Basic information
Locus name	AT2G46450
Alias	CNGC12
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Defense
Effect for Senescence	unclear
Gene Description	Member of Cyclic nucleotide gated channel family.Positive regulator of resistance against avirulent fungal pathogen.
Evidence	Molecular evidence:Blast search [Ref 1]
References	1: Snowden KC, Simkin AJ, Janssen BJ, Templeton KR, Loucas HM, Simons JL, Karunairetnam S, Gleave AP, Clark DG, Klee HJ The Decreased apical dominance1/Petunia hybrida CAROTENOID CLEAVAGE DIOXYGENASE8 gene affects branch production and plays a role in leaf senescence, root growth, and flower development. Plant Cell 2005 Mar;17(3):746-59
Gene Ontology	biological process ion transport transmembrane transport cellular component membrane molecular function ion channel activity protein binding
Sequence	AT2G46450.1 | Genomic | mRNA | CDS | Protein AT2G46450.2 | Genomic | mRNA | CDS | Protein AT2G46450.3 | Genomic | mRNA | CDS | Protein
Ortholog Group
Ortholog Groups: OG5_131975	Accession Taxon NP_001118537 Arabidopsis thaliana NP_173051 Arabidopsis thaliana NP_173408 Arabidopsis thaliana NP_180393 Arabidopsis thaliana NP_182167 Arabidopsis thaliana NP_190384 Arabidopsis thaliana NP_192010 Arabidopsis thaliana NP_194765 Arabidopsis thaliana NP_194785 Arabidopsis thaliana NP_196991 Arabidopsis thaliana NP_200125 Arabidopsis thaliana NP_200602 Arabidopsis thaliana NP_563625 Arabidopsis thaliana NP_565560 Arabidopsis thaliana NP_566075 Arabidopsis thaliana NP_850056 Arabidopsis thaliana NP_850454 ( AT2G46450 ) Arabidopsis thaliana NP_851209 Arabidopsis thaliana NP_974953 Arabidopsis thaliana NP_001047485 Oryza sativa Japonica Group NP_001048351 Oryza sativa Japonica Group NP_001050768 Oryza sativa Japonica Group NP_001057767 Oryza sativa Japonica Group NP_001063911 Oryza sativa Japonica Group NP_001066227 Oryza sativa Japonica Group e_gw1.37.28.1 Physcomitrella patens subsp. patens estExt_gwp_gw1.C_1830065 Physcomitrella patens subsp. patens fgenesh1_pg.scaffold_68000055 Physcomitrella patens subsp. patens gw1.211.12.1 Physcomitrella patens subsp. patens 27538.m000318 Ricinus communis 29687.m000571 Ricinus communis 29742.m001433 Ricinus communis 29822.m003360 Ricinus communis 29848.m004476 Ricinus communis 30131.m006865 Ricinus communis 30147.m013975 Ricinus communis 30169.m006518 Ricinus communis estExt_fgenesh1_pg.C_chr_40508 Thalassiosira pseudonana CCMP1335 XP_002959718 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR10217 1.8E-239 35 648 No hit NA SUPERFAMILY SSF81324 6.4E-25 40 227 No hit NA Pfam PF00520 1.6E-9 131 352 IPR005821 Ion transport domain SUPERFAMILY SSF81324 6.4E-25 297 357 No hit NA SUPERFAMILY SSF51206 7.6E-27 365 544 IPR018490 Cyclic nucleotide-binding-like SMART SM00100 1.1E-4 441 560 IPR000595 Cyclic nucleotide-binding domain ProSiteProfiles PS50042 8.5 445 508 IPR000595 Cyclic nucleotide-binding domain Pfam PF00027 2.1E-6 455 532 IPR000595 Cyclic nucleotide-binding domain ProSiteProfiles PS50096 6.6 565 594 IPR000048 IQ motif, EF-hand binding site
Subcellular Localization
Localization	plasma membrane
Evidence	SUBAcon
Pubmed ID	23180787