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Locus name | AT4G36400 |
Alias | D-2HGDH |
Organism | Arabidopsis thaliana |
Taxonomic identifier | [NCBI] |
Function category | Lipid/Carbohydrate metabolism |
Effect for Senescence | delay |
Gene Description | D-2-hydroxyglutarate dehydrogenase (D-2HGDH) catalyses the specific and efficient oxidation of D-2HG into 2-oxoglutarate using FAD as cofactor. D-2HGDH localizes to plant mitochondria and that its expression increases gradually during developmental and dark-induced senescence in Arabidopsis thaliana.This gene encodes an ortholog to Saccharomyces cerevisiaed-lactate dehydrogenase (AtD-LDH) |
Evidence | Genetic evidence:Mutant [Ref 1] |
References | 1: Engqvist MK, Kuhn A, Wienstroer J, Weber K, Jansen EE, Jakobs C, Weber AP, Maurino VGPlant D-2-hydroxyglutarate dehydrogenase participates in the catabolism of lysine especially during senescence.J. Biol. Chem. 2011 Apr 1;286(13):11382-90 |
Gene Ontology | |
Pathway | |
Sequence | AT4G36400.1 | Genomic | mRNA | CDS | Protein AT4G36400.2 | Genomic | mRNA | CDS | Protein
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Mutated 1 | Mutant name |
d2hgdh1-1 | Mutant/Transgenic |
mutant | Ecotype |
Col-0 |
Mutagenesis type |
T-DNA insertion_knock out |
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Mutated 2 | Mutant name |
d2hgdh1-3 | Mutant/Transgenic |
mutant | Ecotype |
Col-0 |
Mutagenesis type |
T-DNA insertion_knock out |
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Ortholog Group | |
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Ortholog Groups: OG5_128784 | |
Cross Link | |
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Localization | mitochondrion |
Evidence | SUBAcon |
Pubmed ID | 23180787 |