Basic information
Locus name	AT1G76490
Alias	HMG1
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Lipid/Carbohydrate metabolism:melavonate biosynthesis
Effect for Senescence	delay
Gene Description	Encodes a 3-hydroxy-3-methylglutaryl coenzyme A reductase, which is involved in melavonate biosynthesis.
Evidence	Genetic evidence:Mutant [Ref 1]
References	1: Suzuki M, Kamide Y, Nagata N, Seki H, Ohyama K, Kato H, Masuda K, Sato S, Kato T, Tabata S, Yoshida S, Muranaka T Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels. Plant J. 2004 Mar;37(5):750-61
Gene Ontology	biological process coenzyme A metabolic process oxidation-reduction process molecular function coenzyme binding hydroxymethylglutaryl-CoA reductase (NADPH) activity
Pathway	KEGG map00900 (EC 1.1.1.34) MetaCyc PWY-922
Sequence	AT1G76490.1 | Genomic | mRNA | CDS | Protein
Mutant information
Mutant name	hmg1-1
Mutant/Transgenic	mutant
Ecotype	Ws
Mutagenesis type	T-DNA insertion_knock out
miRNA Interaction
Details	target: AT1G76490.1  miRNA: ath-miR781 miRNA: ath-miR781 mfe: -28.7 kcal/mol  p-value: 0.005629  position:  1136  target 5' G   A                U 3'             GAG AUCCAGAGAACUUUGA              UUC UAGGUCUUUUGAGAUU   miRNA  3' A   A                  5'  target: AT1G76490.1  miRNA: ath-miR838 miRNA: ath-miR838 mfe: -22.8 kcal/mol  p-value: 0.062697  position:  1709  target 5' G        C            A 3'             GUG GGGA AGUGGGAGGAGG              CAC UUCU UCAUCUUCUUUU   miRNA  3' A   G                   5'
Ortholog Group
Ortholog Groups: OG5_127955	Accession Taxon NP_177775 ( AT1G76490 ) Arabidopsis thaliana NP_179329 Arabidopsis thaliana NP_001062221 Oryza sativa Japonica Group NP_001063541 Oryza sativa Japonica Group estExt_gwp_gw1.C_10125 Physcomitrella patens subsp. patens estExt_gwp_gw1.C_1390001 Physcomitrella patens subsp. patens fgenesh1_pg.scaffold_61000007 Physcomitrella patens subsp. patens 29682.m000571 Ricinus communis 30162.m001288 Ricinus communis 30170.m013805 Ricinus communis e_gw1.4.252.1 Thalassiosira pseudonana CCMP1335
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR10572 0.0 13 640 IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II SUPERFAMILY SSF56542 3.1E-104 219 340 IPR009029 Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding ProSiteProfiles PS50065 140.8 222 626 IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II TIGRFAM TIGR00533 9.1E-161 222 626 IPR004554 Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type Pfam PF00368 8.7E-162 247 626 IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II PRINTS PR00071 4.8E-86 282 303 IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II PRINTS PR00071 4.8E-86 309 329 IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II SUPERFAMILY SSF55035 8.1E-47 343 459 IPR009023 Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding PRINTS PR00071 4.8E-86 400 418 IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II ProSitePatterns PS00066 NA 402 416 IPR023076 Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site PRINTS PR00071 4.8E-86 440 465 IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II SUPERFAMILY SSF56542 3.1E-104 457 615 IPR009029 Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding PRINTS PR00071 4.8E-86 491 517 IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II PRINTS PR00071 4.8E-86 545 566 IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II ProSitePatterns PS00318 NA 557 564 IPR023076 Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site ProSitePatterns PS01192 NA 611 624 IPR023076 Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
Subcellular Localization
Localization 1 Localization ER Evidence Localization with GFP-fusion protein (GFP:cDNA) Pubmed ID 10737809
Localization 2 Localization endoplasmic reticulum Evidence SUBAcon Pubmed ID 23180787