Basic information
Locus name	At5g17860
Alias	CCX1
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Calcium exchanger
Effect for Senescence	promote
Gene Description	calcium exchanger 7
Evidence	Genetic evidence [Ref 1]
References	1: Li Z, Wang X, Chen J, Gao J, Zhou X, Kuai B. CCX1, a Putative Cation/Ca2+ Exchanger, Participates in Regulation of Reactive Oxygen Species Homeostasis and Leaf Senescence. Plant Cell Physiol. 2016 Dec;57(12):2611-2619. Epub 2016 Oct 25.
Gene Ontology	biological process transmembrane transport cellular component integral to membrane
Pathway	Reactome REACT_15518
Sequence	AT5G17860.1 | Genomic | mRNA | CDS | Protein
Mutant information
Mutant name	ccx1-1 (SALK_035514)
Mutant/Transgenic	mutant
Ecotype	Col-0
Mutagenesis type	T-DNA
Microarray
Sampling	Buchanan-Wollaston V, Page T, Harrison E, Breeze E, Lim PO, Nam HG, Lin JF, Wu SH, Swidzinski J, Ishizaki K, Leaver CJ. Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis. Plant J. 2005 May;42(4)
Comparation	Legends: Col: wild type, indicates the ratio of expression in senescing leaves/green leaves. NahG, coi1 and ein2: indicates the ratio of expression in senescing leaves of mutant/senescing wild type. D/L: ratio of DARK 5d/control. CD: Cell Death, ratio of starved cell suspension culture/control. Genes showing at least 3 fold (ratio) up regulation during leaf senescence.
Ortholog Group
Ortholog Groups: OG5_127811	Accession Taxon NP_172370 Arabidopsis thaliana NP_197288 ( At5g17860 ) Arabidopsis thaliana NP_564650 Arabidopsis thaliana NP_566474 Arabidopsis thaliana 196017 Chlamydomonas reinhardtii 205918 Chlamydomonas reinhardtii ACO63315 Micromonas sp. RCC299 ACO65591 Micromonas sp. RCC299 ACO66371 Micromonas sp. RCC299 NP_001049159 Oryza sativa Japonica Group NP_001050809 Oryza sativa Japonica Group NP_001064673 Oryza sativa Japonica Group NP_001067316 Oryza sativa Japonica Group 0400010445 Ostreococcus tauri estExt_fgenesh1_pg.C_Chr_05.00010047 Ostreococcus tauri e_gw1.1.499.1 Physcomitrella patens subsp. patens gw1.254.44.1 Physcomitrella patens subsp. patens gw1.90.152.1 Physcomitrella patens subsp. patens 27789.m000069 Ricinus communis 29739.m003745 Ricinus communis 30072.m000939 Ricinus communis 30128.m008749 Ricinus communis estExt_fgenesh1_pg.C_chr_10913 Thalassiosira pseudonana CCMP1335 estExt_fgenesh1_pg.C_chr_140125 Thalassiosira pseudonana CCMP1335 fgenesh1_pg.C_chr_17000029 Thalassiosira pseudonana CCMP1335 fgenesh1_pg.C_chr_6000011 Thalassiosira pseudonana CCMP1335 XP_002952446 Volvox carteri f. nagariensis XP_002952905 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR12266 3.2E-142 8 570 No hit NA Pfam PF01699 4.4E-27 119 248 IPR004837 Sodium/calcium exchanger membrane region Pfam PF01699 5.1E-24 416 556 IPR004837 Sodium/calcium exchanger membrane region
Mutant Image
a member of the cation/Ca2+ exchanger family, CCX1, is highly induced during leaf senescence in Arabidopsis. Although single mutation of CCX1 did not change the senescence phenotype, double mutation of CCX1 and CCX4 resulted in a subtle but significant stay-green phenotype during natural and dark-induced leaf senescence, suggesting that some members of the cation/Ca2+ exchanger family act redundantly in mediating leaf senescence.