulear Bright, happy-go-lucky, endlessly charming; born to love and to be loved 25.4-27.9 cm (male), 22.9-25.4 cm (female) 4.1-6.8 kg (male), 3.6-5.9 kg (female) Madagascar
CB188 Poodle Proud, active and very smart 25.4 cm & under (toy), 25.4-38.1 cm (miniature), over 38.1 cm (standard) 1.8-2.7 kg (toy), 4.5-6.8 kg (miniature), 27.2-31.8 kg (male standard), 18.1-22.7 kg (female standard) Germany, France
References
2010 Meng,R.,Bridgman,R.,Toivio-Kinnucan,M.,Niemeyer,GP.,Vernau,W.,Hock,T.,Lothrop,CD.: :
Neutrophil elastase-processing defect in cyclic hematopoietic dogs. Exp Hematol 38:104-15, 2010.
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2008 Pacheco,J.M.,Traulsen,A.,Antal,T.,Dingli,D.: :
Cyclic neutropenia in mammals. Am J Hematol 83:920-1, 2008.
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2004 Benson,KF.,Person,RE.,Li,FQ.,Williams,K.,Horwitz,M.: :
Paradoxical homozygous expression from heterozygotes and heterozygous expression from homozygotes as a consequence of transcriptional infidelity through a polyadenine tract in the AP3B1 gene responsible for canine cyclic neutropenia. Nucleic Acids Res 32:6327-33, 2004.
Pubmed reference: 15576359 . DOI: 10.1093/nar/gkh974 .
2004 Horwitz,M.,Benson,KF.,Duan,Z.,Li,FQ.,Person,RE.: :
Hereditary neutropenia: dogs explain human neutrophil elastase mutations. Trends Mol Med 10:163-70, 2004.
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2003 Benson,K.F.,Li,F.Q.,Person,R.E.,Albani,D.,Duan,Z.,Wechsler,J.,Meade-White,K.,Williams,K.,Acland,G.M.,Niemeyer,G.,Lothrop,C.D.,Horwitz,M.: :
Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase Nature Genetics 35:90-6, 2003.
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2003 Yanay,O.,Barry,S.C.,Katen,L.J.,Brzezinski,M.,Flint,L.Y.,Christensen,J.,Liggitt,D.,Dale,D.C.,Osborne,W.R.: :
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1996 Allen,W.M.,Pocock,P.I.,Dalton,P.M.,Richards,H.E.,Aitken,M.M.: :
Cyclic neutropenia in Collies Veterinary Record 138:371-372, 1996.
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1995 Brabb,T.,Maggioprice,L.,Dale,D.,Deeb,B.,Liggitt,D.: :
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1991 Lothrop,C.D.,Candler,R.V.,Pratt,H.L.,Urso,I.M.,Jones,J.B.,Carroll,R.C.: :
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1978 Dunn,C.D.R.,Jones,J.B.,Jolly,J.D.,Lange,R.D.: :
Cell proliferation of canine cyclic hematopoietic marrow in diffusion chambers Proceedings of the Society for Experimental Biology and Medicine 158:50-53, 1978.
Pubmed reference: 351627 .
1978 Yang,T.J.: :
Recovery of hair coat colour in Gray Collie (cyclic neutropenia) normal bone marrow transplant chimeras American Journal of Pathology 91:149-153, 1978.
Pubmed reference: 347941 .
1975 Cheville,N.F.: :
The Grey Collie syndrome (cyclic neutropenia) Journal of the American Animal Hospital Association 11:350-352, 1975.
1974 Adamson,J.W.,Dale,D.C.,Elm,R.J.: :
Regulation of cyclic erthropoiesis in the Grey Collie Journal of Clinical Investigation 52:1A abstract, 1974.
1974 Adamson,J.W.,Dale,D.C.,Elm,R.J.: :
Hematopoiesis in the Grey Collie dog : studies of the regulation of erythropoiesis Journal of Clinical Investigation 54:965-973, 1974.
Pubmed reference: 4430726 . DOI: 10.1172/JCI107837 .
1973 Patt,H.M.,Lund,J.E.,Maloney,M.A.: :
Cyclic hematopoiesis in grey Collie dogs: a stem cell problem Blood 42:873-884, 1973.
Pubmed reference: 4796766 .
1972 Dale,D.C.,Alling,D.W.,Wolff,S.M.: :
Cyclic hematopoiesis: the mechanism of cyclic neutropenia in Grey Collie dogs Journal of Clinical Investigation 51:2197-2204, 1972.
Pubmed reference: 5054472 . DOI: 10.1172/JCI107027 .
1971 Reynold,H.Y.,Dale,D.C.,Wolff,S.M.,Johnson,J.S.: :
Serum immunoglobulin levels in Grey Collies Society for Experimental Biology and Medicine 136:574-577, 1971.
1970 Lund,J.E.,Padgett,G.A.,Gorham,J.R.: :
Additional evidence on the inheritance of cyclic neutropenia in the dog Journal of Heredity 61:47-49, 1970.
Pubmed reference: 5529685 .
1967 Lund,J.E.,Padgett,G.A.,Ott,R.L.: :
Cyclic neutropenia in Grey Collie dogs Blood 29:452-461, 1967.
Pubmed reference: 6067150 .