The detail information of Syringomyelia
OMIA Basic Information

Possible human homologues (MIM numbers):

Mendelian trait/disorder: no

Mode of inheritance: Multifactorial

Considered a defect: yes

Year key mutation first reported: -

Species-specific name: -

Species-specific symbol: -

More detail information can see in

Associated Breeds
There are associated breeds.
Associated Gene
There are no associated genes.
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Mondino,A.,Delucchi,L.,Moeser,A.,Cerdá-González,S.,Vanini,G.: :
Sleep Disorders in dogs: A Pathophysiological and Clinical Review. Top Companion Anim Med 43:100516, 2021.
Pubmed reference: 33556640 . DOI: 10.1016/j.tcam.2021.100516 .
2019 Thoefner,M.S.,Westrup,U.,Toft,N.,Bjerrum,O.J.,Berendt,M.: :
Mechanical sensory threshold in Cavalier King Charles spaniels with syringomyelia-associated scratching and control dogs. Vet J 246:92-97, 2019.
Pubmed reference: 30902196 . DOI: 10.1016/j.tvjl.2019.01.011 .
2017 Knowler,S.P.,Kiviranta,A.M.,McFadyen,A.K.,Jokinen,T.S.,LaRagione,R.M.,Rusbridge,C.: :
Craniometric Analysis of the Hindbrain and Craniocervical Junction of Chihuahua, Affenpinscher and Cavalier King Charles Spaniel Dogs With and Without Syringomyelia Secondary to Chiari-Like Malformation. PLoS One 12:e0169898, 2017.
Pubmed reference: 28121988 . DOI: 10.1371/journal.pone.0169898 .
2017 Wijnrocx,K.,VanBruggen,L.W.L.,Eggelmeijer,W.,Noorman,E.,Jacques,A.,Buys,N.,Janssens,S.,Mandigers,P.J.J.: :
Twelve years of chiari-like malformation and syringomyelia scanning in Cavalier King Charles Spaniels in the Netherlands: Towards a more precise phenotype. PLoS One 12:e0184893, 2017.
Pubmed reference: 28934242 . DOI: 10.1371/journal.pone.0184893 .
2015 Thøfner,M.S.,Stougaard,C.L.,Westrup,U.,Madry,A.A.,Knudsen,C.S.,Berg,H.,Jensen,C.S.,Handby,R.M.,Gredal,H.,Fredholm,M.,Berendt,M.: :
Prevalence and Heritability of Symptomatic Syringomyelia in Cavalier King Charles Spaniels and Long-term Outcome in Symptomatic and Asymptomatic Littermates. J Vet Intern Med 29:243-250, 2015.
Pubmed reference: 25308931 . DOI: 10.1111/jvim.12475 .
2015 Wrzosek,M.,Płonek,M.,Nicpoń,J.,Cizinauskas,S.,Pakozdy,A.: :
Retrospective multicenter evaluation of the "fly-catching syndrome" in 24 dogs: EEG, BAER, MRI, CSF findings and response to antiepileptic and antidepressant treatment. Epilepsy Behav 53:184-9, 2015.
Pubmed reference: 26584225 . DOI: 10.1016/j.yebeh.2015.10.013 .
2014 Knowler,S.P.,McFadyen,A.K.,Freeman,C.,Kent,M.,Platt,S.R.,Kibar,Z.,Rusbridge,C.: :
Quantitative analysis of Chiari-like malformation and syringomyelia in the Griffon Bruxellois dog. PLoS One 9:e88120, 2014.
Pubmed reference: 24533070 . DOI: 10.1371/journal.pone.0088120 .
2014 Mitchell,T.J.,Knowler,S.P.,vandenBerg,H.,Sykes,J.,Rusbridge,C.: :
Syringomyelia: determining risk and protective factors in the conformation of the Cavalier King Charles Spaniel dog. Canine Genet Epidemiol 1:9, 2014.
Pubmed reference: 26401326 . DOI: 10.1186/2052-6687-1-9 .
2013 Driver,C.J.,Watts,V.,Bunck,A.C.,VanHam,L.M.,Volk,H.A.: :
Assessment of cerebellar pulsation in dogs with and without Chiari-like malformation and syringomyelia using cardiac-gated cine magnetic resonance imaging. Vet J :, 2013.
