Basic information
Locus name	AT4G04460
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Protein degradation/modification
Effect for Senescence	unclear
Gene Description	aspartyl protease family protein contains Pfam profiles: PF00026 eukaryotic aspartyl protease, PF03489 surfactant protein B, PF05184 saposin-like type B, region 1
Evidence	Genomic evidence:microarray data [Ref 1]
References	1: Buchanan-Wollaston V, Page T, Harrison E, Breeze E, Lim PO, Nam HG, Lin JF, Wu SH, Swidzinski J, Ishizaki K, Leaver CJ Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis. Plant J. 2005 May;42(4):567-85
Gene Ontology	biological process proteolysis molecular function aspartic-type endopeptidase activity
Sequence	AT4G04460.1 | Genomic | mRNA | CDS | Protein
Microarray
Sampling	Buchanan-Wollaston V, Page T, Harrison E, Breeze E, Lim PO, Nam HG, Lin JF, Wu SH, Swidzinski J, Ishizaki K, Leaver CJ. Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis. Plant J. 2005 May;42(4)
Comparation	Legends: Col: wild type, indicates the ratio of expression in senescing leaves/green leaves. NahG, coi1 and ein2: indicates the ratio of expression in senescing leaves of mutant/senescing wild type. CD: Cell Death, ratio of starved cell suspension culture/control. Genes showing at least 3 fold (ratio) up regulation during leaf senescence.
Ortholog Group
Ortholog Groups: OG5_126885	Accession Taxon NP_001031219 Arabidopsis thaliana NP_172655 Arabidopsis thaliana NP_176419 Arabidopsis thaliana NP_192355 ( AT4G04460 ) Arabidopsis thaliana 128744 Chlamydomonas reinhardtii ACO70184 Micromonas sp. RCC299 NP_001042785 Oryza sativa Japonica Group NP_001043650 Oryza sativa Japonica Group NP_001043786 Oryza sativa Japonica Group NP_001054586 Oryza sativa Japonica Group NP_001056348 Oryza sativa Japonica Group estExt_fgenesh1_pg.C_Chr_11.00010225 Ostreococcus tauri estExt_Genewise1.C_990066 Physcomitrella patens subsp. patens estExt_fgenesh2_pg.C_1130012 Physcomitrella patens subsp. patens estExt_gwp_gw1.C_930054 Physcomitrella patens subsp. patens 29842.m003556 Ricinus communis 30010.m000674 Ricinus communis 30064.m000505 Ricinus communis 30128.m008981 Ricinus communis e_gw1.9.122.1 Thalassiosira pseudonana CCMP1335 estExt_gwp_gw1.C_chr_80283 Thalassiosira pseudonana CCMP1335 XP_002951885 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR13683 3.2E-270 1 507 IPR001461 Peptidase A1 ProSiteProfiles PS51257 5.0 1 16 No hit NA SUPERFAMILY SSF50630 3.3E-117 13 322 IPR021109 Aspartic peptidase Pfam PF00026 1.2E-123 86 507 IPR001461 Peptidase A1 PRINTS PR00792 1.4E-28 93 113 IPR001461 Peptidase A1 ProSitePatterns PS00141 NA 102 113 IPR001969 Peptidase aspartic, active site PRINTS PR00792 1.4E-28 239 252 IPR001461 Peptidase A1 PRINTS PR00792 1.4E-28 289 300 IPR001461 Peptidase A1 ProSitePatterns PS00141 NA 289 300 IPR001969 Peptidase aspartic, active site ProSiteProfiles PS50015 12.5 317 357 IPR008139 Saposin B SUPERFAMILY SSF47862 1.4E-23 318 417 IPR011001 Saposin-like Pfam PF03489 1.1E-12 319 353 IPR008138 Saposin-like type B, 2 ProSiteProfiles PS50015 9.9 378 419 IPR008139 Saposin B Pfam PF05184 2.5E-10 380 417 IPR007856 Saposin-like type B, 1 SUPERFAMILY SSF50630 3.3E-117 424 507 IPR021109 Aspartic peptidase PRINTS PR00792 1.4E-28 481 496 IPR001461 Peptidase A1
Subcellular Localization
Localization	vacuole
Evidence	SUBAcon
Pubmed ID	23180787