Basic information
Locus name	AT1G63970
Alias	ISPF
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Chlorophyll biosynthesis
Effect for Senescence	unclear
Gene Description	Encodes a protein with 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity. carotenoid biosynthetic process, chlorophyll biosynthetic process, chloroplast, chloroplast stroma, isopentenyl diphosphate biosynthetic process, isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway, mevalonate-independent pathway.
Evidence	Molecular evidence:Blast search [Ref 1]
References	1: Snowden KC, Simkin AJ, Janssen BJ, Templeton KR, Loucas HM, Simons JL, Karunairetnam S, Gleave AP, Clark DG, Klee HJ The Decreased apical dominance1/Petunia hybrida CAROTENOID CLEAVAGE DIOXYGENASE8 gene affects branch production and plays a role in leaf senescence, root growth, and flower development. Plant Cell 2005 Mar;17(3):746-59
Gene Ontology	biological process terpenoid biosynthetic process molecular function 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Pathway	KEGG map00900 (EC 4.6.1.12)
Sequence	AT1G63970.1 | Genomic | mRNA | CDS | Protein AT1G63970.2 | Genomic | mRNA | CDS | Protein
Mutant information
Mutant name	ispF-1
Mutant/Transgenic	mutant
Ecotype	Col-0
Mutagenesis type	T-DNA insertion_knock out
Ortholog Group
Ortholog Groups: OG5_130616	Accession Taxon NP_564819 Arabidopsis thaliana NP_850971 ( AT1G63970 ) Arabidopsis thaliana CMT435C Cyanidioschyzon merolae strain 10D 188593 Chlamydomonas reinhardtii ACO70631 Micromonas sp. RCC299 NP_001047741 Oryza sativa Japonica Group gw1.11.00.289.1 Ostreococcus tauri e_gw1.312.36.1 Physcomitrella patens subsp. patens 30190.m011273 Ricinus communis e_gw1.15.122.1 Thalassiosira pseudonana CCMP1335 XP_002947986 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR32125 3.3E-51 28 223 No hit NA SUPERFAMILY SSF69765 2.0E-50 74 222 IPR003526 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Hamap MF_00107 27.7 75 222 IPR003526 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Pfam PF02542 8.5E-51 75 222 IPR003526 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase TIGRFAM TIGR00151 2.8E-49 76 222 IPR003526 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Subcellular Localization
Localization	plastid
Evidence	SUBAcon
Pubmed ID	23180787