Basic information
Locus name	AT1G54210
Alias	ATG12A
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Nutrient recycling:Autophagy
Effect for Senescence	delay
Gene Description	Involved in autophagy, protein ubiquitination during ubiquitin-dependent protein catabolic process, autophagic vacuole formation
Evidence	Molecular evidence [Ref 1, Ref 2, Ref 3]
References	1: Doelling JH, Walker JM, Friedman EM, Thompson AR, Vierstra RD The APG8/12-activating enzyme APG7 is required for proper nutrient recycling and senescence in Arabidopsis thaliana. J. Biol. Chem. 2002 Sep 6;277(36):33105-14 2: Hanaoka H, Noda T, Shirano Y, Kato T, Hayashi H, Shibata D, Tabata S, Ohsumi Y Leaf senescence and starvation-induced chlorosis are accelerated by the disruption of an Arabidopsis autophagy gene. Plant Physiol. 2002 Jul;129(3):1181-93 3: Thompson AR, Doelling JH, Suttangkakul A, Vierstra RD Autophagic nutrient recycling in Arabidopsis directed by the ATG8 and ATG12 conjugation pathways. Plant Physiol. 2005 Aug;138(4):2097-110
Gene Ontology	biological process autophagic vacuole assembly cellular component cytoplasm
Sequence	AT1G54210.1 | Genomic | mRNA | CDS | Protein
Ortholog Group
Ortholog Groups: OG5_130185	Accession Taxon NP_175823 ( AT1G54210 ) Arabidopsis thaliana NP_188013 Arabidopsis thaliana 194981 Chlamydomonas reinhardtii ACO64599 Micromonas sp. RCC299 NP_001057089 Oryza sativa Japonica Group estExt_gwp_gw1.C_1020075 Physcomitrella patens subsp. patens 29706.m001289 Ricinus communis e_gw1.6.610.1 Thalassiosira pseudonana CCMP1335
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR13385 6.6E-58 1 96 IPR007242 Ubiquitin-like protein Atg12 SUPERFAMILY SSF54236 1.2E-27 12 95 No hit NA Pfam PF04110 3.4E-35 13 96 IPR007242 Ubiquitin-like protein Atg12
Mutant Image
atg12a (SALK_086079) mutant exhibited early senescence phenotype compared with wild type Col-0 (7-week-old) .
Subcellular Localization
Localization	cytosol
Evidence	SUBAcon
Pubmed ID	23180787