Pubmed reference: 23770398 . DOI: 10.1016/j.tvjl.2013.05.017 .
2013 Fenn,J.,Schmidt,M.J.,Simpson,H.,Driver,C.J.,Volk,H.A.: :
Venous sinus volume in the caudal cranial fossa in Cavalier King Charles spaniels with syringomyelia. Vet J :, 2013.
Pubmed reference: 23755937 . DOI: 10.1016/j.tvjl.2013.05.007 .
2011 Knowler,S.P.,McFadyen,A.K.,Rusbridge,C.: :
Effectiveness of breeding guidelines for reducing the prevalence of syringomyelia. Vet Rec :, 2011.
Pubmed reference: 21998144 . DOI: 10.1136/vr.100062 .
2011 Parker,J.E.,Knowler,S.P.,Rusbridge,C.,Noorman,E.,Jeffery,N.D.: :
Prevalence of asymptomatic syringomyelia in Cavalier King Charles spaniels. Vet Rec 168:667, 2011.
Pubmed reference: 21672954 . DOI: 10.1136/vr.d1726 .
2010 Lewis,T.,Rusbridge,C.,Knowler,P.,Blott,S.,Woolliams,JA.: :
Heritability of syringomyelia in Cavalier King Charles spaniels. Vet J 183:345-7, 2010.
Pubmed reference: 19914109 . DOI: 10.1016/j.tvjl.2009.10.022 .
2010 Wolfe,KC.,Poma,R.: :
Syringomyelia in the Cavalier King Charles spaniel (CKCS) dog. Can Vet J 51:95-102, 2010.
Pubmed reference: 20357949 .
2009 Carruthers,H.,Rusbridge,C.,Dubé,M.P.,Holmes,M.,Jeffery,N.: :
Association between cervical and intracranial dimensions and syringomyelia in the cavalier King Charles spaniel. J Small Anim Pract 50:394-8, 2009.
Pubmed reference: 19689666 . DOI: 10.1111/j.1748-5827.2009.00768.x .
2009 Cerda-Gonzalez,S.,Olby,NJ.,Broadstone,R.,McCullough,S.,Osborne,JA.: :
Characteristics of cerebrospinal fluid flow in Cavalier King Charles Spaniels analyzed using phase velocity cine magnetic resonance imaging. Vet Radiol Ultrasound 50:467-76, 2009.
Pubmed reference: 19788029 .
2009 Mandigers,P.,Rusbridge,C.: :
[Chiari-like malformation--syringomyelia in the Cavalier King Charles Spaniel] Tijdschr Diergeneeskd 134:746-50, 2009.
Pubmed reference: 19911737 .
2009 Park,C.,Kang,BT.,Yoo,JH.,Park,HM.: :
Syringomyelia in three small breed dogs secondary to Chiari-like malformation: clinical and diagnostic findings. J Vet Sci 10:365-7, 2009.
Pubmed reference: 19934606 .
2009 Rusbridge,C.,Knowler,SP.,Pieterse,L.,McFadyen,AK.: :
Chiari-like malformation in the Griffon Bruxellois. J Small Anim Pract 50:386-93, 2009.
Pubmed reference: 19689665 . DOI: 10.1111/j.1748-5827.2009.00744.x .
2008 Chandler,K.,Volk,H.,Rusbridge,C.,Jeffery,N.: :
Syringomyelia in cavalier King Charles spaniels. Vet Rec 162:324, 2008.
Pubmed reference: 18326849 .
2008 Kitagawa,M.,Ueno,H.,Watanabe,S.,Igarashi,O.,Uzuka,Y.,Kanayama,K.,Sakai,T.: :
Clinical improvement in two dogs with hydrocephalus and syringohydromyelia after ventriculoperitoneal shunting. Aust Vet J 86:36-42, 2008.
Pubmed reference: 18271823 . DOI: 10.1111/j.1751-0813.2007.00247.x .
2008 Rusbridge,C.,Jeffery,ND.: :
Pathophysiology and treatment of neuropathic pain associated with syringomyelia. Vet J 175:164-72, 2008.
Pubmed reference: 17317245 . DOI: 10.1016/j.tvjl.2006.12.007 .
2008 Stalin,CE.,Rusbridge,C.,Granger,N.,Jeffery,ND.: :
Radiographic morphology of the cranial portion of the cervical vertebral column in Cavalier King Charles Spaniels and its relationship to syringomyelia. Am J Vet Res 69:89-93, 2008.
Pubmed reference: 18167092 . DOI: 10.2460/ajvr.69.1.89 .
