The detail information of Prostate cancer
Basic Information

Disease Description: For male dogs that are intact (not neutered), various kinds of prostate problems (e.g. prostate enlargement, prostate infections) can occur, especially when they become older.

Inherit Mode: -

Disease Symptom: Dogs with this cancer show similar signs and symptoms as those with other prostate problems, such as prostate enlargement, although for prostate enlargement, the intensity of the signs is much lower.

Disease Cause: The cause of canine prostate cancer is not exactly clear, but some vets suspect that hormonal imbalance may be one possible cause.

Disease Diagnose: If this cancer is suspected in your dog, your veterinarian will suggest conducting initial tests such as urinalysis, x-rays and abdominal ultrasound.The vet may also do a digital rectal examination to feel if the prostate is enlarged.If these initial tests highly suggest cancer, a biopsy of the rectal wall is required to get a definitive diagnosis.

Treat Method: Unfortunately, treatment options are very limited for prostate cancer in dogs.

Breeder Advice: -

Disease Description Source: Link

Associated Diseases
There are no associated diseases in OMIA/CIDD.
Associated Breeds
There are associated breeds.
References
2021 Leis-Filho,A.F.,Lainetti,P.F.,Franzoni,M.S.,Palmieri,C.,Kobayshi,P.E.,Laufer-Amorim,R.,Fonseca-Alves,C.E.: :
A comparative in silico analysis of CD24's prognostic value in human and canine prostate cancer. J Pers Med 11:, 2021.
Pubmed reference: 33806857 . DOI: 10.3390/jpm11030232 .
2019 Costa,C.D.,Justo,A.A.,Kobayashi,P.E.,Story,M.M.,Palmieri,C.,LauferAmorim,R.,Fonseca-Alves,C.E.: :
Characterization of OCT3/4, Nestin, NANOG, CD44 and CD24 as stem cell markers in canine prostate cancer. Int J Biochem Cell Biol 108:21-28, 2019.
Pubmed reference: 30633985 . DOI: 10.1016/j.biocel.2019.01.002 .
2019 Palmieri,C.,Foster,R.A.,Grieco,V.,Fonseca-Alves,C.E.,Wood,G.A.,Culp,W.T.N.,MuruaEscobar,H.,DeMarzo,A.M.,Laufer-Amorim,R.: :
Histopathological Terminology Standards for the Reporting of Prostatic Epithelial Lesions in Dogs. J Comp Pathol 171:30-37, 2019.
Pubmed reference: 31540623 . DOI: 10.1016/j.jcpa.2019.07.005 .
2018 Fonseca-Alves,C.E.,Kobayashi,P.E.,RiveraCalderón,L.G.,Felisbino,S.L.,Rinaldi,J.C.,Drigo,S.A.,Rogatto,S.R.,Laufer-Amorim,R.: :
Immunohistochemical panel to characterize canine prostate carcinomas according to aberrant p63 expression. PLoS One 13:e0199173, 2018.
Pubmed reference: 29894516 . DOI: 10.1371/journal.pone.0199173 .
2009 Leroy,B.E.,Northrup,N.: :
Prostate cancer in dogs: comparative and clinical aspects. Vet J 180:149-62, 2009.
Pubmed reference: 18786842 . DOI: 10.1016/j.tvjl.2008.07.012 .
2002 Teske,E.,Naan,E.C.,vanDijk,E.M.,VanGarderen,E.,Schalken,J.A.: :
Canine prostate carcinoma: epidemiological evidence of an increased risk in castrated dogs. Mol Cell Endocrinol 197:251-5, 2002.
Pubmed reference: 12431819 . DOI: 10.1016/s0303-7207(02)00261-7 .
1992 Krawiec,D.R.,Heflin,D.: :
Study of prostatic disease in dogs: 177 cases (1981-1986). J Am Vet Med Assoc 200:1119-22, 1992.
Pubmed reference: 1376729 .