Basic information
Locus name	AT4G36400
Alias	D-2HGDH
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Lipid/Carbohydrate metabolism
Effect for Senescence	delay
Gene Description	D-2-hydroxyglutarate dehydrogenase (D-2HGDH) catalyses the specific and efficient oxidation of D-2HG into 2-oxoglutarate using FAD as cofactor. D-2HGDH localizes to plant mitochondria and that its expression increases gradually during developmental and dark-induced senescence in Arabidopsis thaliana.This gene encodes an ortholog to Saccharomyces cerevisiaed-lactate dehydrogenase (AtD-LDH)
Evidence	Genetic evidence:Mutant [Ref 1]
References	1: Engqvist MK, Kuhn A, Wienstroer J, Weber K, Jansen EE, Jakobs C, Weber AP, Maurino VG Plant D-2-hydroxyglutarate dehydrogenase participates in the catabolism of lysine especially during senescence. J. Biol. Chem. 2011 Apr 1;286(13):11382-90
Gene Ontology	biological process oxidation-reduction process molecular function UDP-N-acetylmuramate dehydrogenase activity catalytic activity flavin adenine dinucleotide binding oxidoreductase activity
Pathway	KEGG map00520 (EC 1.1.1.158) map00550 (EC 1.1.1.158) MetaCyc PWY-6386
Sequence	AT4G36400.1 | Genomic | mRNA | CDS | Protein AT4G36400.2 | Genomic | mRNA | CDS | Protein
Mutant information
Mutated 1 Mutant name d2hgdh1-1 Mutant/Transgenic mutant Ecotype Col-0 Mutagenesis type T-DNA insertion_knock out
Mutated 2 Mutant name d2hgdh1-3 Mutant/Transgenic mutant Ecotype Col-0 Mutagenesis type T-DNA insertion_knock out
Ortholog Group
Ortholog Groups: OG5_128784	Accession Taxon NP_568003 Arabidopsis thaliana NP_974692 ( AT4G36400 ) Arabidopsis thaliana CMR349C Cyanidioschyzon merolae strain 10D 122423 Chlamydomonas reinhardtii ACO63898 Micromonas sp. RCC299 NP_001059074 Oryza sativa Japonica Group e_gw1.01.00.208.1 Ostreococcus tauri e_gw1.6.69.1 Physcomitrella patens subsp. patens 29634.m002061 Ricinus communis estExt_gwp_gw1.C_chr_200110 Thalassiosira pseudonana CCMP1335 XP_002953529 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR11748 0.0 2 553 No hit NA SUPERFAMILY SSF56176 5.6E-64 100 308 IPR016166 FAD-binding, type 2 ProSiteProfiles PS51387 24.4 130 309 IPR016166 FAD-binding, type 2 Pfam PF01565 7.9E-32 137 271 IPR006094 FAD linked oxidase, N-terminal SUPERFAMILY SSF55103 3.1E-52 283 554 IPR016164 FAD-linked oxidase-like, C-terminal Pfam PF02913 6.0E-60 312 551 IPR004113 FAD-linked oxidase, C-terminal
Subcellular Localization
Localization	mitochondrion
Evidence	SUBAcon
Pubmed ID	23180787