Basic information
Locus name	AT3G45300
Alias	IVDH
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Protein degradation/modification
Effect for Senescence	delay
Gene Description	encodes isovaleryl-CoA dehydrogenase involved in degradation of the branched-chain amino acids, phytol, and Lys.
Evidence	Genetic evidence:Mutant [Ref 1]
References	1: Ara��jo WL, Ishizaki K, Nunes-Nesi A, Larson TR, Tohge T, Krahnert I, Witt S, Obata T, Schauer N, Graham IA, Leaver CJ, Fernie AR Identification of the 2-hydroxyglutarate and isovaleryl-CoA dehydrogenases as alternative electron donors linking lysine catabolism to the electron transport chain of Arabidopsis mitochondria. Plant Cell 2010 May;22(5):1549-63
Gene Ontology	biological process oxidation-reduction process molecular function acyl-CoA dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors
Sequence	AT3G45300.1 | Genomic | mRNA | CDS | Protein
Mutant information
Mutant name	ivdh-1
Mutant/Transgenic	mutant
Ecotype	Col-0
Mutagenesis type	T-DNA insertion_knock out
miRNA Interaction
Details	target: AT3G45300.1  miRNA: ath-miR774b-5p miRNA: ath-miR774b-5p mfe: -30.6 kcal/mol  p-value: 0.002197  position: 5  target 5' C               U     A  3'             AUUGCUCAUAUCUUC UCUCA                 UAGUGGGUAUAGAAG AGAGU      miRNA  3'                 U        5'
Ortholog Group
Ortholog Groups: OG5_128729	Accession Taxon NP_190116 ( AT3G45300 ) Arabidopsis thaliana CMT072C Cyanidioschyzon merolae strain 10D 128289 Chlamydomonas reinhardtii NP_001054521 Oryza sativa Japonica Group e_gw1.242.78.1 Physcomitrella patens subsp. patens 30111.m000733 Ricinus communis estExt_thaps1_ua_kg.C_chr_100073 Thalassiosira pseudonana CCMP1335 XP_002949842 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR10909 1.3E-232 15 408 No hit NA SUPERFAMILY SSF56645 5.1E-83 28 268 IPR009100 Acyl-CoA dehydrogenase/oxidase PIRSF PIRSF016578 5.1E-8 30 408 No hit NA Pfam PF02771 2.0E-34 33 146 IPR006092 Acyl-CoA dehydrogenase, N-terminal Pfam PF02770 4.6E-19 150 201 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain ProSitePatterns PS00072 NA 152 164 IPR006089 Acyl-CoA dehydrogenase, conserved site SUPERFAMILY SSF47203 3.1E-46 255 408 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal Pfam PF00441 6.0E-46 257 405 IPR006090 Acyl-CoA oxidase/dehydrogenase, type 1 ProSitePatterns PS00073 NA 364 383 IPR006089 Acyl-CoA dehydrogenase, conserved site
Subcellular Localization
Localization 1 Localization mitochondria Evidence Localization with GFP-fusion protein (GFP:cDNA) Pubmed ID 10737809
Localization 2 Localization mitochondrion Evidence SUBAcon Pubmed ID 23180787