2007 Rusbridge,C.,Carruthers,H.,Dubé,M.P.,Holmes,M.,Jeffery,N.D.: :
Syringomyelia in cavalier King Charles spaniels: the relationship between syrinx dimensions and pain. J Small Anim Pract 48:432-6, 2007.
Pubmed reference: 17608656 . DOI: 10.1111/j.1748-5827.2007.00344.x .
2006 Jung,DI.,Park,C.,Kang,BT.,Kim,JW.,Kim,HJ.,Lim,CY.,Jeong,SW.,Park,HM.: :
Acquired cervical syringomyelia secondary to a brainstem meningioma in a maltese dog. J Vet Med Sci 68:1235-8, 2006.
Pubmed reference: 17146188 .
2006 MacKillop,E.,Schatzberg,SJ.,deLahunta,A.: :
Intracranial epidermoid cyst and syringohydromyelia in a dog. Vet Radiol Ultrasound 47:339-44, 2006.
Pubmed reference: 16863050 .
2006 Rusbridge,C.,Greitz,D.,Iskandar,BJ.: :
Syringomyelia: current concepts in pathogenesis, diagnosis, and treatment. J Vet Intern Med 20:469-79, 2006.
Pubmed reference: 16734077 .
2006 Rusbridge,C.,Knowler,SP.: :
Coexistence of occipital dysplasia and occipital hypoplasia/syringomyelia in the cavalier King Charles spaniel. J Small Anim Pract 47:603-6, 2006.
Pubmed reference: 17004953 . DOI: 10.1111/j.1748-5827.2006.00048.x .
2005 Hasegawa,T.,Taura,Y.,Kido,H.,Shibazaki,A.,Katamoto,H.: :
Surgical management of combined hydrocephalus, syringohydromyelia, and ventricular cyst in a dog. J Am Anim Hosp Assoc 41:267-72, 2005.
Pubmed reference: 15995165 .
2005 Rusbridge,C.,Knowler,P.,Rouleau,GA.,Minassian,BA.,Rothuizen,J.: :
Inherited occipital hypoplasia/syringomyelia in the cavalier King Charles spaniel: experiences in setting up a worldwide DNA collection. J Hered 96:745-9, 2005.
Pubmed reference: 15958797 . DOI: 10.1093/jhered/esi074 .
2005 Takagi,S.,Kadosawa,T.,Ohsaki,T.,Hoshino,Y.,Okumura,M.,Fujinaga,T.: :
Hindbrain decompression in a dog with scoliosis associated with syringomyelia. J Am Vet Med Assoc 226:1359-63, 1347, 2005.
Pubmed reference: 15844429 .
2004 Rusbridge,C.,Knowler,SP.: :
Inheritance of occipital bone hypoplasia (Chiari type I malformation) in Cavalier King Charles Spaniels. J Vet Intern Med 18:673-8, 2004.
Pubmed reference: 15515584 .
2000 Bagley,R.S.,Gavin,P.R.,Silver,G.M.,Moore,M.P.,Kippenes,H.,Connors,R.: :
Syringomyelia and hydromyelia in dogs and cats Compendium on Continuing Education for the Practicing Veterinarian 22:471-479, 2000.
2000 Rusbridge,C.,MacSweeny,J.E.,Davies,J.V.,Chandler,K.,Fitzmaurice,S.N.,Dennis,R.,Cappello,R.,Wheeler,S.J.: :
Syringohydromyelia in Cavalier King Charles spaniels Journal of the American Animal Hospital Association 36:34-41, 2000.
Pubmed reference: 10667404 .
2000 Taga,A.,Taura,Y.,Nakaichi,M.,Wada,N.,Hasegawa,T.: :
Magnetic resonance imaging of syringomyelia in five dogs Journal of Small Animal Practice 41:362-365, 2000.
Pubmed reference: 11002940 .
1996 Itoh,T.,Nishimura,R.,Matsunaga,S.,Kodosawa,T.,Mochizuki,M.,Sasaki,N.: :
Syringomyelia and hydrocephalus in a dog Journal of the American Veterinary Medical Association 209:934 ff., 1996.
1973 Furneaux,R.W.,Doige,C.E.,Kaye,M.M.: :
Syringomyelia and spina bifida occulta in a Samoyed dog. Can Vet J 14:317-21, 1973.
Pubmed reference: 4588835 .
1965 McGrath,J.T.: :
Spinal dysraphism in the dog, with comments on syringomylia Pathologia Veterinaria 2:1-36 (Supplement), 1965.
Pubmed reference: 5893238 .